Symmetrical Location Characteristics of Corticospinal Tract Associated With Hand Movement in the Human Brain

Lee, Dong‐Hoon; Lee, Do-Wan; Han, Byoung Hee

doi:10.1097/md.0000000000003317

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…It has been reported that there are functional and structural differences in the cerebral hemispheres of the right-and left-handed patients [4,5,10,11,16]. In corticospinal tract evaluation using DTI, asymmetry was observed to be associated with the dominant hand [12,16]. Similarly, van der Zwaag et al [18] found that lateralised hand motor movement has a greater impact on the cerebellar lobules 5 and 8 more.…”

Section: Introductionmentioning

confidence: 95%

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Evaluation of relationship between middle cerebellar peduncle asymmetry and dominant hand by diffusion tensor imaging

Polat

2019

Folia Morphol

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Background: The aim of the study was to evaluate middle cerebellar peduncle (MCP) asymmetry by diffusion tensor imaging (DTI) according to the dominant hand. Materials and methods: Sixty-four volunteers who met the exclusion and inclusion criteria were prospectively evaluated by DTI. Circular voxels of interest were drawn at the right and left MCP levels for all volunteers. The software automatically calculated the median values of fractional anisotropy (FA), mean diffusivity (MD), and number of fibres (NF). The volunteers were categorised as the right-handed (n = 44) and left-handed (n = 20) groups using the Dellatolas test. The mean values of FA, MD and NF were statistically compared between the two sides and the two groups. Results: In both groups, the mean value of FA for the right MCP was significantly higher than the left MCP (p = 0.0016 and p = 0.0032 for the right-and left-handed groups, respectively). In both groups, no significant difference was observed between the right and left MCPs in terms of MD and NF (p = 0.75, p = 0.69 and p = 0.96, p = 0.46, respectively). There was also no statistically significant difference between the groups for the mean values of FA, MD and NF of each MCP (p = 0.74, p = 0.26 and p = 0.26, respectively for the right MCP and p = 0.78, p = 0.37 and p = 0.54, respectively for the left MCP). Conclusions: There is an asymmetry between the mean FA values of the right and left MCP. However, this asymmetry is independent of the dominant hand. (Folia Morphol 2019; 78, 3: 481-486)

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Section: Introductionmentioning

confidence: 95%

“…In consecutive hand movements, the corticospinal and MCP tracts work in coordination [12,15,16]. It has been reported that there are functional and structural differences in the cerebral hemispheres of the right-and left-handed patients [4,5,10,11,16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of relationship between middle cerebellar peduncle asymmetry and dominant hand by diffusion tensor imaging

Polat

2019

Folia Morphol

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“…Diffusion tensor imaging (DTI) is used to quantitatively measure the structural connectivity of white matter tracts and provide information of cellular integrity. [ 7 – 9 ] Decreased fractional anisotropy (FA) has been consistently proven in the affected corticospinal tract (CST) across studies in subcortical stroke involving motor pathways. [ 10 , 11 ] The resting-state functional connectivity (FC) is another widely used technique to evaluate the temporal correlations between any pair of predefined brain regions.…”

Section: Introductionmentioning

confidence: 99%

Altered structural and functional connectivity between the bilateral primary motor cortex in unilateral subcortical stroke

Zhang

Li²,

Ning³

et al. 2016

Medicine

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A large number of functional imaging studies have focused on the understanding of motor-related neural activities after ischemic stroke. However, the knowledge is still limited in the structural and functional changes of the interhemispheric connections of the bilateral primary motor cortices (M1s) and their potential influence on motor function recovery following stroke.Twenty-four stroke patients with right hemispheric subcortical infarcts and 25 control subjects were recruited to undergo multimodal magnetic resonance imaging examinations. Structural impairments between the bilateral M1s were measured by fractional anisotropy. Functional changes of the bilateral M1s were assessed via M1-M1 resting-state functional connectivity. Task-evoked activation analysis was applied to identify the roles of the bilateral hemispheres in motor function recovery. Compared with control subjects, unilateral subcortical stroke patients revealed significantly decreased fractional anisotropy and functional connectivity between the bilateral M1s. Stroke patients also revealed higher activations in multiple brain regions in both hemispheres and that more regions were located in the contralesional hemisphere.This study increased our understanding of the structural and functional alterations between the bilateral M1s that occur in unilateral subcortical stroke and provided further evidence for the compensatory role played by the contralesional hemisphere for these alterations during motor function recovery.

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“…A study elucidated the symmetrical characteristics of the CST in bilateral hemispheres using probabilistic ber tracking method. They clearly showed that the hand CST had symmetric structures in bilateral hemispheres [51]. When the researches emphasized different functions of the brain, especially the language, the two hemispheres are asymmetrical.…”

Section: Limitations and Expectationsmentioning

confidence: 98%

Patterns of white matter degeneration in remote brain areas from the basal ganglion lesion of ischemic stroke patients with motor impairment

Cao¹,

Wang

Chen

et al. 2020

Preprint

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Background: Diffusion tensor imaging (DTI) studies have revealed distinct white matter characteristics of the brain following diseases. Beyond the lesion-symptom mapping, recent studies have demonstrated extensive structural and functional alterations of remote areas to local lesions caused by stroke in the brain. Here, we further investigated the structural changes from a global level using DTI data through multivariate pattern analysis (MVPA) and network-based statistic (NBS). Methods: Ten ischemic stroke patients with basal ganglia lesions and motor dysfunctions and eleven demographically matched adults as controls underwent brain Magnetic Resonance Imaging scans. DTI data were processed to obtain fractional anisotropy (FA) maps and MVPA was used to explore brain regions that play an important role in classification based on FA maps. The white matter (WM) structural network was constructed by the deterministic fiber tracking approach according to the Automated Anatomical Labeling (AAL) atlas. NBS was used to explore differences in structural networks between groups. Results: MVPA applied to FA images correctly identified stroke patients with a statistically significant accuracy of 100% (P≤0.001). Compared with the controls, the study patients showed FA reductions in the perilesional basal ganglia and brainstem, with a few showing reductions in bilateral frontal lobes. Using NBS, we found a significant decrease in FA-weighted WM subnetwork in stroke patients. Conclusions: We identified some patterns of WM degeneration affecting brain areas remote to the ischemic lesion, revealing the abnormal organization of WM network in stroke patients, which may be helpful for the understanding of the neural mechanisms of stroke sequela.

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Symmetrical Location Characteristics of Corticospinal Tract Associated With Hand Movement in the Human Brain

Cited by 7 publications

References 27 publications

Evaluation of relationship between middle cerebellar peduncle asymmetry and dominant hand by diffusion tensor imaging

Evaluation of relationship between middle cerebellar peduncle asymmetry and dominant hand by diffusion tensor imaging

Altered structural and functional connectivity between the bilateral primary motor cortex in unilateral subcortical stroke

Patterns of white matter degeneration in remote brain areas from the basal ganglion lesion of ischemic stroke patients with motor impairment

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