Symmetrical Intrauterine Growth Retardation Is Not Symmetrical: Organ-Specific Gravimetric Deficits in Midtrimester and Neonatal Trisomy 18

Johnson, Mark P.; Barr, Mason; Qureshi, Faisal; Drugan, Arie; Evans, Mark I.

doi:10.1159/000263432

Cited by 11 publications

(5 citation statements)

References 5 publications

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“…A number of these analyses have been reported [Johnson et al, 1989;Pridjian et al, 1991;Barr, 1994aBarr, ,b, 1997a. Here I will explore the occurrence of visceromegaly among fetuses with certain types of anomalies and those sharing some particular gestational experiences or maternal characteristics.…”

Section: Introductionmentioning

confidence: 99%

Correlates of prenatal visceromegaly

Barr

1998

Am. J. Med. Genet.

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Aside from recognized overgrowth syndromes, instances of visceromegaly are not uncommon at perinatal autopsy. The database of the University of Michigan Teratology Unit was screened for individual viscera exceeding the 90th centile for body and brain weight standards. The data were stratified for several maternal (hypertension, diabetes, obesity), gestational (chorioamnionitis, oligohydramnios, amniorrhaea, polyhydramnios), and fetal (body wall defect, cardiac malformation, renal malformation, diaphragmatic hernia, nonimmune hydrops, twin transfusion syndrome) characteristics and tested for statistically significant excessive numbers of heavy organs. The most striking associations were heavy adrenal glands and liver with chorioamnionitis, heavy heart with polyhydramnios and in the twin transfusion syndrome, and heavy heart and liver with nonimmune hydrops. Excessive brain weight for body weight had a number of correlations, each most likely reflecting growth restriction with sparing of brain growth.

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Section: Introductionmentioning

confidence: 99%

Correlates of prenatal visceromegaly

Barr

1998

Am. J. Med. Genet.

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“…We believe that this is the first descrip tion of secondary arrest of growth in trisomy 18 sequence. A previous report [7], analyzing the weight'of fetal organs in midtrimester and neonatal trisomy 18, also suggested that IUGR associated with aneuploid fetuses fol lows a pattern that is dynamic in nature and may change through the course of pregnancy.…”

Section: Discussionmentioning

confidence: 91%

Changing Dysmorphology of Trisomy 18 during Midtrimester

1993

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A fetus affected by trisomy 18 was observed serially on ultrasound from 14 to 21 weeks of gestation. The earliest and sole dysmorphic feature noted at 14 weeks of gestation were non-septated nuchal cysts. At 17 weeks the ultrasound examination was considered normal. However, at 21 weeks gestation, bilateral choroid plexus cysts, clubfoot, growth retardation and overlapping fingers were observed. These findings suggest that the dysmorphology associated with trisomy 18 is dynamic in nature and may change along the course of pregnancy.

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“…pre-eclampsia). These findings have been challenged, however, with studies showing asymmetrical growth associated with aneuploidy 14 , symmetrical growth associated with pre-eclampsia 15 and evidence of morbidity despite brain sparing in asymmetrical growth-restricted fetuses 16 .…”

Section: Morphologic Heterogeneity In Growth Restriction and Excessiv...mentioning

confidence: 99%