Symptom experiences of older adults during treatment for metastatic prostate cancer: A qualitative investigation

Parthipan, Milothy; Feng, Gregory; Toledano, Nelly; Donison, Valentina; Breunis, Henriette; Sudharshan, Abirami; Emmenegger, Urban; Finelli, Antonio; Warde, Padraig; Soto‐Pérez‐de‐Celis, Enrique; Krzyzanowska, Monika K.; Matthew, Andrew; Clarke, Hance; Mina, Daniel Santa; Alibhai, Shabbir M.H.; Puts, Martine

doi:10.1016/j.jgo.2022.10.012

Cited by 6 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 Expressions of social support for cancer patients may be in the form of emotional support or tangible support such as helping them with transportation needs or assisting patients in gaining access to information. 20 Among the clinical characteristics explored in this study, only ADT use was found to exert a moderating effect on the relationship between social/family wellbeing and sexual function distress. None of the clinical characteristics was noted to have a moderating effect on the relationship between social/family wellbeing and sexual function.…”

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

“…In conducting the moderated regression analyses, the absence of interaction between the predictor variable and the moderator variable was not assumed or avoided, as it does not imply a causal sequence between the predictor and outcome variables. [17][18][19][20] Threshold α values were 0.05 for all statistical tests. Statistical analyses were performed with SPSS statistics software version 23 (IBM SPSS, Purchase, NY).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer

Rio,

Goto,

Hsiao

et al. 2023

CMAR

View full text Add to dashboard Cite

Purpose Prostate cancer and its treatment may affect patients’ sexual function and social wellbeing. This study investigated the relationship between social/family wellbeing and sexual health in patients with prostate cancer. Additionally, the moderating effect of clinical characteristics on this relationship was also explored. Patients and Methods This is a descriptive correlational study using baseline data of a longitudinal study enrolling 137 patients with prostate cancer. Sexual Function (SF) and Sexual Function Distress (SFD) data were collected using the Symptom Index questionnaire. Demographic data were obtained during study intake and clinical data were obtained from chart review. Bivariate correlation determined the correlations among continuous demographic/clinical data, social/family wellbeing, and sexual health. Moderated regression analysis determined the moderating effects of clinical characteristics on the relationship of social/family wellbeing and sexual health. Results Moderate positive correlation was found between social/family wellbeing and SF, whereas a weak negative correlation was noted between social/family wellbeing and SFD. Depression was significantly correlated with social/family wellbeing and SFD. Both sexual health domains were significantly correlated with Gleason score. A significant difference was noted in the social/family wellbeing and both SF and SFD in participants receiving androgen deprivation therapy (ADT) compared to those not receiving ADT. Concomitant ADT use was the only clinical characteristic found to be a significant moderator of the relationship between social/family wellbeing and SFD, but none of the clinical characteristics was found to have a moderating effect on the relationship of social/family wellbeing and SF. Among patients who were not receiving ADT, high social/family wellbeing was associated with low SFD. Patients who were receiving ADT reported slightly higher SFD despite having higher social/family wellbeing. Conclusion Ensuring sexual health in patients with prostate cancer requires a comprehensive approach to address factors contributing to sexual health such as side effects of treatment and family wellbeing.

show abstract

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer

Rio,

Goto,

Hsiao

et al. 2023

CMAR

View full text Add to dashboard Cite

show abstract

“…While older adults’ interest in self-management has been reported in other studies [ 5 , 43 ], our study highlights the functionalities that support this work. Given that many older adults are managing distressing symptoms as a result of cancer and its treatments, alongside existing chronic illnesses, the impetus to mobilize self-management supports is critical [ 44 ]. Our app in its current state is designed for all older adults with cancer and other illnesses to self-manage their conditions, but it is most useful and valuable for older adults who have just been diagnosed with cancer.…”

Section: Discussionmentioning

confidence: 99%

Tailored Self-Management App to Support Older Adults With Cancer and Multimorbidity: Development and Usability Testing

Sien,

Kobekyaa,

Puts

et al. 2024

JMIR Aging

Self Cite

View full text Add to dashboard Cite

Background Globally, cancer predominates in adults aged older than 60 years, and 70% of older adults have ≥1 chronic condition. Cancer self-management interventions can improve symptom management and confidence, but few interventions target the complex needs of older adults with cancer and multimorbidity. Despite growing evidence of digital health tools in cancer care, there is a paucity of theoretically grounded digital self-management supports for older adults. Many apps for older adults have not been co-designed with older adults to ensure that they are tailored to their specific needs, which would increase usability and uptake. Objective We aim to report on the user evaluations of a self- and symptom-management app to support older adults living with cancer and multimorbidity. Methods This study used Grey’s self-management framework, a design thinking approach, and involved older adults with lived experiences of cancer to design a medium-fidelity app prototype. Older adults with cancer or caregivers were recruited through community organizations or support groups to participate in co-designing or evaluations of the app. Data from interviews were iteratively integrated into the design process and analyzed using descriptive statistics and thematic analyses. Results In total, 15 older adults and 3 caregivers (n=18) participated in this study: 10 participated (8 older adults and 2 caregivers) in the design of the low-fidelity prototype, and 10 evaluated (9 older adults and 1 caregiver) the medium-fidelity prototype (2 older adults participated in both phases). Participants emphasized the importance of tracking functions to make sense of information across physical symptoms and psychosocial aspects; a clear display; and the organization of notes and reminders to communicate with care providers. Participants also emphasized the importance of medication initiation or cessation reminders to mitigate concerns related to polypharmacy. Conclusions This app has the potential to support the complex health care needs of older adults with cancer, creating a “home base” for symptom management and support. The findings from this study will position the researchers to conduct feasibility testing and real-world implementation.

show abstract

“…A meta-analysis of 12 studies comprising 13,524 participants examined the cognitive effects of second-generation anti-androgen therapy (abiraterone, apalutamide, darolutamide, and enzalutamide) in men treated for prostate cancer and found a statistically significant increase in the risk of cognitive toxic effects such as disturbed attention, memory impairment, cognitive disorder, and amnesia with treatment compared to placebo [93]. The effect of ADT on mood is seen in both objective measures and by self-report of patients [94,95]. A clinical trial ongoing at this time will help to determine whether testosterone replacement can improve cognition and mood in prostate cancer survivors deficient in the hormone [96].…”

Section: The Controversymentioning

confidence: 99%

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Reiss,

Gulkarov,

Pinkhasov

et al. 2023

Medicina

View full text Add to dashboard Cite

Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered.

show abstract

Symptom experiences of older adults during treatment for metastatic prostate cancer: A qualitative investigation

Cited by 6 publications

References 9 publications

Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer

Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer

Tailored Self-Management App to Support Older Adults With Cancer and Multimorbidity: Development and Usability Testing

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Contact Info

Product

Resources

About