Symptomatic and hemopathic hemolytic anemia

Humoral Factors in the Pathogenesis of Chronic Pancytopenias and Their Relation to Hypersplenism

“…Mild hemolytic states seemed to be present in several subjects as evider.ccd by elevated bilirubin values and increased excretion of urobilinogen. Chromium51 survival studies substantiated this impression in those few instances (cases 6-9) in which the test could be performed (21,23). The life span was never extremely short, but the compensatory measures were seemingly inadequate, as there was considerable reticulocytopenia (24) and blood transfusions were often needed to keep the blood values at a satisfactory level.…”

“…One had idiopathic splenomegaly, possibly fungal in origin (case 3). Three could be labelled as refractory anemias with hyperplastic bone marrow (cases 4, 5, 6), or "hemopathic hemolytic anemia", in the more recent terminology (21). One patient had osteomyelosclerosis (case 9), while the remaining two resembled so-called agnogenic myeloid metaplasia (cases 7 and 8) with myeloid infiltrates in spleen and liver (22).…”

Development of Alloanti-Jka in a Patient with Hemolytic Anemia Due to Autoanti-Jkb

“…3 Most autoantibodies associated with autoimmune hemolytic anemia are directed against high-incidence antigens within the Rh system and react with all normal RBCs in addition to autologous RBCs. 4 Antibody speci-…”

A Major Pitfall in the Use of the Same Radioisotope for the Repetition of Erythrocyte and Other Survival Studies

“…Method II should be employed if following an initial deter mination of life span there is exposure to a variety of hemolytic agents (22)(23)(24) or diseases (25) or the development of blood loss. These factors would alter the survival of the originally tagged cells to that of those administered for the followup study.…”