Symmetrical Acyclic Aryl Aldazines with Antibacterial and Antifungal Activity

Abstract

ABSTRACT

Catalyst‐Free One‐Pot Tandem Reduction of Oxo and Ene/Yne Functionalities by Hydrazine: Synthesis of Substituted Oxindoles from Isatins

“…[21] It appears from our results that the tandem reduction of the oxo and ene/yne functionalities by using hydrazine is unique to N-(2-alkenyl)/propargylisatins, for which the reduction of the C3 oxo group involves the well-known Wolff-Kishner mechanism, and the reduction of the olefinic group is facilitated by the in situ formation of a diimide (created by the aerobic oxidation of hydrazine hydrate), which is consistent with the previously reported mechanism. Interestingly, such compounds, that is, 2-methoxy-6-(prop-2ynyloxy)benzaldehyde (3), underwent condensation with hydrazine to produce aldazine 4 under the reaction conditions.…”

Spectral and conformational studies on 3-pyridinealdazine by DFT approach

“…Two sharp singlets exhibit at 8.72 and 8.70 ppm are assigned to H(4) and H (5) azomethine proton and pyridine ring proton. A doublet centered at 8.12 ppm is corresponding to H(8) proton.…”

“…The chemistry of carbon nitrogen double bond of hydrazone is becoming the backbone of condensation reaction in benzo-fused Nheterocycles [3] also it constitutes an important class of compounds for new drug development [4]. A number of heterocyclic compounds have been shown to possess pharmacological activities [5][6][7]. Azines, R1R2C=N-N=CR1R2, have achieved great significance in organic synthesis [8][9][10][11][12].…”

Phytochemical Investigation of Methanolic Extract of Cassia fistula Leaves

“…The nutrient broth media with three drops of Tween 80 and ciprofloxacin were used as negative and positive control, respectively for antibacterial activity and Tween 80 and Fluconazole used as a negative and positive controle, respectively for antifungal activity. [27][28][29][30][31]…”