Let P be the Ornstein-Uhlenbeck semigroup associated with the stochastic Cauchy problemwhere A is the generator of a C 0 -semigroup S on a Banach space E, H is a Hilbert subspace of E, and W H is an H-cylindrical Brownian motion. Assuming that S restricts to a C 0 -semigroup on H, we obtain L p -bounds for D H P (t). We show that if P is analytic, then the invariance assumption is fulfilled. As an application we determine the L p -domain of the generator of P explicitly in the case where S restricts to a C 0 -semigroup on H which is similar to an analytic contraction semigroup. The results are applied to the 1D stochastic heat equation driven by additive space-time white noise.Here i : H ֒→ E is the inclusion mapping. A necessary and sufficient condition for the existence of a weak solution is that the operators I t : L 2 (0, t; H) → E, I t g := t 0 S(s)ig(s) ds, 1991 Mathematics Subject Classification. 47D07 (35R15, 42B25, 60H15).