Sympathischer Gefäßtonus bei β-Blockade

Schömig, Albert; Dietz, Rainer; Kaden, F; Lüth, J. B.; Mäurer, W

doi:10.1007/978-3-642-72336-0_29

Cited by 3 publications

(3 citation statements)

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“…1) atenolol, a °'cardioselective" ill-receptor antagonist, and also bunitrolol and methypranol did not significantly affect vascular fia-receptors at these concentrations and, therefore, had no effect on flow resistance. The increase of resistance due to fiz-adrenergic blockade by propranolol and pindolol may be of clinical interest, because enhanced flow resistance is also demonstrable after long-term treatment with propranolol ( [9], unpublished results). Moreover, different haemodynamic effects of chronic non-selective//-blockade and chronic /jl-selective blockade in patients with hypertension following adrenaline infusion had been shown recently [4].…”

Section: Discussionmentioning

confidence: 93%

Effects of?-adrenergic blocking agents on peripheral vascular resistance

Rascher

Mann

Schömig³

et al. 1978

Klin Wochenschr

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The effects of the beta-adrenergic blocking agents propranolol, pindolol, atenolol, bunitrolol, and methypranol on the vascular resistance of isolated perfused hindlimbs of rats were investigated. At concentrations of 0.01 microgram/ml in the perfusate dl-propranolol and pindolol significantly increased vascular resistance by blockade of beta2-receptor mediated vasodilatation, whereas atenolol, bunitrolol and methypranol had no effect on peripheral resistance at this concentration. With increasing concentrations up to 10 microgram/ml all drugs, with the exception of atenolol, caused vasodilatation. We conclude that the specificity of beta-blocking agents can be established in the isolated perfused hindlimb vasculature of rats through its effect on vascular resistance. The lack of inhibition of vascular beta2-receptors at low concentrations of atenolol and also bunitrolol and methypranol show relative selectivity for beta1-receptors. The differential effects of beta-adrenergic agents on vascular resistance may have significance for the clinical use of the drugs.

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Section: Discussionmentioning

confidence: 93%

Effects of?-adrenergic blocking agents on peripheral vascular resistance

Rascher

Mann

Schömig³

et al. 1978

Klin Wochenschr

Self Cite

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show abstract

“…Systemic administration of dexamethasone to rats led to an increase in catecholamine vasoconstriction in isolated perfused mesenteric artery [58] and increased pressor responsiveness to noradrenaline [59,GO]. Vasoconstriction has also been observed after local application of glucocorticoids to vessels in rabbit ear [ G l ] and rat hind limb [62].…”

Section: Corticosteroid Excessmentioning

confidence: 99%

“…At high dosc in vitro, corticosteroids inhibited both extraneuronal reabsorption of noradrenaline [72] and catechol-0-methyltransferase metabolism [37,381. However, in a number of studies in vivo these effects could not be shown to be relevant [48,62,68,73].…”

Section: Effects On Vascular Smooth Muscle Cellsmentioning

confidence: 99%