Symptom distress and suicidal ideation among Chinese ovarian cancer patients: A moderated mediation model of depression and suicide resilience

Abstract

ObjectiveThe aim of this study was to examine whether depression mediates the relationship between symptom distress and suicidal ideation in Chinese patients with ovarian cancer, and whether this mediating effect was moderated by suicide resilience.MethodsFrom March to October 2022, this cross-sectional study was performed in a three Grade 3A hospital and an oncology specialty hospital in Wuhan, Hubei Province, China. Ultimately, 213 ovarian cancer patients completed anonymous self-report. Bootstrapping method was used for regression analysis to test the mediating and moderating effects.ResultsAmong the 213 participants, 29.58% (n = 63) exhibited significant suicidal ideation. Symptom distress was positively associated with suicidal ideation, and depression partially mediated this relationship. Suicide resilience moderated the relationship between depression and suicidal ideation. In ovarian cancer patients with low suicide resilience, the effect of symptom distress on suicidal ideation through depression was greater, while in patients with high suicide resilience, this effect was attenuated.ConclusionOur study suggests that symptom distress could be more likely to lead to suicidal ideation as depression levels increase in ovarian cancer patients. Fortunately, suicide resilience could attenuate this negative effect.

Development of a prediction model for suicidal ideation in patients with advanced cancer: A multicenter, real‐world, pan‐cancer study in China

“…Consistent with previous studies, physical symptoms and psychological distress predicted an increased likelihood of SI among patients with advanced cancer. 28 , 29 Previous research suggested that quality of life could act as a mediator in the association between symptom burden and SI, 4 and thus active symptom control, for example, analgesia, to improve the overall life quality should be essential to reduce SI. From the nomogram, anxiety and depression contributed the most to the model, which underlined the important role of anxiety/depression in the formation of SI.…”