2024
DOI: 10.1161/hypertensionaha.123.21715
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Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation

Murray D. Esler,
John W. Osborn,
Markus P. Schlaich

Abstract: The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20 th century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and… Show more

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