Symptom Patterns of the Occurrence of Depression and Anxiety in a Japanese General Adult Population Sample: A Latent Class Analysis

Lei, Huijie; Chen, Chong; Hagiwara, Kosuke; Kusumi, Ichiro; Tanabe, Hajime; Inoue, Takeshi; Nakagawa, Shin

doi:10.3389/fpsyt.2022.808918

Cited by 10 publications

(16 citation statements)

References 55 publications

(75 reference statements)

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“…So far, by employing LCA, a class of individuals with comorbid depression and anxiety has been consistently identified in samples from the general population at different ages and from different countries. [9][10][11][12][13] In several studies, the comorbidity occurs at multiple levels of symptom severity, for instance, low, moderate and high. 10,11 In some 9,12 but not other 10,11,13 studies, a depression or anxiety class only was also identified.…”

Section: Symptomatologymentioning

confidence: 99%

“…[9][10][11][12][13] In several studies, the comorbidity occurs at multiple levels of symptom severity, for instance, low, moderate and high. 10,11 In some 9,12 but not other 10,11,13 studies, a depression or anxiety class only was also identified. Importantly, these studies have reported unique demographic and psychological characteristics of the comorbid class compared to other classes, for instance, being female, younger age, having fewer years of education, and experiencing more negative life events.…”

Section: Symptomatologymentioning

confidence: 99%

“…8 Given this high comorbidity and shared genetic and psychological risk factors (e.g., early life stress), it has been argued that the 2 disorders may represent a single, common construct of negative affect or psychological distress. 9 Therefore, a full understanding of the underlying mechanism of such comorbidity and the association between and differentiation of the 2 disorders is an urgent issue. In this editorial, an overview of recent studies focused on the symptomatology and neurobiological and neurocomputational mechanisms of the 2 disorders and their comorbidity is provided.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in the study of the comorbidity of depressive and anxiety disorders

Chen¹

2022

Adv Clin Exp Med

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Depressive and anxiety disorders often comorbid, which causes more severe impairments. The high comorbidity and shared genetic and psychological factors between the 2 disorders have brought arguments about whether they represent a common construct, and whether the current classification is meaningful. In this editorial, a state-of-the-art overview of recent studies on the underlying mechanism of such comorbidity, and the association between and differentiation of the 2 disorders is provided. Recent studies employing datadriven approaches such as latent class analysis (LCA) and network analysis to investigate the symptomatology of depression and anxiety have indicated unique characteristics and bridging symptoms of their comorbidity. Whereas previous neurobiological and neuroendocrinological studies reported common alterations in prefrontal-limbic pathways, serotonergic projections and the hypothalamic-pituitary-adrenal (HPA) axis, recent research suggests that distinct neural circuits and heterogeneous changes in HPA activity may exist in depression when compared to anxiety. Lastly, both depression and anxiety have been long associated with decision-making deficits; however, emerging evidence from computational psychiatry demonstrate that there may be unique neurocognitive and computational alterations in each disorder. By investigating the common and unique symptomatic characteristics and underlying neurobiological and neurocomputational mechanisms of the 2 disorders as well as their comorbidity, it can be concluded that recent studies have greatly advanced our understanding of the etiology and neuropathophysiology of these disorders.

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Section: Symptomatologymentioning

confidence: 99%

Section: Symptomatologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent advances in the study of the comorbidity of depressive and anxiety disorders

Chen¹

2022

Adv Clin Exp Med

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“…Using the same sample as the study of Uchida et al, Nakazawa et al 20 similarly reported that the negative evaluation of life events showed a significant direct positive effect on state anxiety. In a recent study, Lei et al found that only subjects in the group with high depression and high anxiety levels had experienced more negative life events in the previous 6 months, or 7 months to 1 year previously than subjects in the healthiest group 27 …”

