Symptomatic congenital cytomegalovirus infection

Boppana, Suresh B.; Pass, Robert F.; Britt, William J.; Stagno, Sergio; Alford, Charles A.

doi:10.1097/00006454-199202000-00007

Cited by 532 publications

(372 citation statements)

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“…Up to 15% of intrauterine hCMV infections led to congenital symptomatic diseases. Asymptomatic congenital hCMV infection will develop in 10-15% of infants (Boppana et al, 1992;Fowler et al, 1997;Dahle et al, 2000). Intra uterus transmission of hCMV can occur during primary maternal infection, reactivation, or reinfection of seropositive mothers.…”

Section: Introductionmentioning

confidence: 99%

“…Intra uterus transmission of hCMV can occur during primary maternal infection, reactivation, or reinfection of seropositive mothers. Primary hCMV infections are transmitted more frequently to the fetus and are more likely to cause fetal damage than recurrent infections (Stagno et al, 1986;Boppana et al, 1992;Fowler et al, 1992;Fowler et al, 1997;Dahle et al, 2000). If strategies for the prevention of hCMV disease are to be successfully developed, knowledge regarding the epidemiology of the virus is prerequisite.…”

Section: Introductionmentioning

confidence: 99%

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Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Arabpour¹,

Kaviyanee²,

Jankhah³

et al. 2007

MJM

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Human cytomegalovirus (hCMV) has been described as an important etiological agent of intrauterine infection in women of childbearing age that causes congenital malformation. In the present study we examined 844 serum samples from women of child-bearing age for the presence of IgM and IgG antibodies against hCMV by Elisa technique. 764 out of 844 (93%) of the cases were seropositive for hCMV-IgG and 45 (5.4%) cases were seropositive for hCMV-IgM. An increase in the rate of IgG seroprevalance was associated with an increase in age and parity. The IgG seroprevalance rate was inversely proportional to increasing abortions. Intrestingly seasonal variation affected IgG seroprevalance. There was an increasing trend in IgM positivity rate with age in women less than 29 years. hCMV seroprevalence rate was higher in women from rural as compared to those of urban areas. Finally hCMV primary infections occured in 2.4 % of all pregnancis and it is estimated that up to 0.3% of all congenital disorders, through out Fars province, were due to hCMV. We suggest a role of child to mother hCMV transmission and sexual maturity as the most probable epidemiological factors of hCMV seroprevalence among women of child bearing age.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Arabpour¹,

Kaviyanee²,

Jankhah³

et al. 2007

MJM

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“…Outcomes for these infants are poor, and most survivors suffer from severe neurologic sequelae. 4,[33][34][35] The overall mortality rate is ,5%. 10,27,35,36 The majority of children with cCMV are asymptomatic and therefore not diagnosed at birth.…”

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confidence: 99%

“…4,[33][34][35] The overall mortality rate is ,5%. 10,27,35,36 The majority of children with cCMV are asymptomatic and therefore not diagnosed at birth. However, 7% to 15% of clinically asymptomatic patients may develop late sequelae, including SNHL, which is by far the most common sequela.…”

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confidence: 99%

Hearing Loss and Congenital CMV Infection: A Systematic Review

Goderis¹,

Leenheer²,

et al. 2014

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BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children. METHODS:Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes. RESULTS:Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41-0.79). Among these newborns 12.6% (95% confidence interval, 10.2-16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymptomatic children, unilateral loss predominates. In both groups the hearing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies.CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood. Pediatrics 2014;134:972-982

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“…Patients with T cell immunodeficiency particularly fetus, preterm neonates, transplant receivers as well as HIV infected patients are at a higher risk of CMV infection. This virus is the most common factor for congenital and prenatal infections (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

et al. 2016

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Background: Seroprevalence of Cytomegalovirus infection varies between 40% and 100% worldwide. Different studies carried out in Iran indicate this variation in this country. It is important to estimate the total infection prevalence using a reliable method such as meta-analysis in order to be applied by policymakers. This study aims to estimate the IgG and IgM seroprevalences of CMV infection among Iranian women and neonates. Method:We selected eligible articles for final meta-analysis by searching the national and international databases, excluding duplicates and irrelevant papers from primarily identified studies after abstract/full text review, implementing exclusion/inclusion criteria and quality assessment. Standard error of the prevalence was calculated according to binomial distribution formula. Based on the degree of heterogeneity, fixed or random effects models were applied for estimating the pooled prevalences. Results:In this study, 16 papers providing 20 evidences of CMV prevalence in Iran entered in the meta-analysis. CMV IgG and IgM seroprevalences as well as primary infection rate (95% confidence interval) among pregnant women were 92.8% (90.6 -94.9), 6.4% (2.8 -9.9) and 1.1% (0.7 -1.5) respectively. CMV IgM seroprevalence among neonates were 0.6% (0.09 -1.2), while CMV IgG and CMV IgM seroprevalences among non-pregnant women were 78.4% (70 -86.8) and 4.6% (1.5 -7.6) respectively. Conclusions:This meta-analysis showed that the prevalence of CMV infection among studied population is relatively high. Therefore, mortality, complications, anomalies and injuries among fetuses, neonates and immunocompromized patients can be partially related to the CMV infection.

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Symptomatic congenital cytomegalovirus infection

Cited by 532 publications

References 0 publications

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Human cytomegalovirus infection in women of childbearing age throughout Fars Province - Iran: a population-based cohort study

Hearing Loss and Congenital CMV Infection: A Systematic Review

Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

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