Symbol Digit Modalities Test adaptation for Magnetic Resonance Imaging environment: A systematic review and meta-analysis

Silva, P.H.R.; Spedo, Carina Tellaroli; Barreira, Amilton Antunes; Leoni, Renata Ferranti

doi:10.1016/j.msard.2018.01.014

Cited by 53 publications

(29 citation statements)

References 59 publications

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“…While other studies have reported correlations between ToM and cognitive performance (e.g., Isernia et al, 2019;Roca et al, 2014), the current study is the first to use mediation analysis to demonstrate that the group differences in cognitive ToM are explained by cognitive ability. This finding may suggest a common pattern of neurodegeneration substrative of both cognitive and social cognitive processes in MS; this is supported by recent neuroanatomical evidence that atrophy in the brain regions contributing to social cognitive deficits in MS overlap with those that are important for memory and processing speed (Ciampi et al, 2018;Kollndorfer et al, 2013;Silva et al, 2018). Interestingly, affective ToM was not significantly associated with general cognitive ability, suggesting that inferring an actor's thoughts and intentions may be more cognitively demanding than inferring their emotions, or may rely on distinct neural pathways that are differentially affected by MS (Abu-Akel & Shamay-Tsoory, 2011).…”

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confidence: 56%

Cognitive but Not Affective Theory of Mind Deficits in Progressive MS

Lancaster

Stone

Genova

2019

J Int Neuropsychol Soc

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Objective:Social cognitive deficits are an important consequence of multiple sclerosis (MS), yet our understanding of how these deficits manifest in progressive MS is currently limited. To this end, we examined theory of mind (ToM) ability in a sample of individuals with progressive MS using an ecologically valid virtual assessment tool that allows for delineation of cognitive ToM (inferring thoughts and intentions of others) from affective ToM (inferring emotions of others).Methods & Results:We compared 15 individuals with progressive MS and 15 healthy controls on their ToM ability using the Virtual Assessment of Mentalising Ability. We found that, relative to healthy controls, participants with progressive MS were impaired in cognitive ToM, but not in affective ToM. Furthermore, we found that the MS participants’ deficits in cognitive ToM were mediated by their general cognitive ability such that poor cognitive ToM ability in MS was explained by poor performance on tests of memory and processing speed.Conclusions:Our findings demonstrate that ToM deficits in progressive MS may be limited to cognitive ToM, while affective ToM is conserved. This could be attributable to the MS-related deficits in general cognitive ability, which appear to negatively affect only the cognitive component of ToM.

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confidence: 56%

Cognitive but Not Affective Theory of Mind Deficits in Progressive MS

Lancaster

Stone

Genova

2019

J Int Neuropsychol Soc

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“…A reduced anti-coupling between iCAP5 AntDMN and iCAP2 Aud/SM correlated with a worse performance at CVLT-II but better for SDMT. While the former would indicate that the segregation between anterior DMN and auditory regions influences CVLT-II performance, the latter again suggests a compensatory role for the iCAP5 AntDMN , in this case involving its synchronicity with sensory-motor regions, probably the supplementary motor area functionally involved during SDMT (Silva et al ., 2018). We also confirmed an association between reduced dynamic of the visual network and cognitive impairment, previously observed in a study on a large sample of patients with relapsing-remitting, PP and SP MS (Eijlers et al ., 2019).…”

Section: Discussionmentioning

confidence: 99%

Altered anterior default mode network dynamics in progressive multiple sclerosis

Bommarito

Tarun

Farouj

et al. 2020

Preprint

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Functional reorganization at the progressive stage of multiple sclerosis has received limited attention, despite the fact that functional changes are known to occur. Characterizing large-scale network dynamics at rest has the potential to provide new insights into the complexity of such functional alterations. In this case-control study, we explored the dynamic properties of large-scale functional networks during rest in 25 healthy controls and 32 patients with progressive multiple sclerosis, using the innovation-driven co-activation patterns. Thirty-five subjects also underwent a one-year follow-up examination. Partial least squares correlation analysis was applied to explore the relationship between functional dynamics and clinical disability. We observed a reduced dynamic engagement of the anterior default mode network and its coupling with the executive-control network in patients with progressive multiple sclerosis compared to controls, at baseline and follow-up. The global and motor disabilities were related to functional dynamics of subcortical, sensory-motor and posterior default mode network, while the cognitive disability was associated to the altered dynamics of anterior default mode, visual and temporal networks. These findings reveal that the anterior default mode functional recruitment and its interaction with other networks play a major role in the functional reorganization occurring during the progressive stage of multiple sclerosis. Also, the dynamic properties of large-scale functional networks are steady over one year and unveil the intricate relationship between brain function and clinical disability.