Section: Introductionmentioning

confidence: 97%

Interpersonal sensitivity mediates the effects of perceived parenting styles on state anxiety and negative assessment of life events in adult volunteers from the community

et al. 2023

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Aim: The association of parenting experiences in childhood with anxiety symptoms in adulthood has yet to be clarified. We hypothesized that interpersonal sensitivity (IPS) mediates the impacts of parenting experiences in childhood on anxiety symptoms and negative assessment of life events in adulthood. Methods: An observational cross-sectional study was carried out from January 2014 to August 2014 on 853 adults. Participants provided their demographic information and answered the following four self-administered questionnaires: Parental Bonding Instrument (PBI), Interpersonal Sensitivity Measure (IPSM), Life Experiences Survey (LES), and State-Trait Anxiety Inventory Form Y (STAI-Y). The data of a total of 404 participants who agreed to take part in this study were analyzed.Results: Multiple regression analysis with the State Anxiety subscale of STAI-Y as the dependent variable identified the following five out of the 15 independent variables as being statistically significant: IPSM total, LES positive and negative, PBI paternal overprotection, and employment status. This model explains 17.8% of the State Anxiety subscale score. In the structural equation models, the Care subscale showed significant indirect negative effects on State Anxiety subscale and LES negative score through a decrease in IPSM total score (β = -0.061 and -0.042, respectively). The former indirect effect accounted for 31.6%, and the latter accounted for 56.8% of the total effects. In contrast, Overprotection subscale had opposite effects to Care subscale. Conclusion:These results suggest that parenting experiences in childhood are related to adult anxiety symptoms and the negative assessment of life events indirectly through IPS.

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“…The categorization standard was too simple to distinguish subgroup characteristics. To resolve this problem and provide more scienti c methods for the classi cation of mental health, recently studies [12,13] have started to apply latent class analysis (LCA) to identify the symptom patterns of depression and anxiety. LCA is a person-centered statistical approach that examines the extent to which symptoms from different pathological conditions co-occur within individuals, and further, whether there are classes of individuals who endorse different symptom pro les [14].…”

Section: Introductionmentioning

confidence: 99%

Latent class analysis of depressive and anxious symptoms among Chinese rheumatoid arthritis patients

Zhang

Zhu

2023

Preprint

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Background: Depression and anxiety create additional burdens for adults with rheumatoid arthritis (RA), negatively affecting disease outcomes and quality of life. Therefore, this study aims to identify symptom patterns of depression and anxiety and explore the influencing factors; In addition, we want to investigate the relationships among different symptom profiles and quality of life in Chinese RA patients. Methods: A total of 355 RA patients (including 293 females, age = 55.05 ± 13.04 years) were recruited in this study. Depression and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale. We applied latent class analysis to identify distinct symptom subgroups of depression and anxiety in RA patients. The latent class subtypes were compared using the One-way ANOVA or chi-square test. Multinomial logistic regression was performed to examine associations between identified classes and related factors. Results: We identified 3 distinct symptom patterns or classes in this study, including the high depressive and anxious symptoms, the moderate depressive and anxious symptoms and the mild anxiety symptoms. The number of RA patients in each class is 131, 72 and 152 respectively. The multinomial logistic regression revealed that compared with the mild anxiety symptoms group, the associated factors of depression and anxiety in other two subgroups were pain and functional capacity. Additionally, we found that different symptom profiles were significantly associated with quality of life in Chinese RA patients. Conclusions: As is known to us, this is the first latent class analysis that categorized the symptom subgroups of depression and anxiety in Chinese RA patients. Our findings suggested that the main factors influencing the high and moderate depressive and anxious symptoms groups are pain and functional capacity and different symptom profiles were significantly associated with quality of life. Rheumatologists and nurses should provide targeted psychological interventions according to different symptom patterns to promote the quality of life among RA patients.

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Symptom Patterns of the Occurrence of Depression and Anxiety in a Japanese General Adult Population Sample: A Latent Class Analysis

Cited by 10 publications

References 55 publications

Recent advances in the study of the comorbidity of depressive and anxiety disorders

Recent advances in the study of the comorbidity of depressive and anxiety disorders

Interpersonal sensitivity mediates the effects of perceived parenting styles on state anxiety and negative assessment of life events in adult volunteers from the community

Latent class analysis of depressive and anxious symptoms among Chinese rheumatoid arthritis patients

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