Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis

Abstract

BackgroundSymmetric dimethylarginine (SDMA) is a methylated arginine derived from intranuclear methylation of l‐arginine by protein‐arginine methyltransferase and released into circulation after proteolysis. It is primarily eliminated by renal excretion, and its concentration is highly correlated with glomerular filtration rate (GFR) in animals and humans and is an earlier indicator of kidney dysfunction than serum creatinine concentration (sCr).ObjectivesTo evaluate and quantify the effects of IV fluid therapy (IF) or intermittent hemodialysis (IH) on renal function in a randomized group of dogs previously diagnosed with International Renal Interest Society (IRIS) stage 4 chronic kidney disease (CKD).AnimalsTwenty‐four client‐owned dogs with naturally occurring CKD.MethodsSerum from 14 dogs treated by IH and 10 dogs treated with IF was submitted for measurement of sCr and SDMA. Dogs in each treatment group received up to 5 treatment sessions, administered 48 hours apart.ResultsSignificant differences (P ≤ .05) were seen between treatment groups, but dogs from the IH group were the most affected based on SDMA (P < .001), sCr (P < .001), and blood urea (P < .001) concentrations. Furthermore, for each 10% increase in urea reduction ratio, there was a 6.2 μg/dL decrease in SDMA (P = .002).Conclusions and Clinical ImportanceAlthough SDMA is dialyzable biomarker and despite its removal by IH, SDMA correlates better with renal function than does sCr in dogs with CKD undergoing IF and IH.

Outcome of Acquired Fanconi Syndrome Associated with Ingestion of Jerky Treats in 30 Dogs

“…The lacking association related to creatinine and urea concentrations indicate that the renal disease induced in dogs by excessive ingestion of jerky treats does not significantly affect the glomerulus, which supports the previously reported necropsy results, in which, renal damage was primarily located to the proximal tubules [ 22 ]. However, as the possibility of an association between duration of feeding jerky and SDMA still remains and considering that SDMA is generally considered a more sensitive marker of glomerular damage than creatinine [ 32 , 33 , 34 ], SDMA should be further evaluated in future prospective JFS studies.…”

Atualidades Na Saúde E Bem-Estar Animal, Volume 9

“…Além disso, pacientes com DRC que podem necessitar de HDI são aqueles que sofreram nefrotoxicidade aguda (envenenamento, overdose de medicamentos, leptospirose etc. ), ou então nos quais se objetive estabilizar a condição, permitindo intervenções cirúrgicas ou terapêuticas com potencial nefrotóxico, como em pacientes oncológicos submetidos à quimioterapia (VIEIRA et al, 2019).…”

“…A SDMA não sofre influência da massa muscular esquelética, o que faz com que sua avaliação em estádios mais avançados da DRC, desde que o paciente esteja estável, possa auxiliar na identificação de casos em progressão, principalmente relacionados à perda de massa magra, nos quais, por consequência, a creatinina sérica pode estar reduzida (CRIVELLENTI; GIOVANINNI, 2021) Vieira et al (2019). relatou que a SDMA pode ser utilizada em três diferentes formas: como marcador de diagnóstico precoce, como marcador endógeno de TFG e como marcador de monitoração da DRC.…”

A Hemodiálise Como Tratamento Em Cães Com Insuficiência Renal

“…Os biomarcadores são variáveis biológicas mensuradas que atuam como indicadores de processos normais, patológicos ou em resposta a um tratamento (SOUZA, 2017). De acordo com Vieira et al (2019), os principais biomarcadores envolvidos no diagnóstico precoce das doenças renais são aqueles que comprovam e demonstram: uma redução da taxa de filtração glomerular (TFG), a presença de lesões glomerulares, tubulares e em ductos, bem como a presença de doenças autoimunes antecedentes a lesão renal intrínseca.…”