Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity

Jeong, Hye Yoon; Sung, Gi‐Ho; Kim, Ji Hye; Yoon, Ju Young; Yang, Yanyan; Park, Jae Gwang; Kim, Shi Hyoung; Yi, Young-Su; Yang, Woo Seok; Yoon, Deok Hyo; Kim, Tae‐Woong; Kim, Jong-Hoon; Cho, Jae Youl

doi:10.1016/j.jep.2013.12.009

Cited by 34 publications

(18 citation statements)

References 48 publications

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“…In lipopolysaccharide (LPS)‐treated RAW264.7 cells and peritoneal macrophages, kaempferol exhibited inhibitory activity on the production of nitric oxide (NO), COX‐2, and synthase (iNOS). It additionally reduced the NF‐κB‐mediated enhancement of luciferase, activity, phosphorylation of IκBα, and nuclear translocation of p50 and p65 (Jeong et al, ).…”

Section: Health Perspectivesmentioning

confidence: 99%

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Imran

Rauf

Shah

et al. 2018

Phytotherapy Research

259

154

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Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments.

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Section: Health Perspectivesmentioning

confidence: 99%

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Imran

Rauf

Shah

et al. 2018

Phytotherapy Research

259

154

View full text Add to dashboard Cite

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“…Nine compounds from the leaves of sea mango were identified by Xiaopo et al [9], including p-hydroxybenzaldehyde, benzamide, n-hexadecane acid monoglyceride, loliolide, β-sitosterol, cerberin, neriifolin, cerleaside A, and daucosterol. This tree species has been shown to have some notable medical properties, and is used as an emetic and purgative in medicine [10][11][12], anesthesia [11], treatment of rheumatism [13], as an anti-inflammatory [14], an antioxidant, and as an analgesic [15]. It is also recognized as one of the promising non-edible feedstock plants for future production of biodiesel [16].…”

Section: Digital Signaturementioning

confidence: 99%

Phytotoxic effects of Cerbera manghas L. leaf extracts on seedling elongation of four monocot and four dicot test species

Bari

Kato‐Noguchi

2017

Acta Agrobot

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Exploration of allelochemicals with phytotoxic effects is intended to minimize a current dependency on synthetic herbicides in weed management. Several allelochemicals from the tropical tree Cerbera manghas (sea mango) have been reported as termiticides and bactericides. The present study investigated possible phytotoxic effects of C. manghas leaf extracts under laboratory conditions. Four monocots: barnyard grass (Echinochloa crus-galli), foxtail fescue (Vulpia myuros), Italian ryegrass (Lolium multiflorum), and timothy (Phleum pratense) and four dicots: alfalfa (Medicago sativa), garden cress (Lepidium sativum), lettuce (Lactuca sativa), and rapeseed (Brassica napus) were used as test species. Elongation of both shoots and roots of seedlings was measured to assess any phytotoxic effects. The results showed that the sensitivities of shoots and roots were different between the test species, and the inhibition of seedling elongation significantly increased with increasing concentration of leaf extracts of C. manghas for all the test species. The IC50 (50% inhibitory concentration) values showed that 8.50–32.30 and 4.26–34.67 mg dry weight equivalent extract mL−1 of C. manghas inhibited seedling elongation by 50%, for shoots and roots respectively. Isolation and identification of the phytotoxic substances from C. manghas are suggested for future investigation.

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“…This compound is highly contained in most edible herbal plants such as tea, fruits, and vegetables [ 13 ]. These include Allium cepa (onion), Camellia sinensis (tea), Citrus paradisi (grapefruit), Fragaria vesca (strawberry), Lactuca sativa (lettuce), and Morinda citrifolia (Indian mulberry) as well as medicinal plants such as Cerbera manghas [ 13 – 15 ]. Owing to numerous pharmacological studies due to its popularity, it has been reported that this compound is able to display antioxidative, anticancer, anti-inflammatory, and antiaging properties [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Dietary Flavonoid Kaempferol Mediates Anti‐Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets

Kim

Park

Lee

et al. 2015

Mediators of Inflammation

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Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated macrophages. In particular, molecular targets for KF action were identified by using biochemical and molecular biological analyses. KF suppressed the release of nitric oxide (NO) and prostaglandin E2 (PGE2), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of inflammatory genes encoding inducible NO synthase (iNOS), TNF-α, and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages. KF reduced NF-κB (p65 and p50) and AP-1 (c-Jun and c-Fos) levels in the nucleus and their transcriptional activity. Interestingly, it was found that Src, Syk, IRAK1, and IRAK4 responsible for NF-κB and AP-1 activation were identified as the direct molecular targets of KF by kinase enzyme assays and by measuring their phosphorylation patterns. KF was revealed to have in vitro and in vivo anti-inflammatory activity by the direct suppression of Src, Syk, IRAK1, and IRAK4, involved in the activation of NF-κB and AP-1.

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Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity

Cited by 34 publications

References 48 publications

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Chemo‐preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Phytotoxic effects of Cerbera manghas L. leaf extracts on seedling elongation of four monocot and four dicot test species

The Dietary Flavonoid Kaempferol Mediates Anti‐Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets

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