Symptom Clusters in Men and Women With Heart Failure and Their Impact on Cardiac Event-Free Survival

Lee, Kyoung Suk; Song, Eun Kyeung; Lennie, Terry A.; Frazier, Susan K.; Chung, Misook L.; Heo, Seongkum; Wu, Jia Rong; Rayens, Mary Kay; Riegel, Bárbara; Moser, Debra K.

doi:10.1097/jcn.0b013e3181cfbb88

Cited by 78 publications

(149 citation statements)

References 54 publications

(41 reference statements)

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“…This claim is supported by significant relationships among the variables studied (symptoms), with correlation coefficients ranging from r = -0.3 (fatigue and sleep disturbance) to 0.8 (anxiety and depression) at p \ 0.05, warranting further investigation. In symptom cluster studies involving moderate to advanced HF patients, investigators found that anxiety (worrying) and depression are clustered within emotional/cognitive symptoms whereas fatigue and sleep disturbance clustered as physical symptoms [20,21]. Thus, our results support the need for more symptom-cluster research in HF and mechanical circulatory support.…”

Section: Discussionsupporting

confidence: 83%

A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device

Casida

Parker

2011

J Artif Organs

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Despite increased use of left ventricular assist devices (LVAD) in patients with advanced or end-stage heart failure; little is known about the reoccurrence of common heart failure symptoms (e.g., fatigue) after LVAD implantation. The objective of this study was to investigate the prevalence and pattern of selected heart failure symptoms and identify changes in symptom patterns before and up to 6 months after LVAD implantation. We used self-report questionnaires to collect data from patients (n = 12) and measure symptoms at baseline, 1 and 2 weeks, and 1, 3, and 6 months after LVAD. We found that high levels of fatigue, anxiety, depression, and sleep disturbance were prevalent during these periods. However, we did not find any significant changes in symptom pattern over time. The preliminary findings set the starting point for large-scale studies fundamental to advances in symptom-management research in LVAD and for other patients living with artificial organs.

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Section: Discussionsupporting

confidence: 83%

A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device

Casida

Parker

2011

J Artif Organs

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“…With patient or family assistance, hospital discharge and other medical records were obtained from identified sources of care outside of the study‐site healthcare systems. We have >20 years of experience collecting these data and have successfully obtained hospitalization data on all rural patients in our current and previous studies 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41. All‐cause mortality data (date and cause of death) were collected for 1 year from baseline by a combination of medical record review, electronic clinical record review, interviews with patients’ healthcare providers and family, and public death record review 30, 31, 40, 41, 42, 43…”

Section: Methodsmentioning

confidence: 99%

Micronutrient Deficiency Independently Predicts Time to Event in Patients With Heart Failure

Lennie

Andreae

Rayens

et al. 2018

JAHA

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BackgroundDietary micronutrient deficiencies have been shown to predict event‐free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart failure was associated with shorter event‐free survival, defined as a combined end point of all‐cause hospitalization and death.Methods and ResultsFour‐day food diaries were collected from 246 patients with heart failure (age: 61.5±12 years; 67% male; 73% white; 45% New York Heart Association [NYHA] class III/IV) and analyzed using Nutrition Data Systems for Research. Micronutrient deficiencies were determined according to methods recommended by the Institute of Medicine. Patients were followed for 1 year to collect data on all‐cause hospitalization or death. Patients were divided according to number of dietary micronutrient deficiencies at a cut point of ≥7 for the high deficiency category versus <7 for the no to moderate deficiency category. In the full sample, 29.8% of patients experienced hospitalization or death during the year, including 44.3% in the high‐deficiency group and 25.1% in the no/moderate group. The difference in survival distribution was significant (log rank, P=0.0065). In a Cox regression, micronutrient deficiency category predicted time to event with depression, NYHA classification, comorbidity burden, body mass index, calorie and sodium intake, and prescribed angiotensin‐converting enzyme inhibitors, diuretics, or β‐blockers included as covariates.ConclusionsThis study provides additional convincing evidence that diet quality of patients with heart failure plays an important role in heart failure outcomes.

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“…Studies have suggested that the occurrence of multiple symptoms frequently leads to the occurrence of symptom clusters 51 . These symptom clusters might be more important to explore rather than individual symptoms, especially when it comes to determining the impact on outcomes 52,53 .…”

Section: Limitationsmentioning

confidence: 99%

Symptom burden in stable COPD patients with moderate or severe airflow limitation

et al. 2014

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Running head: Symptom burden in moderate or severe airflow limitations Symptom burden in stable COPD patients with moderate or severe airflow limitations. AbstractObjectives. To describe a multidimensional symptom profile in patients with stable chronic obstructive pulmonary disease (COPD) and determine whether symptom experience differed between patients with moderate or severe airflow limitations.Background. Patients with severe airflow limitation experience numerous symptoms, but

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Symptom Clusters in Men and Women With Heart Failure and Their Impact on Cardiac Event-Free Survival

Cited by 78 publications

References 54 publications

A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device

A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device

Micronutrient Deficiency Independently Predicts Time to Event in Patients With Heart Failure

Symptom burden in stable COPD patients with moderate or severe airflow limitation

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