Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val158Met polymorphism in patients with panic disorder

Kang, Eun-Ho; Song, Yoon‐Jae; Kim, Kyung-Jeong; Shim, Hyun-Bo; Park, Joo-Eon; Yu, Bum-Hee

doi:10.1016/j.jad.2009.10.008

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…The L/L genotype of the COMT genetic polymorphism is associated with panic disorder. Panic disorder patients with this genotype display a poorer treatment response, compared with those with other genotypes (Woo et al, 2002;Kang et al, 2010).…”

Section: Discussionmentioning

confidence: 87%

Plasma catecholamine levels before and after paroxetine treatment in patients with panic disorder

Heo

et al. 2015

Psychiatry Research

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Section: Discussionmentioning

confidence: 87%

Plasma catecholamine levels before and after paroxetine treatment in patients with panic disorder

Heo

et al. 2015

Psychiatry Research

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“…The Spielberger's State Anxiety Inventory (STAI-S) was administered to all subjects. Skin temperature was used to determine sympathetic nervous function and was measured using a previously established method 17. Skin temperature reflects cutaneous circulation, which is controlled by the sympathetic vasoconstrictor and vasodilator nerves.…”

Section: Methodsmentioning

confidence: 99%

Temperament Affects Sympathetic Nervous Function in a Normal Population

Kim

Lee

Kang

et al. 2012

Psychiatry Investig

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ObjectiveAlthough specific temperaments have been known to be related to autonomic nervous function in some psychiatric disorders, there are few studies that have examined the relationship between temperaments and autonomic nervous function in a normal population. In this study, we examined the effect of temperament on the sympathetic nervous function in a normal population.MethodsSixty eight healthy subjects participated in the present study. Temperament was assessed using the Korean version of the Cloninger Temperament and Character Inventory (TCI). Autonomic nervous function was determined by measuring skin temperature in a resting state, which was recorded for 5 minutes from the palmar surface of the left 5th digit using a thermistor secured with a Velcro® band. Pearson's correlation analysis and multiple linear regression were used to examine the relationship between temperament and skin temperature.ResultsA higher harm avoidance score was correlated with a lower skin temperature (i.e. an increased sympathetic tone; r=-0.343, p=0.004) whereas a higher persistence score was correlated with a higher skin temperature (r=0.433, p=0.001). Hierarchical linear regression analysis revealed that harm avoidance was able to predict the variance of skin temperature independently, with a variance of 7.1% after controlling for sex, blood pressure and state anxiety and persistence was the factor predicting the variance of skin temperature with a variance of 5.0%.ConclusionThese results suggest that high harm avoidance is related to an increased sympathetic nervous function whereas high persistence is related to decreased sympathetic nervous function in a normal population.

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Behavioral Genetics of Affective and Anxiety Disorders

Domschke

Reif

2011

Current Topics in Behavioral Neurosciences

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As shown by clinical genetic studies, affective and anxiety disorders are complex genetic disorders with genetic and environmental factors interactively determining their respective pathomechanism. Advances in molecular genetic techniques including linkage studies, association studies, and genome-wide association studies allow for the detailed dissection of the genetic influence on the development of these disorders. Besides the molecular genetic investigation of categorical entities according to standardized diagnostic criteria, intermediate phenotypes comprising neurobiological or neuropsychological traits (e.g., neuronal correlates of emotional processing) that are linked to the disease of interest and that are heritable, have been proposed to be closer to the underlying genotype than the overall disease phenotype. These intermediate phenotypes are dimensional and more precisely defined than the categorical disease phenotype, and therefore have attracted much interest in the genetic investigation of affective and anxiety disorders. Given the complex genetic nature of affective and anxiety disorders with an interaction of multiple risk genes and environmental influences, the interplay of genetic factors with environmental factors is investigated by means of gene-environment interaction (GxE) studies. Pharmacogenetic studies aid in the dissection of the genetically influenced heterogeneity of psychotropic drug response and may contribute to the development of a more individualized treatment of affective and anxiety disorders. Finally, there is some evidence for genetic factors potentially shared between affective and anxiety disorders pointing to a possible overlapping phenotype between anxiety disorders and depression.

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Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val158Met polymorphism in patients with panic disorder

Cited by 10 publications

References 23 publications

Plasma catecholamine levels before and after paroxetine treatment in patients with panic disorder

Plasma catecholamine levels before and after paroxetine treatment in patients with panic disorder

Temperament Affects Sympathetic Nervous Function in a Normal Population

Behavioral Genetics of Affective and Anxiety Disorders

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