Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Wong‐Chew, Rosa María; Cabrera, Edwin Xchel Rodríguez; Valdez, Carlos Alberto Rodríguez; Lomelín-Gascón, Julieta; Morales-Juárez, Linda; Cerda, Mariana Lizbeth Rodríguez de la; Villa-Romero, Antonio Rafael; Fernández, Stephanie Arce; Fernandez, Mariana Serratos; Bello, Héctor Herrera; Castañeda, Lidia Moreno; Avendaño, Mónica; Hernández-Cruz, Jesús Abraham; Martínez, Nelson Álvarez; Contreras, Liza Fernanda; Cerda, Luis Rafael González de la; Flores, A.; Martínez-Juárez, Luis Alberto; Álvarez-Hernández, Diego-Abelardo; Gallardo-Rincón, Héctor; Dolci, Germán Fajardo; Tapia‐Conyer, Roberto; Valdez-Vázquez, Rafael

doi:10.1177/20499361211069264

Cited by 32 publications

(34 citation statements)

References 35 publications

(50 reference statements)

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“…Regarding sex, it was evidenced that women presented more post-acute symptoms (feeling of anxiety, brittle hair, difficulty concentrating, headache, insomnia, nausea, neuritis, hair loss, memory defects, muscle loss, dry skin, easy crying, and brittle nails) when compared to men, findings similar to those presented by Sudre et al and Whitaker et al in self-report studies in the population of the United Kingdom [32,33], Mexico [34] and Spain [25]. While these differences may be because women are more likely to participate in this type of investigations and are more aware of their health, only one study has shown that men are more likely to develop long-covid than women [26,35].…”

Section: Discussionsupporting

confidence: 78%

“…The effect of the severity of the infection (antecedent) characterized by the treatment that the participants claimed to receive showed that in contrast to responders who did not develop sequelae, having presented severe infection pictures (hospitalization for more than 7 days and / or hospitalization in the intensive care unit) was a great risk condition (OR = 7.79; 2.34 -25.88) for the development of post-acute sequelae of COVID-19 when compared with mild infection (outpatient treatment and non-treatment).Similar effects have been evidenced in various studies characterized by the use of mechanical ventilation, and having been hospitalized [27,31,33,34].…”

Section: Discussionsupporting

confidence: 69%

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Long COVID at Low and High Altitude: A Countrywide Epidemiological Analysis of Self-Reported Long-Term Persisting Symptoms in Ecuador

Izquierdo-Condoy¹,

Fernández-Naranjo²,

Vásconez³

et al. 2022

Preprint

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Background: Some patients who have recovered from COVID-19 have experienced a range of persistent symptoms or the appearance of new ones after a SARS-CoV-2 infection. These symptoms can last from weeks to months, impacting everyday functioning to a significant number of patients. Methods: A cross-sectional analysis based on an online, self-reporting questionnaire was conducted in Ecuador from April to July 2022. Participants were invited by social media, radio, and TV to voluntarily participate in our study. A total of 2103 surveys were included in this study. We compared socio-demographic variables and long-term persisting symptoms at low (&lt; 2,500 m) and high altitude (&gt;2,500 m).Results: Overall, 1100 (52.3%) responders claimed to have long-term symptoms after SARS-CoV-2 infection. Most of these symptoms were reported by women (64.0%), the most affected group was young adults (68.5%), and the majority of long-haulers were mestizos (91.6%). We found that high altitude residents were more likely to report persisting symptoms (71.7%) versus those living at lower altitudes (29.3%). The most common symptoms were fatigue or tiredness (8.4%), hair loss (5.1%) and difficulty concentrating (5.0%). The highest proportion of persisting symptoms was observed among those who received an incomplete vaccine scheme.Conclusions: This is the first study describing post-COVID symptoms' persistence in low and high-altitude residents. Our findings demonstrate that women, especially those aging between 20-40, are more likely to describe sequalae associated with post-COVID. We also found that living at a high altitude was associated with earlier onset and longer symptom duration. Finally, we found a greater risk to report long lasting symptoms among women, those with previous comorbidities and those who had a severer acute SARS-CoV-2 infection.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 69%

Long COVID at Low and High Altitude: A Countrywide Epidemiological Analysis of Self-Reported Long-Term Persisting Symptoms in Ecuador

Izquierdo-Condoy¹,

Fernández-Naranjo²,

Vásconez³

et al. 2022

Preprint

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“…Second, some sequelae had a small sample size so that the pooled estimate may not be generalized. Third, clinical symptoms may have various diagnostic standards and symptoms such as cough and chest pain were mainly self-reported [ 20 , 25 , 29 – 31 , 36 , 38 , 40 – 43 , 46 , 47 , 51 – 58 , 60 , 62 , 74 , 80 , 81 , 86 , 88 , 89 , 91 ], as healthcare resources were already stretched coping with the evolving pandemic. Finally, the excess burden of each sequela compared to the general population was not quantified which were available from a limited number of controlled cohort studies only.…”