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“…Previous event-related fMRI studies revealed activation in the fronto-parietal network and visual areas during SDMT tests, including the dlPFC, cuneus, and lingual gyrus (Forn et al, 2009, 2013; Akbar et al, 2016; Dobryakova et al, 2016). The SDMT requires the visual tracking, scanning, and attention regulated by the visual areas, as well as the attentional control, memory coding, working memory, and inferential reasoning involving the dlPFC (Silva et al, 2018). In the current study, the enhanced FC between the dlPFC and cuneus was also associated with the SDMT performances in the patients with SNHL, suggesting that the stronger functional integration between the dlPFC and visual cortex also contributed to faster information processing speed in SNHL.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal-Temporal Pathway Mediates the Cross-Modal and Cognitive Reorganization in Sensorineural Hearing Loss With or Without Tinnitus: A Multimodal MRI Study

et al. 2019

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Objective: Hearing loss, one main risk factor of tinnitus and hyperacusis, is believed to involve significant central functional abnormalities. The recruitment of the auditory cortex in non-auditory sensory and higher-order cognitive processing has been demonstrated in the hearing-deprived brain. The dorsolateral prefrontal cortex (dlPFC), which has dense anatomical connections with the auditory pathway, is known to play a crucial role in multi-sensory integration, auditory regulation, and cognitive processing. This study aimed to verify the role of the dlPFC in the cross-modal reorganization and cognitive participation of the auditory cortex in long-term sensorineural hearing loss (SNHL) by combining functional and structural measurements.Methods: Thirty five patients with long-term bilateral SNHL and 35 matched healthy controls underwent structural imaging, resting-state functional magnetic resonance imaging (rs-fMRI), diffusion tensor imaging (DTI), and neuropsychological assessments. Ten SNHL patients were with subjective tinnitus.Results: No differences in gray matter volume, spontaneous neural activity, or diffusion characteristics in the dlPFC were found between the SNHL and control groups. The functional connectivity (FC) between the dlPFC and the auditory cortex and visual areas, such as the cuneus, fusiform, lingual cortex, and calcarine sulcus was increased in patients with SNHL. ANOVA and post hoc tests revealed similar FC alterations in the SNHL patients with and without tinnitus when compared with the normal hearing controls, and SNHL patients with and without tinnitus showed no difference in the dlPFC FC. The FC in the auditory cortex was associated with the symbol digit modality test (SDMT) scores in the SNHL patients, which reflect attentional function, processing speed, and visual working memory. Hearing-related FC with the dlPFC was found in the lingual cortex. A tract-based spatial statistics (TBSS) analysis revealed decreased fractional anisotropy (FA) values, mainly in the temporal inferior fronto-occipital fasciculus (IFOF), which showed remarkable negative correlations with the mean hearing thresholds in SNHL.Conclusion: Higher functional coupling between the dlPFC and auditory and visual areas, accompanied by decreased FA along the IFOF connecting the frontal cortex and the occipito-temporal area, might mediate cross-modal plasticity via top-down regulation and facilitate the involvement of the auditory cortex in higher-order cognitive processing following long-term SNHL.

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Symbol Digit Modalities Test adaptation for Magnetic Resonance Imaging environment: A systematic review and meta-analysis

Cited by 53 publications

References 59 publications

Cognitive but Not Affective Theory of Mind Deficits in Progressive MS

Cognitive but Not Affective Theory of Mind Deficits in Progressive MS

Altered anterior default mode network dynamics in progressive multiple sclerosis

Prefrontal-Temporal Pathway Mediates the Cross-Modal and Cognitive Reorganization in Sensorineural Hearing Loss With or Without Tinnitus: A Multimodal MRI Study

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