Sylimarin as hepatic protector and immunomodulator in Nile tilapia during Streptococcus agalactiae infection

Owatari, Marco Shizuo; Jesus, Gabriel Fernandes Alves; Brum, Aline; Pereira, Scheila Anelise; Lehmann, Nicollas Breda; Pereira, Ulisses de Pádua; Martins, Maurício Laterça; Mouriño, José Luiz Pedreira

doi:10.1016/j.fsi.2018.08.061

Cited by 38 publications

(37 citation statements)

References 35 publications

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“…In the present study, adding 100 mg/kg silymarin to the diet relieved live injury, as reflected by the reduction of GPT and GOT, and promoted intestinal health by suppressing proinflammatory cytokines, which contributed to growth promotion of turbot. However, a high dose of silymarin supplement did not induce higher growth performance as reported for grass carp (Xiao et al, 2017) and Nile tilapia (Owatari et al, 2018). The differential effects of silymarin at high doses might be related to the feeding habits of the fish.…”

Section: Discussionmentioning

confidence: 63%

“…(1 g/kg diet) had no effects on the enzymatic activities of CAT and SOD in Nile tilapia (Owatari et al, 2018). This might be because the fish that consumed the silymarin-supplemented feed did not suffer any type of contamination.…”

Section: Discussionmentioning

confidence: 95%

“…The antioxidant effects of silymarin might reflect its ability to directly scavenge free radicals (Asghar & Masood, ) and activate the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2)/kelch‐like ECH‐associated protein 1 (Keap1)/antioxidant response element pathways, which can regulate the expression of genes encoding antioxidant enzymes (Buelna‐Chontal & Zazueta, ; Surai, ). However, silymarin supplementation (1 g/kg diet) had no effects on the enzymatic activities of CAT and SOD in Nile tilapia (Owatari et al, ). This might be because the fish that consumed the silymarin‐supplemented feed did not suffer any type of contamination.…”

Section: Discussionmentioning

confidence: 99%

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Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Wang

Zhou

Wang

et al. 2019

J World Aquaculture Soc

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A 9‐week feeding trial was conducted using triplicate groups of turbot (6.50 ± 0.01 g) to explore the potential effects of silymarin. Three concentrations of silymarin (100, 200, and 400 mg/kg) were added to the plant protein‐based diet. Fish were randomly distributed into fiberglass tanks (30 fish per tank). The results showed that adding 100 mg/kg silymarin significantly improved the growth performance, with no effects on feed utilization. The antioxidant capacity in the liver was significantly improved in the 100 mg/kg and 200 mg/kg silymarin groups by not only inducing the activities of superoxide dismutase (SOD) and catalase but also increasing the messager RNA (mRNA) expression levels of SOD, glutathione peroxidase, and peroxiredoxin 6. Meanwhile, supplying 100 and 200 mg/kg of silymarin enhanced the heights of villi and enterocytes. Silymarin supplementation reduced the mRNA expression of interleukin‐8 and tumor necrosis factor‐α but induced the expression of transforming growth factor‐β (TGF‐β) in the intestine. These results indicated that silymarin was a potential nutraceutical that could enhance the growth performance and health status of turbot fed in a high plant protein diet. Adding 100 mg/kg silymarin to the plant protein diet achieved optimal performance in turbot.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Wang

Zhou

Wang

et al. 2019

J World Aquaculture Soc

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“…The average hematocrit was within the desirable range for the species in the early stages of cultivation, in clear water, with an average weight of 1.84 ± 0.52 g (Brum et al, 2017), and in studies with juvenile animals between 50 and 60 g (Owatari et al, 2018(Owatari et al, , 2019. Changes in hematocrit (hemoconcentrated or hemodiluted) may be related to stress (Morgan et al, 1997).…”

Section: /9mentioning

confidence: 65%

“…Thrombocytes were higher in T5, and they were much higher than those found in other studies (Ghiraldelli et al, 2006;Brum et al, 2017;Owatari et al, 2018;Owatari et al, 2019). Thrombocytes play an important role in blood clotting and in general mechanisms of inflammatory processes (Tavares-Dias and Moraes, 2007;Kayode and Shamusideen, 2010).…”

Section: /9mentioning

confidence: 75%

Nile Tilapia Nursery in a Biofloc System: Evaluation of Different Stocking Densities

et al. 2020

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This trial aimed to evaluate the growth performance and hematological parameters of Nile tilapia (Oreochromis niloticus) GIFT strain during nursery using different stock densities in a biofloc system. The experiment was conducted in circular tanks (400 L) with sexually reversed fish, weighing 6.74 ± 0.37 g, over a period of 35 days. Five treatments with three replicates each were used in a completely randomized design. The treatments were as follows: T1 (200 fishes m-3); T2 (300 fishes m-3); T3 (400 fishes m-3); T4 (500 fishes m-3), and T5 (600 fishes m-3). The fishes were fed four times a day, following a feed table for this species, with adjustments according to fish biomass. The water quality parameters total ammoniacal nitrogen, and unionized ammonia showed a significant difference (p<0.05) between the treatments with lower (T1) and higher stocking densities (T4, T5). Alkalinity was significantly higher in treatments with higher densities (T4 and T5). For hematological parameters, the number of thrombocytes was higher in T5. Hemoglobin concentration was significantly lower in T5 than in T3. The best productive indexes were found in T4, presenting final biomass of 9915.16 ± 14.80 g m-3 , apparent feed conversion rate of 1.11 ± 0.02, mean survival of 95.75 ± 0.75%, and daily mean weight gain of 0.43 ± 0.07 g. Overall, the Nile tilapia nursery in a biofloc system showed higher individual growth at densities up to 300 fishes m-3 and increased stocking density up to 500 fishes m-3 .

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Nanosystems Trends in Nutraceutical Delivery

Buya¹

2023

Advances in Novel Formulations for Drug Delivery

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Sylimarin as hepatic protector and immunomodulator in Nile tilapia during Streptococcus agalactiae infection

Cited by 38 publications

References 35 publications

Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Effects of silymarin on growth performance, antioxidant capacity and immune response in turbot (Scophthalmus maximus L.)

Nile Tilapia Nursery in a Biofloc System: Evaluation of Different Stocking Densities

Nanosystems Trends in Nutraceutical Delivery

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