Section: Discussionmentioning

confidence: 99%

Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis

Yang

Yan

et al. 2022

Infection

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Objective Although complications and clinical symptoms of COVID-19 have been elucidated, the prevalence of long-term sequelae of COVID-19 is less clear in previously hospitalized COVID-19 patients. This review and meta-analysis present the occurrence of different symptoms up to 1 year of follow-up for previously hospitalized patients. Methods We performed a systematic review from PubMed and Web of Science using keywords such as “COVID-19”, “SARS-CoV-2”, “sequelae”, “long-term effect” and included studies with at least 3-month of follow-up. Meta-analyses using random-effects models were performed to estimate the pooled prevalence for different sequelae. Subgroup analyses were conducted by different follow-up time, regions, age and ICU admission. Results 72 articles were included in the meta-analyses after screening 11,620 articles, identifying a total of 167 sequelae related to COVID-19 from 88,769 patients. Commonly reported sequelae included fatigue (27.5%, 95% CI 22.4–33.3%, range 1.5–84.9%), somnipathy (20.1%, 95% CI 14.7–26.9%, range 1.2–64.8%), anxiety (18.0%, 95% CI 13.8–23.1%, range 0.6–47.8%), dyspnea (15.5%, 95% CI 11.3–20.9%, range 0.8–58.4%), PTSD (14.6%, 95% CI 11.3–18.7%, range 1.2–32.0%), hypomnesia (13.4%, 95% CI 8.4–20.7%, range 0.6–53.8%), arthralgia (12.9%, 95% CI 8.4–19.2%, range 0.0–47.8%), depression (12.7%, 95% CI 9.3–17.2%, range 0.6–37.5%), alopecia (11.2%, 95% CI 6.9–17.6%, range 0.0–47.0%) over 3–13.2 months of follow-up. The prevalence of most symptoms reduced after > 9 months of follow-up, but fatigue and somnipathy persisted in 26.2% and 15.1%, respectively, of the patients over a year. COVID-19 patients from Asia reported a lower prevalence than those from other regions. Conclusions This review identified a wide spectrum of COVID-19 sequelae in previously hospitalized COVID-19 patients, with some symptoms persisting up to 1 year. Management and rehabilitation strategies targeting these symptoms may improve quality of life of recovered patients. Supplementary Information The online version contains supplementary material available at 10.1007/s15010-022-01862-3.

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“…Involvement of both the central and peripheral nervous systems was common within the first 14 days of the SARS-CoV-2 infection [ 7 ]. Moreover, a substantial number of patients experienced persistent neurological symptoms within 90 days after discharge from the COVID-19 ward [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

et al. 2022

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We aimed to search whether neurological symptoms or signs (NSS) and the MEWS (Modified Early Warning Score) score were associated with in-hospital mortality or oxygen requirement during the first 14 days of hospitalization in COVID-19 patients recruited at the University Hospital in Krakow, Poland. The detailed clinical questionnaires on twenty NSS were either filled out by patients prospectively or retrospectively assessed by neurologists based on daily medical records. NSS were considered high or low-risk if they were associated with increased or decreased mortality in the univariable analysis. This cohort study included 349 patients with COVID-19 (median age 64, interquartile range (51–77), women 54.72%). The presence of high-risk NSS (decreased level of consciousness, delirium, seizures, and symptoms of stroke or transient ischemic attack) or its combination with the absence of low-risk NSS (headache, dizziness, decreased mood, and fatigue) increased the risk of in-hospital mortality in SARS-CoV-2 infection 3.13 and 7.67-fold, respectively. The presence of low-risk NSS decreased the risk of in-hospital mortality in COVID-19 patients more than 6-fold. Death in patients with SARS-CoV-2 infection, apart from NSS, was predicted by older age, neoplasm, and higher MEWS scores on admission. High-risk NSS or their combination with the absence of low-risk NSS increased the risk of oxygen requirement during hospitalization in COVID-19 patients 4.48 and 1.86-fold, respectively. Independent predictors of oxygen therapy during hospitalization in patients with SARS-CoV-2 infection were also older age, male sex, neoplasm, and higher MEWS score on admission.

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Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City

Cited by 32 publications

References 35 publications

Long COVID at Low and High Altitude: A Countrywide Epidemiological Analysis of Self-Reported Long-Term Persisting Symptoms in Ecuador

Long COVID at Low and High Altitude: A Countrywide Epidemiological Analysis of Self-Reported Long-Term Persisting Symptoms in Ecuador

Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis

Neurological Prognostic Factors in Hospitalized Patients with COVID-19

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