Symbolic regression metamodel-based optimal design of patient-specific spinal implant (pedicle screw fixation)

Biswas, Jayanta Kumar; Kalita, Kanak; Roy-Chowdhury, Amit K.

doi:10.1007/s00366-020-01090-z

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Therefore, it is necessary to realize the combination optimization of highway alignment and vertical horizontal alignment in mountainous areas, use the mountain terrain to determine the slope profile, and select appropriate construction methods and schemes based on the analysis of terrain, geology and other factors on the number of subgrade fill and excavation, soil type, hydrological conditions and climatic and environmental characteristics, and design in combination with the characteristics of the highway itself, On the premise of ensuring the quality and safety of highway engineering, we should reasonably arrange the relationship between various investment scales and structure proportions. Finally, we should determine a reasonable, feasible and cost-effective route plan in combination with the engineering geological conditions, the surrounding environment and the highway grade, so as to ensure that the expressway can be carried out in an orderly manner during the design process and achieve the expected goals [17,18]. The roadside vibration belt can only be installed when the length of the section without lateral traffic flow interference is greater than a certain value.…”

Section: Expressway Optimization Algorithmmentioning

confidence: 99%

Optimal Design of Mountain Expressway Based on Natural Environment Protection

2020

NEP

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Optimizing the design of mountain roads can improve the service life of highways, reduce the maintenance costs in the later period, and promote the economic development of mountain areas. Based on the actual situation and data analysis of mountain expressway lines, this paper summarizes the natural ecological environment conditions and topographic and geomorphic features involved in the geological survey report, and discusses and studies the highway design according to the natural environment characteristics along the line. On the premise of ensuring the safety and reliability of the project, the ecological scheme is adopted to apply the optimal design scheme of mountain expressway, Under the condition that the base is stable and the landscape along the line is not strongly affected, the high dam scheme can be selected by increasing the base compactness, reducing waste and waste utilization, so as to reduce the project cost.

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Section: Expressway Optimization Algorithmmentioning

confidence: 99%

Optimal Design of Mountain Expressway Based on Natural Environment Protection

2020

NEP

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“…The usual surgical choice of customized cage fixation is anterior cervical discectomy and fusion (ACDF) for cervical spondylosis with disc herniation or other ventrally generated cervical infections that are not identified by conventional therapy [1][2][3][4]. Age-related wear and tear on the cervical spinal discs may lead to degenerative alterations.…”

Section: Introductionmentioning

confidence: 99%

“…The risk factors concerning the adjacent segment degeneration (ASD) and diseases can be reduced to larger extent by maintaining the cervical lordosis during ACDF for cage fixation treatments [2,9,10]. The safe and successful cage fixation for ACDF surgery benefits patients with cervical disc degenerative disease by easing their discomfort and regaining function [3,4]. By using cage implants to anchor the neighbouring vertebrae, cage prevents mobility between the vertebrae [2,4].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical analysis of a single-level customized cage screw fixation for anterior cervical discectomy and fusion in the cervical spine: an in-silico study

Kumar

2023

Biomed. Phys. Eng. Express

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The usual surgical choice of customized cage fixation is anterior cervical discectomy and fusion (ACDF) for cervical spondylosis with disc herniation. The safe and successful cage fixation for ACDF surgery benefits patients with cervical disc degenerative disease by easing their discomfort and regaining function. The cage prevents mobility between the vertebrae by using cage fixation to anchor the neighbouring vertebrae. The goal of the current study is to develop a customized cage-screw implant for single-level cage fixation at C4-C5 level of the cervical spine (C2-C7). The Finite Element Analysis (FEA) is performed for the intact and implanted cervical spine and analysed the flexibility, stress of the implant and implant adjacent bone during three physiological loading conditions being analysed. Lower surface of the C7 vertebrae is fixed and 50 N compressive force with 1 Nm moment are applied on the C2 vertebrae for simulated lateral bending, axial rotation and flexion-extension. The flexibility is decreased at single level of fixation (C4-C5 level) by 64% to 86%, as compared to natural cervical spine. The flexibility is increased 3% to 17% at the nearest levels of fixation. The maximum Von Mises stress in PEEK cage varies from 24 to 59 MPa and for Ti-6Al-4V screw the stress varies from 84MPa to 121MPa which are far below the yield stress of PEEK (95MPa) and Ti-6Al-4V (750MPa).

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“…To quantify screw hold, axial load-to-failure pullout tests (Burval et al, 2007;Aichmair et al, 2017;Lai et al, 2018), different cyclic toggling test setups simulating more physiological loading conditions (Weiser et al, 2017;Liebsch et al, 2018;Spirig et al, 2021), as well as finite element simulations (Biswas et al, 2018;Chevalier et al, 2018;Van den Abbeele et al, 2018;Widmer et al, 2020;Biswas et al, 2022) have been employed to guide surgeons, researchers, and the industry into the direction of optimized screw fixation strength. While different aspects of screw hold can be analyzed with these methods, they usually attempt to investigate the behavior of the bone-screw interaction at a "global" level.…”

Section: Introductionmentioning

confidence: 99%

Location of pedicle screw hold in relation to bone quality and loads

Cornaz

Farshad

Widmer

2022

Front. Bioeng. Biotechnol.

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Introduction: Sufficient screw hold is an indispensable requirement for successful spinal fusion, but pedicle screw loosening is a highly prevalent burden. The aim of this study was to quantify the contribution of the pedicle and corpus region in relation to bone quality and loading amplitude of pedicle screws with traditional trajectories.Methods: After CT examination to classify bone quality, 14 pedicle screws were inserted into seven L5. Subsequently, Micro-CT images were acquired to analyze the screw’s location and the vertebrae were split in the midsagittal plane and horizontally along the screw’s axis to allow imprint tests with 6 mm long sections of the pedicle screws in a caudal direction perpendicular to the screw’s surface. Force-displacement curves in combination with the micro-CT data were used to reconstruct the resistance of the pedicle and corpus region at different loading amplitudes.Results: Bone quality was classified as normal in three specimens, as moderate in two and as bad in two specimens, resulting in six, four, and four pedicle screws per group. The screw length in the pedicle region in relation to the inserted screw length was measured at an average of 63%, 62%, and 52% for the three groups, respectively. At a calculated 100 N axial load acting on the whole pedicle screw, the pedicle region contributed an average of 55%, 58%, and 58% resistance for the normal, moderate, and bad bone quality specimens, respectively. With 500 N load, these values were measured at 59%, 63%, and 73% and with 1000 N load, they were quantified at 71%, 75%, and 81%.Conclusion: At lower loading amplitudes, the contribution of the pedicle and corpus region on pedicle screw hold are largely balanced and independent of bone quality. With increasing loading amplitudes, the contribution of the pedicle region increases disproportionally, and this increase is even more pronounced in situations with reduced bone quality. These results demonstrate the importance of the pedicle region for screw hold, especially for reduced bone quality.

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Symbolic regression metamodel-based optimal design of patient-specific spinal implant (pedicle screw fixation)

Cited by 7 publications

References 28 publications

Optimal Design of Mountain Expressway Based on Natural Environment Protection

Optimal Design of Mountain Expressway Based on Natural Environment Protection

Biomechanical analysis of a single-level customized cage screw fixation for anterior cervical discectomy and fusion in the cervical spine: an in-silico study

Location of pedicle screw hold in relation to bone quality and loads

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