Symmetric polyarthritis associated with heterophile‐negative infectious mononucleosis

Sigal, Leonard H.; Steere, Allen C.; Niederman, James C.

doi:10.1002/art.1780260416

Cited by 16 publications

(2 citation statements)

References 18 publications

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“…In Einzelfällen gelang auch der kulturdie Nachweis von Rubella-Virus (Weibel et al 1969;Grahame et al 1983), Vaccinia-Virus (Silby et al 1965), Varicella-Virus (Priest et al 1978Zytomegalievirus (Hamermanll et al 1982;Friedman et al 1980), Echoviren (Kujala lind Newman 1985) und Parvoviren (Simpson et al 1984) in Gelenkpunktaten arthritischer Patienten. Arthritogene Eigenschaften werden auch dem Hepatitis-B-Virus, dem Epstein-Barr-Virus (Sigal et al 1982), Coxsackie-B-Viren (Hurst et al 1983), dem Ross-River-Virus (Bennett et al 1983) und Adenoviren (Fraser et al 1985 zugeschrieben. Die Genome mehrerer dieser Viren wie HBV-DNA (Seelig et al 1990a), Röteln-RNA (Carman et al 1989), CMV-DNA (Olive et al 1989b;Porter-Jordan et al 1990), Parvovirus B19-DNA (Clewley et al 1989;Seelig et al 1990) und EBV-DNA (Saito et al 1989) lassen sich heute routinemäßig mit der PCR nachweisen (Tab.…”

Section: Diagnostik Und Difterentialdiagnostik Bei Reaktiven Arthritidenunclassified

Polymerase-Ketten-Reaktion (PCR) - Einsatz bei der Diagnostik und Differentialdiagnostik reaktiver Arthritiden

Seelig¹,

Ehrfeld²,

Seelig³

et al. 1990

Akt Rheumatol

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Section: Diagnostik Und Difterentialdiagnostik Bei Reaktiven Arthritidenunclassified

Polymerase-Ketten-Reaktion (PCR) - Einsatz bei der Diagnostik und Differentialdiagnostik reaktiver Arthritiden

Seelig¹,

Ehrfeld²,

Seelig³

et al. 1990

Akt Rheumatol

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“…Infectious mononucleosis (IM), which is the acute clinical manifestation of EBV, is often characterized by low-grade fever, malaise, lymphadenopathy, splenomegaly, and occasionally symmetrical arthralgias. 3 It is a point of contention whether EBV is a trigger for new-onset SLE, or if immune-impaired patients with autoimmune disorders such as SLE are more likely to have recurrent IM infections. 4 This is because both diseases can have similar presentations, which again points to a possible association between the 2 disease processes.…”

Section: Introductionmentioning

confidence: 99%

Development of Systemic Lupus Erythematosus After Infectious Mononucleosis in a 64-Year-Old Woman

Wang

Singh

2020

Journal of Investigative Medicine High Impact Case Reports

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by heterogeneous symptoms that can manifest in any organ, and often presents at a young age. Infectious mononucleosis (IM) is the acute clinical manifestation of Epstein–Barr virus (EBV). It is characterized by low-grade fever, malaise, lymphadenopathy, splenomegaly, and occasionally symmetrical arthralgias. It has been proposed that EBV is a trigger for new-onset SLE, and patients with autoimmune disorders such as SLE are more likely to have recurrent IM infections. The patient, a 64-year old Caucasian female who’s only past medical history was hypertension, developed several months–long period of vague symptoms, including fatigue, malaise, nausea, and nonbilious vomiting with oral intake. She presented with symmetrical polyarthritis involving the hands and elbows, with no history of arthritis before this episode. At the 5-month follow-up, she presented with worsening arthritis bilaterally in her elbows and in her right knee. For several decades, there has been a theoretical association between EBV and SLE, with EBV thought to be one of the many possible triggers for development of SLE. Based on the disease course, we theorize that the patient’s IM and EBV infection led to development of SLE. A small fraction of SLE cases have been reported in literature to be associated with EBV. This case adds to that literature with EBV triggering development of SLE in a seemingly previously asymptomatic patient.

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Cellular Immune Events in the Joints of Patients with Rheumatoid Arthritis

Zvaifler

Silver

1985

Immunology of Rheumatic Diseases

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Symmetric polyarthritis associated with heterophile‐negative infectious mononucleosis

Cited by 16 publications

References 18 publications

Polymerase-Ketten-Reaktion (PCR) - Einsatz bei der Diagnostik und Differentialdiagnostik reaktiver Arthritiden

Polymerase-Ketten-Reaktion (PCR) - Einsatz bei der Diagnostik und Differentialdiagnostik reaktiver Arthritiden

Development of Systemic Lupus Erythematosus After Infectious Mononucleosis in a 64-Year-Old Woman

Cellular Immune Events in the Joints of Patients with Rheumatoid Arthritis

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