Mode division multiplexing (MDM) may be used to increase the capacity of multimode fiber interconnects for data centers. This paper demonstrates the importance of controlling the channel spacing of a MDM system capitalizing on Hermite-Gaussian (HG) modes in order to mitigate modal dispersion and minimize the average system bit-error rate. The effect of channel spacing of a 25-channel hybrid MDM-wavelength division multiplexing (WDM) system was examined through the x-index and y-index separations of Hermite polynomials of HG modes for different MMF lengths. Simulations prove that by controlling the index separations of the Hermite polynomials, acceptable BER was achieved for 25Gb/s data transmission for a distance of 800 meters for a 25-channel HG-based MDM-WDM system at a center wavelength of 1550.12nm. The optimal x-index and y-index Hermite polynomial separations for the HG modes are 2, 3 and 4.