Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation
Murray D. Esler,
John W. Osborn,
Markus P. Schlaich
Abstract:The importance of the sympathetic nervous system in essential hypertension has been recognized in 2 eras. The first was in early decades of the 20
th
century, through to the 1960s. Here, the sympathetic nervous system was identified as a target for the treatment of hypertension, and an extensive range of antiadrenergic therapies were developed. Then, after a period of lapsed interest, in a second era from 1985 on, the development of precise measures of human sympathetic nerve firing and… Show more
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