Symptomatic and diagnostic stability in schizophrenia: a one-year follow-up study

Dollfus, Sonia; Petit, Michel; Ménard, J. F.; Lesieur, Philippe

doi:10.1017/s0924933800001917

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…The discrepancy between the (better) predictive value of an initial diagnosis and the (weaker) predictive value of quantitative symptom evaluation emphasizes the fact that the diagnosis process includes much more than evaluation of symptoms themselves. Other variables (e.g., duration of illness, social/occupational dysfunction, prognostic features, exclusion criteria) obviously play a part in the diagnostic process (Dollfus et al 1993).…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Study of Clinical Dimensions in Adolescent-Onset Psychoses

Paillère-Martinot

Aubin

Martinot

et al. 2000

Schizophrenia Bulletin

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Adolescent-onset psychoses often raise diagnostic difficulties because of the mixture of schizophrenic and affective features. This study examined prospectively which clinical dimensions contribute to difficulty in initial diagnosis and which clinical features have predictive value for outcomes of schizophrenia or affective disorders, and for eventual psychosocial functioning. Thirty-six adolescents consecutively admitted for a psychotic episode were followed up for 1 to 4 years. Symptoms were assessed at admission, at discharge, and once a year. DSM-III-R (APA 1989) diagnoses were assessed at admission and once a year. Comparisons were performed across initial and followup diagnostic groups. Positive symptoms did not differentiate the initial clinical pictures, while negative symptoms, manic symptoms, and disorganization differentiated the manic and depressive episodes in the acute phase. When initial positive symptoms (mainly delusions) were severe, they predicted a final diagnosis in the schizophrenia spectrum. Poor outcome was associated with more anhedonia-associality and lower functioning scores at admission. Results suggest (1) a higher vulnerability to positive symptoms in adolescents who will further develop schizophrenia and (2) the low specificity of affective symptoms at this age.

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Section: Discussionmentioning

confidence: 99%

A Prognostic Study of Clinical Dimensions in Adolescent-Onset Psychoses

Paillère-Martinot

Aubin

Martinot

et al. 2000

Schizophrenia Bulletin

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First rank symptoms for schizophrenia

Soares‐Weiser

Maayan

Davenport

et al. 2015

Cochrane Database of Systematic Reviews

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Background Early and accurate diagnosis and treatment of schizophrenia may have long-term advantages for the patient; the longer psychosis goes untreated the more severe the repercussions for relapse and recovery. If the correct diagnosis is not schizophrenia, but another psychotic disorder with some symptoms similar to schizophrenia, appropriate treatment might be delayed, with possible severe repercussions for the person involved and their family. There is widespread uncertainty about the diagnostic accuracy of First Rank Symptoms (FRS); we examined whether they are a useful diagnostic tool to di erentiate schizophrenia from other psychotic disorders. Objectives To determine the diagnostic accuracy of one or multiple FRS for diagnosing schizophrenia, verified by clinical history and examination by a qualified professional (e.g. psychiatrists, nurses, social workers), with or without the use of operational criteria and checklists, in people thought to have non-organic psychotic symptoms.

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Identifying Subtypes of Schizophrenia by Cluster Analyses

Dollfus

Everitt²,

Ribeyre

et al. 1996

Schizophrenia Bulletin

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The existence of two subtypes of schizophrenia (positive and negative) is well established. The evidence in favor of other subtypes, particularly a disorganized subtype, is still the subject of some debate. The aim of the study reported in this article is to investigate the possibility of further subtypes of schizophrenia by applying a particular method of cluster analysis to a particular set of data. Ward's method of cluster analysis was applied to the Positive and Negative syndrome Scale (PANSS) scores of 138 patients, defined as having schizophrenia by one of four diagnostic criteria. The validity of the cluster solution was assessed both by examining differences between clusters on a number of clinical characteristics recorded for each patient and by comparing the results obtained from the PANSS with those derived from a cluster analysis using two other instruments (the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms). Results from the cluster analysis suggest the existence of at least four subtypes of schizophrenia: positive, negative, mixed, and disorganized. A fifth subtype includes patients with few symptoms, suggesting the simple schizophrenia named by Bleuler. Evidence for the validity of these subtypes was provided by the differences observed between the clusters on a number of clinical characteristics and by the similarity of the cluster solution obtained from the different instruments. In conclusion, the negative-positive dichotomy in schizophrenia is an oversimplification, and the existence of a more complex structure needs to be taken into account in future research.

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Symptomatic and diagnostic stability in schizophrenia: a one-year follow-up study

Cited by 4 publications

References 26 publications

A Prognostic Study of Clinical Dimensions in Adolescent-Onset Psychoses

A Prognostic Study of Clinical Dimensions in Adolescent-Onset Psychoses

First rank symptoms for schizophrenia

Identifying Subtypes of Schizophrenia by Cluster Analyses

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