Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats

Antu, Kalathookunnel Antony; Riya, Mariam Philip; Mishra, Arvind; Sharma, Sharad; Srivastava, Arvind K.; Raghu, Kozhiparambil Gopalan

doi:10.1016/j.etp.2014.05.004

Cited by 7 publications

(9 citation statements)

References 43 publications

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“…4A & B, P≤0.05). This result is in line with the reported protective effect of SCE on hepatic oxidative stress markers in STZ diabetic animal model [41]. It has been suggested that during hyperglycemic conditions, a non-enzymatic reaction occur between proteins and monosacharides (glycation) leading to the formation of pathologically significant AGEs [42].…”

Section: Discussionsupporting

confidence: 88%

“…This pancreatic beta cell proliferation potential of test material represent an extremely useful criteria to evaluate anti-diabetic activity, which could protect the beta cells from degeneration due to gluco-lipotoxicity during type 2 diabetes mellitus or protect from autoimmune mediated destruction as in the case of type 1 diabetes mellitus [47]. We had seen the protective property of SCE against streptozotocin induced toxicity in pancreas [41]. With this result, we strongly believe that this beneficial property contribute significantly to its antidiabetic efficiency.…”

Section: Discussionmentioning

confidence: 97%

“…From the SEM microstructure analysis of AGEs, it is clear that SCE, SCEC and SCEL exhibited antiglycation via its AGE inhibitor property [44]. The in vitro method had shown potent metal chelation capacity of SC which may be the mechanism behind the better antiglycation potential of this plant and the reported diminished %HbA1c level in the SCE treated STZ diabetic animal model [41].…”

Section: Discussionmentioning

confidence: 99%

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Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity

et al. 2014

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The study is designed to find out the biochemical basis of antidiabetic property of Symplocos cochinchinensis (SC), the main ingredient of ‘Nisakathakadi’ an Ayurvedic decoction for diabetes. Since diabetes is a multifactorial disease, ethanolic extract of the bark (SCE) and its fractions (hexane, dichloromethane, ethyl acetate and 90% ethanol) were evaluated by in vitro methods against multiple targets relevant to diabetes such as the alpha glucosidase inhibition, glucose uptake, adipogenic potential, oxidative stress, pancreatic beta cell proliferation, inhibition of protein glycation, protein tyrosine phosphatase-1B (PTP-1B) and dipeptidyl peptidase-IV (DPP-IV). Among the extracts, SCE exhibited comparatively better activity like alpha glucosidase inhibition (IC50 value-82.07±2.10 µg/mL), insulin dependent glucose uptake (3 fold increase) in L6 myotubes, pancreatic beta cell regeneration in RIN-m5F (3.5 fold increase) and reduced triglyceride accumulation (22% decrease) in 3T3L1 cells, protection from hyperglycemia induced generation of reactive oxygen species in HepG2 cells (59.57% decrease) with moderate antiglycation and PTP-1B inhibition. Chemical characterization by HPLC revealed the superiority of SCE over other extracts due to presence and quantity of bioactives (beta-sitosterol, phloretin 2′glucoside, oleanolic acid) in addition to minerals like magnesium, calcium, potassium, sodium, zinc and manganese. So SCE has been subjected to oral sucrose tolerance test to evaluate its antihyperglycemic property in mild diabetic and diabetic animal models. SCE showed significant antihyperglycemic activity in in vivo diabetic models. We conclude that SC mediates the antidiabetic activity mainly via alpha glucosidase inhibition, improved insulin sensitivity, with moderate antiglycation and antioxidant activity.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity

et al. 2014

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“…From ancient times, diabetic patients have used medicinal plants to maintain blood glucose level [ 30 ]. In this regard, the present study is extended to show the influence of A. maurorum extracts on blood glucose level, oxidative stress, and lipid profile in STZ-induced diabetic rats [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin‐Induced Diabetes Mellitus in Rats: Role of Alhagi maurorum Extracts

