Sympathetic-leptin relationship in obesity: effect of weight loss

Quilliot, Didier; Böhme, Philip; Zannad, Faı̈ez; Ziegler, O.

doi:10.1016/j.metabol.2007.11.020

Cited by 38 publications

(29 citation statements)

References 28 publications

(31 reference statements)

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“…Additional support can be found in the observation that changes in heart rate and muscle sympathetic nerve stimulation after the infusion of antihypertensive and antihypotensive drugs were found to be significantly smaller in the obese than the non-obese (Grassi et al, 1995). Further, obesity is associated with a state of leptin resistance in humans, and hyperleptinaemia is related to lower sympathetic nervous system activity in obese individuals (Quilliot et al, 2008), whereas circulating leptin has been shown to relate to acute stressinduced increases in heart rate in non-obese humans (Brydon et al, 2008). Thus, it is possible that obese individuals become resistant to the sympatho-activating effects of leptin, resulting in blunted reactivity.…”

Section: Body Mass Index Obesity and Cardiovascular Reactivitymentioning

confidence: 82%

Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health

Phillips

2011

Biological Psychology

115

103

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The reactivity hypothesis implicates exaggerated cardiovascular reactions to acute psychological stress in the development of hypertension and other cardiovascular disease outcomes. However, cardiovascular reactivity has also been suggested as a mediator between a variety of psychosocial and behavioural risk factors and cardiovascular disease. Data from various analyses of the West of Scotland Twenty-07 study are discussed together, and caution against over-stretching the original reactivity hypothesis. Blood pressure and heart rate were assessed at rest and during an acute mental arithmetic stress task. First, depression, though a putative risk factor for cardiovascular disease, does not appear to confer this risk via exaggerated reactivity, as it was negatively related to reactivity.Second, obesity, another risk factor, was also associated with blunted rather than heightened reactivity.Finally, lower reactivity was related to poorer self-reported health. Similar associations emerged from both cross-sectional and prospective analyses. These seemingly paradoxical results are discussed in terms of implications for the reactivity hypothesis.

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Section: Body Mass Index Obesity and Cardiovascular Reactivitymentioning

confidence: 82%

Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health

Phillips

2011

Biological Psychology

115

103

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“…[70] Respective changes in parasympathetic and sympathetic activities were assessed by analyzing time domain HR variability, QT dynamicity, and spectral components on ambulatory electrocardiographs after a 6-month diet plus sibutramine (10 or 20 mg/day) weight loss programme. [71] At 6 months, low frequencies (LF, mainly related to the sympathetic nervous system) significantly decreased, whereas high frequencies (HF) were higher than the initial value.…”

Section: Autonomic Nervous Systemmentioning

confidence: 88%

Cardiovascular Risk-Benefit Profile of Sibutramine

Scheen

2010

American Journal Cardiovascular Drugs

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SUMMARYSibutramine is a combined norepinephrine and serotonin reuptake inhibitor used as an antiobesity agent to reduce appetite and promote weight loss in combination with diet and exercise. At a daily dose of 10-20 mg, it was initially considered to have a good safety profile as it does not induce primary pulmonary hypertension or adverse effects on cardiac valves, in contrast to what was previously reported with some other anti-obesity agents. However, it exerts

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“…Many human studies showed that the sympathetic nervous system activity is critical in augmentation of diet-induced obesity (Davy and Orr, 2009), and that the brain regulates energy intake, simultaneously modulating energy expenditure through the sympathetic nervous system (Berthoud, 2008). In human beings, Quilliot et al found that obese subjects with high leptin levels have a lower sympathetic activity than obese subjects with low leptin levels (Quilliot et al, 2008). Interestingly, this inverse relationship between the leptin and sympathetic activity persists at the end of a weight loss program, suggesting that reduced sympathetic responsiveness to endogenous leptin production might be a pathophysiological feature of obesity (Quilliot et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…In human beings, Quilliot et al found that obese subjects with high leptin levels have a lower sympathetic activity than obese subjects with low leptin levels (Quilliot et al, 2008). Interestingly, this inverse relationship between the leptin and sympathetic activity persists at the end of a weight loss program, suggesting that reduced sympathetic responsiveness to endogenous leptin production might be a pathophysiological feature of obesity (Quilliot et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Body mass index is related to autonomic nervous system activity as measured by heart rate variability

et al. 2009

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Autonomic nervous system activity is involved in body weight regulation. We assessed whether the body mass index (BMI) is related to the autonomic nervous system activity as assessed by heart rate variability (HRV). Twenty-five adult normotensive, euglycemic healthy males (M) and females (F) were studied (M/F ¼ 13/12). BMI was assessed in each individual. HRV was assessed and the domains of low frequencies (LF, index of the sympathetic modulation) and high frequencies (HF, index of the parasympathetic modulation) were measured. Data were statistically analyzed and are presented as mean±s.d. Mean BMI did not correlate with either HF or LF. It inversely related to HF (r ¼ À0.50, Po0.01), whereas its relationship with LF was marginally significant (r ¼ À0.39, P ¼ 0.05). The HF in individuals with BMI o20 kg/m 2 was significantly higher from those measured in the remaining subjects (Po0.05). The results support the role of parasympathetic activity in influencing BMI through likely modulation of body weight.

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Sympathetic-leptin relationship in obesity: effect of weight loss

Cited by 38 publications

References 28 publications

Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health

Blunted cardiovascular reactivity relates to depression, obesity, and self-reported health

Cardiovascular Risk-Benefit Profile of Sibutramine

Body mass index is related to autonomic nervous system activity as measured by heart rate variability

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