Sympathetic ophthalmia: to the twenty-first century and beyond

Chu, Xi; Chan, Chi‐Chao

doi:10.1186/1869-5760-3-49

Cited by 98 publications

(126 citation statements)

References 62 publications

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“…Sympathetic cochleolabyrinthitis represents a explanation considering the time of onset, 80% between the first two weeks and three months and 10% in the following year in the sympathetic ophthalmia [11], the loss of all frequencies, the association with vertigo and the good response of one of our patient to corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

“…The surgical injury could result in a release of sequestered antigens to the systemic circulation, which would be capable of damaging to the contralateral ear, what has been named in ophthalmology as sympathetic ophthalmia, in which an immunologic response following eye trauma or surgery injuries the contralateral eye [10,11]. This has been studied in animal models in which sensitized lymphocytes were able to transfer autoimmune inner disease, resulting in cellular infiltration by neutrophil granulocytes and lymphocytes in the scala tympani, loss of outer hair cells in the apical turn and loss of detection of TEOAE in the studied animals [12].…”

Section: Discussionmentioning

confidence: 99%

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Contralateral Sensorineural Hearing Loss (SNHL) after Vestibular Schwannoma Surgery: Report of 4 cases

Rivas¹

2017

JOENTR

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We performed a review of the VS operated in our institution between 2004 and 2015, finding a total of 185 cases. Four of these patients developed a contralateral SNHL after VS surgery (Table 1). They were 3 men and 1 woman, with an average tumour size of 19,5 mm (range 7,8-30mm). Three of them were operated by a retrosigmoid approach, and the other one by a translabyrinthine approach. At the time of diagnosis of the VS, 2 patients had normal hearing (pure tone average (PTA): 20 and 22 dB) and 2 has mild hearing loss (PTA: 26 and 40 dB). After surgery all patients developed a complete hearing loss in the operated ear. The median time of appearance of the contralateral SNHL was 16 months (range 2-54 months) with an average of hearing loss in the contralateral ear at the moment of diagnosis of 46dB. Moreover, 3 patients developed tinnitus in the contralateral ear and 2 of them developed also episodic vertigo. AbstractContralateral sensorineural hearing loss after vestibular schwannoma (VS) resection has been described, resulting in a severe complication, especially if hearing preservation in the operated side was not a reachable outcome. There exist several theories that would explain this complication, without any guideline of treatment established. We report four patients treated in our institution who developed a severe contralateral SNHL after surgery. After medical treatment only one patient recovered hearing (moderate SNHL) and the other 3 presented a severe SNHL. Cochlear implant was the only treatment of choice in two of them.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contralateral Sensorineural Hearing Loss (SNHL) after Vestibular Schwannoma Surgery: Report of 4 cases

Rivas¹

2017

JOENTR

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“…The fellow non-traumatized sympathizing eye also shows similar inflammatory response usually with mutton-fat KPs suggesting involvement of autoimmune response [1]. Though the time from ocular injury to onset of SO was said to vary greatly, ranging from a few days to fifty years with 90% of the cases occurring within 1 year [2][3][4][5], recent series showed that only one-third of patients developed SO within 3 months and fewer than 50% did so within 1 year of injury [6].…”

Section: Introductionmentioning

confidence: 94%

Sympathetic Ophthalmia

Demissie¹

2014

AOVS

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BackgroundSympathetic ophthalmia (SO) is a rare bilateral, diffuse granulomatous panuveitis that occurs following penetrating trauma or intraocular surgery to one eye, the exciting eye. The fellow non-traumatized sympathizing eye also shows similar inflammatory response usually with mutton-fat KPs suggesting involvement of autoimmune response [1]. Though the time from ocular injury to onset of SO was said to vary greatly, ranging from a few days to fifty years with 90% of the cases occurring within 1 year [2][3][4][5], recent series showed that only one-third of patients developed SO within 3 months and fewer than 50% did so within 1 year of injury [6].It has been speculated that an infectious agent or a bacterial antigen may precipitate an immune response resulting in the development of SO; but instigating organisms were not identified and the precise etiology of SO remains unknown to this time [5,7].The prevalence of SO is difficult to measure because it has always been a relatively rare disease plus as a result of improvements in modern surgical and medical treatments, it has now become even more uncommon. It accounted for about 0.3% of uveitis and its 1-year incidence was calculated to be a minimum of 0.03/100,000 population [8]. In a retrospective analysis of 2,340 cases of open-globe injuries in Iran, 0.08% (only two cases) was diagnosed with sympathetic ophthalmia from 1998 to 2003 [9].Patients with SO typically present with asymmetric bilateral panuveitis with more severe inflammation in the exciting eye than in the sympathizing eye at least initially. Signs and symptoms in the sympathizing eye vary in their severity and onset ranging from mild problem in near vision, photophobia and slight redness to very severe granulomatous anterior uveitis [5].Significant improvements in the management of ocular trauma combined with the advent of immune-modulators (including corticosteroids) and the use of antibiotics has led to a dramatic decrease in the incidence of sympathetic ophthalmia. However intraocular surgery is now considered the major risk factor particularly vitreoretinal surgery [10,11]. Case PresentationA 24-year-old male patient from Southwest Ethiopia presented to Jimma hospital eye department in March 2009 with pain and loss of right eye (OD) vision following trauma from a flying stone four months back. He was also having severe left eye (OS) pain associated with progressive reduction of vision, photophobia, redness and headache since three months. On examination, vision was no light perception (NLP) in OD and hand motion in OS. Intraocular pressure (IOP) was hypotonous in OD and 22mmHg in OS. The right eye was having hyperemic conjunctiva, irregular raised scleral scar nasally, hazy cornea, diffuse large KPs, shallow anterior chamber (A/C), irregular nonreactive pupil and contracted eyeball. In the left eye he was having ciliary flush, hazy cornea with endothelial dusting and many large KPs, A/C was deep, turbid aqueous with 4+ cells, sluggishly reactive pupil and limited lens and posterior segment...

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“…In our patient, the injury had occurred to the right eye nearly 20 years ago. SO is a serious public health problem as it can lead to blindness in both eyes [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

A case of Vogt-Koyanagi-Harada disease mimicking sympathetic ophthalmia

2015

J Coast Life Med

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Sympathetic ophthalmia: to the twenty-first century and beyond

Cited by 98 publications

References 62 publications

Contralateral Sensorineural Hearing Loss (SNHL) after Vestibular Schwannoma Surgery: Report of 4 cases

Contralateral Sensorineural Hearing Loss (SNHL) after Vestibular Schwannoma Surgery: Report of 4 cases

Sympathetic Ophthalmia

A case of Vogt-Koyanagi-Harada disease mimicking sympathetic ophthalmia

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