Symblepharon Associated With Cyanoacrylate Tissue Adhesive

Leahey, Alan B.

doi:10.1001/archopht.1993.01090020022011

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…In summary, despite their advantages (i.e. quick, easy, and effective treatment of ocular injuries), and their frequent off-label use in ophthalmic applications, the use of cyanoacrylates has been hampered by many shortcomings including infection [62], corneal endothelial polymerization [63], granulomatous keratitis [64], dacryocystitis [65], symblepharon formation [66], and unintentional entry into the anterior chamber [67]. In addition, the non-biodegradable nature of cyanoacrylates can lead to inflammatory responses, corneal neovascularization, foreign-body reactions, and tissue necrosis.…”

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…While tissue adhesive is generally considered safe, complications can still arise. Previous reports have associated cyanoacrylate tissue adhesive with conditions such as symblepharon, infection, granulomatous keratitis, or giant papillary conjunctivitis, mostly occurring when the adhesive comes into direct contact with the cornea and conjunctival tissues [ 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparison between 2-Octyl Cyanoacrylate and Conventional Suturing for the Closure of Epiblepharon Incision Wounds in Children: A Retrospective Case–Control Study

Hsu,

Lee,

Chang

et al. 2024

JCM

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Background: Tissue adhesive has been widely used in ophthalmic surgery for various procedures, proving both effective and safe. However, no studies have compared the surgical efficacy of the tissue adhesive 2-octyl cyanoacrylate (SurgiSeal®) to that of traditional suture closure in Asian children undergoing surgery for lower lid epiblepharon. Methods: This is a single-center retrospective case-control study. Surgical correction for epiblepharon was performed on 22 patients from November 2019 to May 2023. A total of 20 patients who were followed up for at least 1 month were included for analysis. After standardized epiblepharon surgery, group A underwent wound closure with a subcuticular suture and 2-octyl cyanoacrylate, and group B underwent closure with a 6-O fast-absorbing surgical gut suture. Patients were followed up at 1, 4, and 12 weeks post-surgery. Results: A total of 10 patients (20 eyes) underwent skin closure with tissue adhesives (group A), and 10 patients (18 eyes) underwent wound closure using conventional suture material (group B). No significant differences in the sex ratio, mean age at operation, pre- and postoperative best-corrected visual acuity (BCVA), or average surgical time were observed between groups. Both groups exhibited improved postoperative BCVA, with symptom relief and a significant decrease in the severity of keratopathy after surgery. Neither recurrence nor complications were reported during follow-up. The aesthetic results were similar between groups, while caregivers of children in the tissue adhesive group expressed high satisfaction regarding the ease of postoperative care. Conclusions: Successful closure of lower lid epiblepharon surgery wounds in children can be performed using 2-octyl cyanoacrylate (SurgiSeal®). This method is simple, safe, and effective when compared to conventional sutures.

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“…A forma n-butil cianoacrilato (conhecido como Histoacryl) encontra-se comercialmente no Canadá e países da Europa. São bem tolerados no estroma corneal (7)(8) ; porém, quando injetado inadvertidamente na câ-mara anterior podem ocasionar falência endotelial (9)(10) e em contato com a conjuntiva podem desencadear a formação de simbléfaros (11) .…”

Section: Descritoresunclassified

Adesivo de cianoacrilato no tratamento de afinamentos e perfurações corneais: técnica e resultados

Felberg¹,

Lake²,

Lima³

et al. 2003

Arq. Bras. Oftalmol.

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Objetivos: Relatar a experiência obtida com o uso de adesivo de cianoacrilato em 22 casos seriados, e não comparativos, de afinamentos ou perfurações corneais de etiologia variada. Também visa descrever a técnica proposta para a aplicação do adesivo. Métodos: Foram estudados 22 olhos de 22 pacientes que apresentavam afinamentos ou perfurações corneais, tratados com adesivo de cianoacrilato (Super Bonder ® -Loctite, Brasil), no Departamento de Oftalmologia da Santa Casa de São Paulo, entre outubro de 1998 e abril de 2000. Os parâmetros avaliados foram: idade do paciente, sexo, acuidade visual antes e após aplicação do adesivo (com a correção em uso), medida (em milímetros) da perfuração ou afinamento, doença ocular que levou diretamente à necessidade da aplicação do adesivo, necessidade de "patch" ou transplante tectônico após tentativa de selar a lesão com o adesivo, número de aplicações realizadas, tempo de permanência da cola, efeitos indesejáveis após a colocação do adesivo e evolução do caso. Resultados: A acuidade visual dos pacientes mantevese inalterada após a aplicação da cola em 15 casos (68%). Com relação ao tamanho das lesões, a maioria pertence ao grupo que variou entre 1 e 2 milímetros (63%). As infecções constituíram a mais freqüente indicação para o uso do adesivo (50%). Doze pacientes (54%) não necessitaram transplante ou "patch" de córnea. Dos 22 olhos estudados, onze (50%) necessitaram de apenas uma aplicação do adesivo. Conclusão: No presente estudo, o cianoacrilato mostrou-se seguro e de grande utilidade na manutenção da integridade ocular em casos de afinamentos e perfurações corneais.

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Symblepharon Associated With Cyanoacrylate Tissue Adhesive

Cited by 5 publications

References 3 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

A Comparison between 2-Octyl Cyanoacrylate and Conventional Suturing for the Closure of Epiblepharon Incision Wounds in Children: A Retrospective Case–Control Study

Adesivo de cianoacrilato no tratamento de afinamentos e perfurações corneais: técnica e resultados

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