Sheweita

Mashaly

Newairy

et al. 2016

Oxidative Medicine and Cellular Longevity

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Alhagi maurorum (camel thorn plant) is a promising medicinal plant due to the presence of flavonoids and phenolic compounds as major contents of its constituents. No previous study has been conducted before on A. maurorum extracts as an antioxidative stress and/or antidiabetic herb in STZ-induced DM in rats. Therefore, four groups of rats were allocated as control (C), STZ-induced DM (D), and STZ-induced DM supplemented with 300 mg/kg BW of either aqueous extract (WE) or ethanolic extract (EE) of A. maurorum. The plasma levels of glucose, TG, TC, LDL-C and VLDL-C, MDA, and bilirubin and the activities of transaminases and GR were significantly increased in the diabetic group. Also, diabetic rats showed severe glucose intolerance and histopathological changes in their livers. In addition, levels of insulin, total proteins, GSH, and HDL-C and the activities of SOD, GPx, and GST were significantly decreased in the diabetic rats compared to those of the control group. The ingestion of A. maurorum extracts lowered the blood glucose levels during the OGTT compared to the diabetic rats and restored all tested parameters to their normal levels with the exception of insulin level that could not be restored. It is concluded that A. maurorum extracts decreased elevated blood glucose levels and hyperlipidemia and suppressed oxidative stress caused by diabetes mellitus in rats.

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“…Improved tolerance to Glucose PLE may be due to direct inhibition of glucose uptake in the small intestine. [47] Allium sativum Garlic stimulates insulin secretion. Effect is by restoration of insulin and inhibition of absorption from intestines and glucose creation.…”

Section: Cinnamonmentioning

confidence: 99%

The most useful medicinal herbs to treat diabetes

et al. 2018

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Diabetes mellitus is a syndrome that is characterized by hyperglycemia, change in the metabolism of lipids, carbohydrates, and proteins, and in the long term, with eye, kidney, cardiovascular, and neurological complications. Plenty of plants from different regions of the world have been investigated for anti-diabetic effects. This review article was designed to report some of the most important medicinal plants with hypoglycemic properties according to reliable clinical and laboratory evidence, and also touched on the medicinal plants that are prescribed in Iranian traditional medicine, for the treatment of diabetes. The information in this review was obtained from the eligible articles retrieved using the search terms diabetes mellitus, medicinal plants, type 1 diabetes and medicinal plants, type 2 diabetes and medicinal plants, and the effect of extract and essential oil of medicinal plants affecting diabetized tissues in the human body indexed in databases such as Iran medex, Irandoc, ISI, PubMed, Scopus, SID, Magiran, Google Scholar, etc. Based on the results drawn in this review the plants, Urtica, Trigonella foenum-graecum, Allium sativum, Carthamus tinctorius, Ferula assa-foetida, Bauhinia, Gymnema sylvestre, Swertia, Combretum, Sarcopoterium, Liriope, Caesalpinia bonduc, Coccinia grandis, Syzygium cumini, Mangifera indica, Momordica charantia, Ocimum tenuiflorum, Pterocarpus, Tinospora cordifoli, Salvia officinalis, Panax, Cinnamomum verum, Abelmoschus moschatus, Vachellia nilotica, Achyranthes, Fabaceae, Mentha, Asphodelaceae, Andrographis paniculata L, Artemisia herba-alba, Artemisia dracunculus, Azadirachta indica, Caesalpinioideae, Pachira aquatic, Gongronema latifolium, Nigella Sativa, Tinospora cordifolia (guduchi), Chrysanthemum morifolium, Zingiber zerumbet, Symphytum, Cactaceae, Symplocos, Perilla frutescens, Terminalia chebula and Aloe vera are effective to controland treat diabetes.

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Symplocos cochinchinensis attenuates streptozotocin-diabetes induced pathophysiological alterations of liver, kidney, pancreas and eye lens in rats

Cited by 7 publications

References 43 publications

Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity

Antidiabetic Property of Symplocos cochinchinensis Is Mediated by Inhibition of Alpha Glucosidase and Enhanced Insulin Sensitivity

Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin‐Induced Diabetes Mellitus in Rats: Role of Alhagi maurorum Extracts

The most useful medicinal herbs to treat diabetes

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