Symplocosins C–P: Fourteen Triterpene Saponins from the Leaves of <i>Symplocos cochinchinensis</i> var. <i>philippinensis</i>

Abstract

Extensive phytochemical work on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Symplocos cochinchinensis var. philippinensis resulted in the isolation of 14 new triterpenene saponins, along with four known ones. Their structures were elucidated by comparison of NMR spectroscopic data with related compounds reported in the literature. Three oleanane-type saponins, symplocosins K, M, and P, possessed glucuronic acid as a sugar component, and their carboxyl groups appeared as methyl esters. These are probably formed during extraction and isolation procedures. Symplocosin K (9) showed moderate cytotoxicity toward A549 cells. In addition, all isolated compounds did not show α-glucosidase inhibitory activity.

Component Analysis and Anti-Colorectal Cancer Mechanism via AKT/mTOR Signalling Pathway of Sanghuangporus vaninii Extracts

“…In the 60% ethanol extract of S. vaninii, 43 compounds were obtained, including 35 compounds tentatively identified by comparison of absorption spectra with the online database ChemSpider, and reported values in the literature together with the remaining 8 were not identified by either absorption or mass spectra [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Table 1). The results showed that phenolics were the essential component of SVE60, including phenolic acids, flavonoids and phenylpropanoids (Figures 1 and 2).…”