Symptom clusters in patients with nasopharyngeal carcinoma during radiotherapy

Xiao, Wei; Chan, Carmen W.H.; Fan, Yun; Leung, Doris Y. P.; Xia, Wei‐Xiong; He, Yan; Tang, Lin‐Quan

doi:10.1016/j.ejon.2017.02.004

Cited by 33 publications

(69 citation statements)

References 41 publications

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“…Seven studies (63.6%) assessed patients with heterogeneous HN topographies [Murphy et al, 2010;Xiao et al, 2013;Rosenthal et al, 2014;Kirca and Kutlutürkan, 2017;Barnhart et al, 2018;Chiang et al, 2018;Ridner et al, 2018], 2 studies (18.2%) assessed patients with oropharyngeal/laryngeal tumors [Haisfield-Wolfe et al, 2012;Eraj et al, 2017], and 2 studies (18.2%) assessed patients with nasopharyngeal tumors [Xiao et al, 2017;McDowell et al, 2018]. Eight studies (72.2%) reported specific information on patients' stage of disease, from which 6 (54.5%) assessed patients in clinical stage I-IV [Haisfield-Wolfe et al, 2012;Rosenthal et al, 2014;Eraj et al, 2017;Kirca and Kutlutürkan, 2017;Xiao et al, 2017;McDowell et al, 2018] and 2 (18.2%) assessed patients with advanced disease (clinical stage III/IV) [Xiao et al, 2013;Chiang et al, 2018].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Information on treatment modalities were also retrieved from the included studies: 7 studies (63.6%) assessed patients treated with either RT or CRT protocols [Haisfield-Wolfe et al, 2012;Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;Barnhart et al, 2018;Mc-Dowell et al, 2018;Ridner et al, 2018], 2 studies (18.2%) assessed patients submitted to RT [Kirca and Kutlutürkan, 2017;Chiang et al, 2018], and 2 studies (18.2%) assessed patients submitted to CRT protocols [Murphy et al, 2010;Xiao et al, 2013]. Four studies (36.3%) reported the use of the intensity-modulated RT technique for radiation delivery [Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;McDowell et al, 2018], 1 study (7.1%) reported the use of intensity-modulated RT and 3D conformational RT [Barnhart et al, 2018], and 1 study (7.1%) compared the outcomes of the accelerated and standard fractionation RT [Xiao et al, 2013]. For the studies that assessed CRT protocols as treatment modality, cisplatin was the main medication used [Haisfield-Wolfe et al, 2012;Xiao et al, 2013;Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;McDowell et al, 2018].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Four studies (36.3%) reported the use of the intensity-modulated RT technique for radiation delivery [Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;McDowell et al, 2018], 1 study (7.1%) reported the use of intensity-modulated RT and 3D conformational RT [Barnhart et al, 2018], and 1 study (7.1%) compared the outcomes of the accelerated and standard fractionation RT [Xiao et al, 2013]. For the studies that assessed CRT protocols as treatment modality, cisplatin was the main medication used [Haisfield-Wolfe et al, 2012;Xiao et al, 2013;Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;McDowell et al, 2018].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Considering the treatment-related toxicity assessment, 5 studies (45.4%) assessed patients both during RT and after RT completion [Murphy et al, 2010;Haisfield-Wolfe et al, 2012;Xiao et al, 2013;Kirca and Kutlutürkan, 2017;Barnhart et al, 2018], 3 studies (27.3%) assessed patients after the conclusion of RT [Eraj et al, 2017;McDowell et al, 2018;Ridner et al, 2018], and 3 studies (27.3%) assessed patients during the course of RT [Rosenthal et al, 2014;Xiao et al, 2017;Chiang et al, 2018]. For the classification of the observed toxicities, 5 studies (45.4%) used the MD Anderson Symptom Inventory [Rosenthal et al, 2014;Eraj et al, 2017;Xiao et al, 2017;Chiang et al, 2018;McDowell et al, 2018], 2 studies (28.2%) used The Memorial Symptom Assessment Scale [Haisfield-Wolfe et al, 2012;Kirca and Kutlutürkan, 2017], 1 (9.1%) used the NCI Common Toxicity Criteria 2.0 [Xiao et al, 2013], 1 (9.1%) used the Vanderbilt Head and Neck Symptom Survey [Murphy et al, 2010], 1 (9.1%) used the Vanderbilt Head and Neck Symptom Survey version 2.0 [Ridner et al, 2018], and 1 (7.1%) characterized the toxicities as present or absent [Barnhart et al, 2018].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Results of the risk of bias assessment are shown in Figure 2. Six studies (54.5%) were classified as moderate risk of bias [Murphy et al, 2010;Haisfield-Wolfe et al, 2012;Rosenthal et al, 2014;Kirca and Kutlutürkan, 2017;Barnhart et al, 2018;Ridner et al, 2018], and 5 studies (45.4%) were classified as low risk of bias [Xiao et al, 2013;Eraj et al, 2017;Xiao et al, 2017;Chiang et al, 2018;McDowell et al, 2018].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

