Symmetrische bullöse akrale Erytheme bei einer 58-jährigen alkoholabhängigen Frau

Chichakli, H.; Frosch, Peter J.; Brinkmeier, Thomas

doi:10.1007/s00105-006-1128-5

Cited by 2 publications

(2 citation statements)

References 7 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pellagra is a chronic disease affecting integumentary, CNS and GIT due to deficiency of niacin/Tryptophan 4 . Its multifactorial, however the commonest cause is alcoholism 5 . Alcoholic liver disease which is present in half of alcohol dependent population also contributes to cutaneous findings 6 .…”

Section: Discussionmentioning

confidence: 99%

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

Shaz,

Shilpa,

Mohan

2023

JCBS

View full text Add to dashboard Cite

Alcoholism a chronic condition affects multiple organ systems including skin. Dermatological markers of alcohol abuse are invaluable. Despite this, association of skin diseases and alcohol misuse maybe overlooked or physicians fail to explore. Pellagra is a multifactorial disease caused by Niacin/Tryptophan deficiency. It exhibits photodermatitis, gastrointestinal and neuropsychiatric manifestations. Chronic alcoholics are at risk. Considering pellagra as differential diagnosis in chronic alcoholics with these symptoms is crucial. This disease is easily treatable but if missed proves fatal. Hence, its recognition is important in other clinical settings for comprehensive treatment. The pathognomonic presentation of Pellagra is the Casal necklace, but here we present a case of 34year old alcoholic with an atypical presentation of Pellagra. Chronic alcoholics need evaluation for Pellagra amongst other nutritional deficiencies which due to diverse presentation can be missed. Early diagnosis and treatment can avoid impending neuropsychiatric complications. Due to participation of numerous disciplines consultation liaison psychiatry is vital here. Keywords: Alcohol dependence, Alcohol cutaneous manifestations, Pellagra, Niacin deficiency, Alcohol biomarkers

show abstract

Section: Discussionmentioning

confidence: 99%

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

Shaz,

Shilpa,

Mohan

2023

JCBS

View full text Add to dashboard Cite

show abstract

“…Chilblains have been observed in rare monogenic type 1 interferonopathies, in which an antiviral innate immune response is excessively activated [133]. Nevertheless, such vigorous innate immune response can cause transient NAD + depletion, manifesting in acral skin lesions characteristic for pellagra [134]. Likewise, COVID tongue resembles changes in the tongue, described in pellagra, ranging from geographic type lesions to general atrophy of the lingual papillae or marginal atrophy of the tongue [131,135].…”

Section: Mucocutaneous and Gastrointestinal Manifestationsmentioning

confidence: 99%

COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Kujundžić

2022

IJMS

View full text Add to dashboard Cite

Immune response to SARS-CoV-2 and ensuing inflammation pose a huge challenge to the host’s nicotinamide adenine dinucleotide (NAD+) metabolism. Humans depend on vitamin B3 for biosynthesis of NAD+, indispensable for many metabolic and NAD+-consuming signaling reactions. The balance between its utilization and resynthesis is vitally important. Many extra-pulmonary symptoms of COVID-19 strikingly resemble those of pellagra, vitamin B3 deficiency (e.g., diarrhoea, dermatitis, oral cavity and tongue manifestations, loss of smell and taste, mental confusion). In most developed countries, pellagra is successfully eradicated by vitamin B3 fortification programs. Thus, conceivably, it has not been suspected as a cause of COVID-19 symptoms. Here, the deregulation of the NAD+ metabolism in response to the SARS-CoV-2 infection is reviewed, with special emphasis on the differences in the NAD+ biosynthetic pathway’s efficiency in conditions predisposing for the development of serious COVID-19. SARS-CoV-2 infection-induced NAD+ depletion and the elevated levels of its metabolites contribute to the development of a systemic disease. Acute liberation of nicotinamide (NAM) in antiviral NAD+-consuming reactions potentiates “NAM drain”, cooperatively mediated by nicotinamide N-methyltransferase and aldehyde oxidase. “NAM drain” compromises the NAD+ salvage pathway’s fail-safe function. The robustness of the host’s NAD+ salvage pathway, prior to the SARS-CoV-2 infection, is an important determinant of COVID-19 severity and persistence of certain symptoms upon resolution of infection.

show abstract

Symmetrische bullöse akrale Erytheme bei einer 58-jährigen alkoholabhängigen Frau

Cited by 2 publications

References 7 publications

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

Contact Info

Product

Resources

About