Sympathetic innervation of interscapular brown adipose tissue is not required for hindbrain administration of oxytocin to stimulate brown adipose tissue (BAT) thermogenesis and reduce weight gain and adiposity in DIO rats
Abstract:Previous studies indicate that CNS administration of oxytocin (OT) reduces body weight in high fat diet‐induced obese (DIO) rodents by reducing food intake and increasing energy expenditure (EE). We recently demonstrated that hindbrain [fourth ventricular (4V)] administration of OT elicits weight loss and elevates interscapular brown adipose tissue temperature (TIBAT; surrogate marker of increased EE) in DIO rats. What remains unclear is whether OT‐elicited weight loss requires increased sympathetic nervous sy… Show more
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