Sympathetic cooling of trapped negative ions by self-cooled electrons in a fourier transform ion cyclotron resonance mass spectrometer

Li, Guozhong; Guan, Shenheng; Marshall, Alan G.

doi:10.1016/s1044-0305(97)84131-1

Cited by 18 publications

(11 citation statements)

References 36 publications

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“…In addition, pulsing collision gas into the ICR trap significantly decreases the duty cycle (spectrum acquisition rate) of the FTICR instrument if high performance is to be maintained. Other ion cooling approaches include ion evaporative [55], adiabatic [36,38], resistive [56] and sympathetic [57] cooling. Though these approaches have been shown to provide effective cooling for particular applications, they have not been widely adopted because of a decrease in signal intensity (e.g., evaporative cooling), reduced capability of ion cooling over a broad m/z range (e.g., adiabatic cooling), inefficiency at higher cyclotron frequencies where detection is mostly capacitive (e.g., resistive cooling) or extended cooling time for hot heavier ions to be cooled by electrons (e.g., sympathetic cooling).…”

Section: Direct Infusion Experimentsmentioning

confidence: 99%

An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics

Belov

Anderson

Wingerd

et al. 2004

J. Am. Soc. Mass Spectrom.

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We describe a fully automated high performance liquid chromatography 9.4 tesla Fourier transform ion resonance cyclotron (FTICR) mass spectrometer system designed for proteomics research. A synergistic suite of ion introduction and manipulation technologies were developed and integrated as a high-performance front-end to a commercial Bruker Daltonics FTICR instrument. The developments incorporated included a dual-ESI-emitter ion source; a dualchannel electrodynamic ion funnel; tandem quadrupoles for collisional cooling and focusing, ion selection, and ion accumulation, and served to significantly improve the sensitivity, dynamic range, and mass measurement accuracy of the mass spectrometer. In addition, a novel technique for accumulating ions in the ICR cell was developed that improved both resolution and mass measurement accuracy. A new calibration methodology is also described where calibrant ions are introduced and controlled via a separate channel of the dual-channel ion funnel, allowing calibrant species to be introduced to sample spectra on a real-time basis, if needed. We also report on overall instrument automation developments that facilitate high-throughput and unattended operation. These included an automated version of the previously reported very high resolution, high pressure reversed phase gradient capillary liquid chromatography (LC) system as the separations component. A commercial autosampler was integrated to facilitate 24 h/day operation. Unattended operation of the instrument revealed exceptional overall performance: Reproducibility (1-5% deviation in uncorrected elution times), repeatability (Ͻ20% deviation in detected abundances for more abundant peptides from the same aliquot analyzed a few weeks apart), and robustness (high-throughput operation for 5 months without significant downtime). When combined with modulated-ionenergy gated trapping, the dynamic calibration of FTICR mass spectra provided decreased mass measurement errors for peptide identifications in conjunction with high resolution capillary LC separations over a dynamic range of peptide peak intensities for each spectrum of 10 3 , and Ͼ10 5 for peptide abundances in the overall separation. (J Am Soc Mass Spectrom 2004, 15, 212-232)

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Section: Direct Infusion Experimentsmentioning

confidence: 99%

An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics

Belov

Anderson

Wingerd

et al. 2004

J. Am. Soc. Mass Spectrom.

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“…However, cooling molecular ions and clusters, both translationally and internally, still remains a formidable challenge. 8 Very often "cooling ions" in the mass spectrometry community really means collisional damping and reducing ion temperatures down to or below room temperature. 9 While this is satisfactory in most cases in mass spectrometry applications, it is far less ideal for spectroscopy studies and ion molecule reactions.…”

mentioning

confidence: 99%

Vibrational cooling in a cold ion trap: Vibrationally resolved photoelectron spectroscopy of cold C60− anions

Wang

Woo²,

Wang³

2005

The Journal of Chemical Physics

139

192

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We demonstrate vibrational cooling of anions via collisions with a background gas in an ion trap attached to a cryogenically controlled cold head (10-400 K). Photoelectron spectra of vibrationally cold C60(-) anions, produced by electrospray ionization and cooled in the cold ion trap, have been obtained. Relative to spectra taken at room temperature, vibrational hot bands are completely eliminated, yielding well-resolved vibrational structures and a more accurate electron affinity for neutral C60. The electron affinity of C60 is measured to be 2.683+/-0.008 eV. The cold spectra reveal complicated vibrational structures for the transition to the C60 ground state due to the Jahn-Teller effect in the ground state of C60(-). Vibrational excitations in the two A(g) modes and eight H(g) modes are observed, providing ideal data to assess the vibronic couplings in C60(-).

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“…In MALDI time-of-flight mass spectrometry, electrons will escape from the ablation plume quickly due to the presence of strong electric fields for ion acceleration. However, if a field-free method is employed, such as in the delayed extraction time-of-flight experiments, or in ion trapping techniques such as Fourier transform ion cyclotron resonance (FT-ICR) 3 mass spectrometry, these electrons may affect the signal intensities, for example, through the mechanism of sympathetic cooling. 4 Recently, we have shown that the electrons originating from the MALDI source can be successfully used to enhance the signals from negative ions in FT-ICR experiments.…”

mentioning

confidence: 99%

Letter: Characteristics of Photoelectrons Emitted in Matrix-Assisted Laser Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Experiments

Gorshkov

Frankevich

Zenobi

2002

Eur J Mass Spectrom (Chichester)

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We show a simple method to study the characteristics of electrons emitted from the metal target in matrix-assisted laser desorption/ionization (MALDI) experiments. The method is based on measurements of SF 6 ion appearance curves by introducing SF 6 as a buffer gas into the vacuum chamber during laser desorption. We obtained the energy distribution of emitted electrons, as well as information on their origin and on ion formation mechanisms in MALDI experiments.

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Sympathetic cooling of trapped negative ions by self-cooled electrons in a fourier transform ion cyclotron resonance mass spectrometer

Cited by 18 publications

References 36 publications

An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics

An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics

Vibrational cooling in a cold ion trap: Vibrationally resolved photoelectron spectroscopy of cold C60− anions

Letter: Characteristics of Photoelectrons Emitted in Matrix-Assisted Laser Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Experiments

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