“…Studies report a high symptom burden and a range of complications among patients with HGG (Armstrong, Cohen, Eriksen, & Hickey, 2004;Ownsworth, Chambers, Hawkes, Walker, & Shum, 2011;Taphoorn & Klein, 2004). Different types of cerebral symptoms and complications may occur, including global cerebral symptoms (fatigue, nausea, headache, confusion), focal symptoms (hemiparesis, seizures, speech difficulties), neurocognitive deficits (impaired attention, concentration difficulties, reduced short-term memory, personality changes), and distressing emotional and psychological reactions (depression, anxiety, stress;Boele, Klein, Reijneveld, Verdonck-de Leeuw, & Heimans, 2014;Kim et al, 2013;Klein et al, 2003;Lovely, Miaskowski, & Dodd, 1999;Molassiotis et al, 2010). Survival and quality of life (QOL) are negatively influenced by this complexity of symptoms and complications.…”