See 4 more Smart Citations

Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review

et al. 2020

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review

et al. 2020

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A network analysis of self‐reported psychoneurological symptoms in patients with head and neck cancer undergoing intensity‐modulated radiotherapy

Lin

Bruner

Paul

et al. 2022

Cancer

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Background Patients with head and neck cancer experience psychoneurological symptoms (PNS) (i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity‐modulated radiotherapy (IMRT) that decrease their functional status, quality of life, and survival rates. The purpose of this study was to examine and visualize the relationships among PNS within networks over time and evaluate for demographic and clinical characteristics associated with symptom networks. Methods A total of 172 patients (mean age, 59.8 ± 9.9 years; 73.8%, male; 79.4%, White) completed symptom questionnaires four times, namely, before IMRT (T1), 1 month (T2), 3 months (T3), and 12 months (T4) post IMRT. Network analysis was used to examine the symptom‐symptom relationships among PNS. Centrality indices, including strength, closeness, and betweenness, were used to describe the degrees of symptom network interconnections. Network comparison test was used to assess the differences between two symptom networks. Results Depression was associated with the other four symptoms, and fatigue was associated with the other three symptoms across the four assessments. Based on the centrality indices, depression (rstrength = 1.3–1.4, rcloseness = 0.06–0.08, rbetweeness = 4–10) was the core symptom in all symptom networks, followed by fatigue. Female gender, higher levels of stress, and no alcohol use were associated with stronger symptom networks in network global strength before IMRT. Conclusion Network analysis provides a novel approach to gain insights into the relationships among self‐reported PNS and identify the core symptoms and associated characteristics. Clinicians may use this information to develop symptom management interventions that target core symptoms and interconnections within a network. Lay summary This study describes the symptom–symptom relationships for five common symptoms in patients with head and neck cancer receiving radiotherapy. Depression and fatigue appeared to be two core symptoms that were connected with sleep disturbance, pain, and cognitive dysfunction within a network. Several characteristics (i.e., female, higher stress, no alcohol use) were associated with stronger symptom networks.

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Predictive effect of pretreatment nutritional risk and GLIM‐defined malnutrition on the nutrition impact symptom clusters in patients with head and neck cancer undergoing radiotherapy

Wang

Zhang

et al. 2022

Head & Neck

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Background Evidence supporting predictive effects of pretreatment nutritional risk and nutritional status on nutrition impact symptom (NIS) clusters during radiotherapy in patients with head and neck cancer (HNC) is insufficient. Methods At baseline (T1), we collected severity and interference of NIS (Head and Neck Patient Symptom Checklist), nutritional risk, and nutritional status. During (T2) and at the end of radiotherapy (T3), we re‐evaluated NIS. Symptom clusters were identified by exploratory factor analysis using mean scores of NIS severity at T2 and T3. Predictive effects were explored by generalized estimating equations. Results Five hundred thirty‐seven patients were recruited and 334 of them completed. Four clusters were identified; the oropharyngeal symptom cluster was the most severe and had the greatest interference with diet. Patients with pretreatment nutritional risk or malnutrition experienced more severe oropharyngeal symptom cluster. Conclusions Pretreatment nutritional risk or malnutrition could predict the oropharyngeal symptom cluster in patients with HNC undergoing radiotherapy.

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Symptom clusters in patients with nasopharyngeal carcinoma during radiotherapy

Cited by 33 publications

References 41 publications

Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review

Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review

A network analysis of self‐reported psychoneurological symptoms in patients with head and neck cancer undergoing intensity‐modulated radiotherapy

Predictive effect of pretreatment nutritional risk and GLIM‐defined malnutrition on the nutrition impact symptom clusters in patients with head and neck cancer undergoing radiotherapy

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