Sympathetic Overactivity in Patients with Rheumatic Mitral Stenosis

Özdemir, Özcan; Alyan, Ömer; Soylu, Mustafa; Metin, Fatma; Demir, Ahmet Duran; Geyık, Bilal; Aras, Dursun; Özbakır, Cemal; Cihan, Gökhan; Şaşmaz, Hatice; Korkmaz, Şule

doi:10.1111/j.1542-474x.2004.94575.x

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…It was observed in this study that the cumulative symptom-free rate would increase by 2.1% if there was a 1-bpm acceleration in the maximum upright heart rate in standing-up test. However, body mass index, mean corpuscular hemoglobin concentration, 24 h urinary sodium excretion and platelet, reported to have correlations with blood volume or autonomic nervous function (9, 10, 12, 28), were not independent indicators for the long-term outcomes for their un-representativeness of both blood volume and autonomic nervous function. Additionally, allergic diseases, common comorbidities in pediatric POTS patients (29, 30), and inheritance were not testified as independent factors.…”

Section: Discussionmentioning

confidence: 89%

Long-Term Outcomes of Children and Adolescents With Postural Tachycardia Syndrome After Conventional Treatment

Tao

Lin

et al. 2019

Front. Pediatr.

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Objectives: To explore the long-term outcomes of children and adolescents with postural tachycardia syndrome receiving conventional interventions. Materials and Methods: A total of 121 patients were recruited, but 6 (5.0%) of them were lost at follow-up. The detailed clinical data were collected, and the reoccurrence and frequency of orthostatic intolerance symptoms were evaluated with a mean followed-up period of 18.7 months (range, 14–74 months). The Kaplan-Meier curve was used to show the cumulative symptom-free rate of patients over time. Factors influencing the long-term outcomes were examined using the Cox's proportional hazards models. Results: The cumulative symptom-free rate was gradually increased over time. It was 48.4% at the 1-year follow-up and increased to 85.6% at the 6-year follow-up. The duration of symptoms before treatment and the maximum upright heart rate in standing-up test were identified as independent indicators for the long-term outcomes. Each 1-month prolongation in the duration of symptoms before treatment was associated with a 1.2% decrease in the cumulative symptom-free rate. However, each 1-bpm increase in the maximum upright heart rate in standing-up test was associated with a 2.1% increase in the cumulative symptom-free rate. Conclusions: The long-term outcomes of postural tachycardia syndrome patients who received conventional interventions are benign and the cumulative symptom-free rate was gradually increased over time. The prolonged duration of symptoms before treatment and the reduced maximum upright heart rate in standing-up test are the independent risk indicators.

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Section: Discussionmentioning

confidence: 89%

Long-Term Outcomes of Children and Adolescents With Postural Tachycardia Syndrome After Conventional Treatment

Tao

Lin

et al. 2019

Front. Pediatr.

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“…We previously demonstrated that the increase in LF/HF and decrease in SDNN in patients with mitral stenosis are correlated with left atrial dimensions and left ventricular ejection fraction. 34 However, the decrease in LF/HF and increase in SDNN after percutaneous mitral balloon commissurotomy were correlated with the changes in atrial pressures rather than the changes in ejection fraction. 35 Similarly, in this study we found that the mean HR, SDNN, LF day were correlated with right atrial pressure, RAD, and the changes in LF, LF/HF, and SDNN after PBV are correlated mostly with the changes in the atrial pressures.…”

Section: Discussionmentioning

confidence: 90%

Sympathetic Overactivity in Patients with Pulmonary Stenosis and Improvement after Percutaneous Balloon Valvuloplasty

Alyan¹,

Özdemir²,

Kacmaz³

et al. 2008

Noninvasive Electrocardiol

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“…Unlike patients with coronary artery disease, depending on the type of valvular disease pathophsiological mechanisms are different in patients with valvular disease. Even though the studies on valvular diseases are not numerous, especially studies about surgical corrections of valvular diseases and the impact of that on HRV, Ozdemir et al in their two reports [19,20] on patients with mitral stenosis pointed out the existence of significant autonomic disbalance and assumed increased sympathetic activity in those patients. It is also even more significant that after percutaneous balloon commissurotomy in those patients [19] pressure in the atria becomes decreased and that leads to improvement of HRV variables and to lowering of the autonomic disbalance.…”

Section: Discussionmentioning

confidence: 99%

Heart rate variability in patients after cardiac valve surgery

Lakušić¹,

Slivnjak²,

Baborski³

et al. 2008

Open Medicine

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AbstractThe aim of study was to analyze heart rate variability (HRV) after different cardiac valve surgery procedures and the prognostic values of these findings. This study included 101 consecutive patients who underwent surgical implantation for an artificial valve. The mean age of the patients was 62 ± 10 years. An aortic valve was implanted in 65 patients. A mitral valve was implanted in 36 patients. HRV was analyzed from 24 hours Holter electrocardiographic (ECG) records. The time from the operation to the recording of Holter ECG and measuring HRV was 3.8 ± 1.4 months. After discharged from stationary cardiac rehabilitation, all involved patients were contacted to provide data on their health in the follow-up period (33 ± 21 months). A total of 46 patients with an implanted artificial valve had decreased overall HRV or standard deviation of all normal R-R intervals (SDNN) < 93 ms. Patients with an implanted artificial mitral valve had a shorter RR interval (817 ± 122 vs. 863 ± 122ms, p=0.03) and lower values of total power (1166 ± 1888 vs. 2802 ± 3601 ms2, p<0.001) compared to patients with an implanted artificial aortic valve. The results of study show that several months after cardiac surgery, almost half of the patients with an implanted artificial valve have decreased HRV. However, postoperative decreased HRV in those patients have no importance in long-term prediction of mortality rate.

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Sympathetic Overactivity in Patients with Rheumatic Mitral Stenosis

Abstract: As a result, sympathetic nervous system activity is increased in patients with mitral stenosis and sympathetic overactivity worsens their symptoms. Most significant factors that affect autonomic functions in these patients are left atrial dilatation and mitral valve area.

Cited by 8 publications

References 26 publications

Long-Term Outcomes of Children and Adolescents With Postural Tachycardia Syndrome After Conventional Treatment

Long-Term Outcomes of Children and Adolescents With Postural Tachycardia Syndrome After Conventional Treatment

Sympathetic Overactivity in Patients with Pulmonary Stenosis and Improvement after Percutaneous Balloon Valvuloplasty

Heart rate variability in patients after cardiac valve surgery

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