Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens

Genel, Ferah; Arslanoğlu, Sertaç; Uran, Nedret; Şaylan, Berna

doi:10.1016/s0387-7604(01)00404-1

Cited by 94 publications

(76 citation statements)

References 20 publications

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“…Valproic acid is an antiepileptic drug and has been used to treat movement disorders, including chorea. 8 As in our case 1, valproic acid can be used as a first line agent in chorea due to its superior effect compared with carbamazepine and haloperidol in patients with severe symptoms. 9 Valproic acid is a teratogen and increases the risk of major congenital malformations.…”

Section: Discussionmentioning

confidence: 63%

Chorea Gravidarum Associated with Poor Perinatal Outcomes: Report of Two Cases

Kütük¹,

Dolanbay²,

Uysal³

et al. 2015

Turkiye Klinikleri J Case Rep

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Section: Discussionmentioning

confidence: 63%

Chorea Gravidarum Associated with Poor Perinatal Outcomes: Report of Two Cases

Kütük¹,

Dolanbay²,

Uysal³

et al. 2015

Turkiye Klinikleri J Case Rep

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“…Carbamazepine and sodium valproate appear to have similar efficacy, 5,6 with carbamazepine being recommended as first line due to a better safety profile. 1 This replaces older recommendations to use haloperidol.…”

Section: Symptomatic Management Of Choreamentioning

confidence: 99%

“…[4][5][6] It is important to be aware of the current evidence Australians. 9 Current estimates for definite and borderline rheumatic heart disease in Australian children range from less than 1 per 1000 population in low-risk children, to 33 per 1000 in parts of the Northern Territory.…”

Section: Introductionmentioning

confidence: 99%

Prescribing for people with acute rheumatic fever

Ralph¹,

Noonan²,

Boardman³

et al. 2017

Aust Prescr

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“…Valproic acid has been recommended as the first-line treatment for SC. [7][8][9] Penicillin should be used for all patients, including those with chorea alone. 10 In the presence of antineuronal antibodies, intravenous immunoglobulin and plasma exchange are thought to be effective.…”

Section: Case Reportmentioning

confidence: 99%

Sydenham's chorea in a family with Huntington's disease: case report and review of the literature

et al. 2011

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CONTEXT: Sydenham's chorea affects almost 30% of patients with acute rheumatic fever. It is more frequent in females and is rare in the first decade of life, and genetic vulnerability underlies it. Because of easy access to antibiotics, it is now rare in so-called developed countries.CASE REPORT: A 6-year-old boy with a family history of Huntington's disease, who was the only child of an unscreened and asymptomatic mother, was brought for a consultation because of migratory arthralgia, depressed mood, and rapid, abrupt and unintentional movements of his right arm and leg, that had evolved over a three-week period. On physical examination, he presented a grade III/VI systolic heart murmur and right-side choreic movements, giving rise to a deficit of active mobilization. Laboratory tests revealed elevated erythrocyte sedimentation rate (63 mm/h), C-reactive protein (25 mg/l) and antistreptolysin O titer (1,824 U/ml). Cardiovascular evaluation showed mild aortic insufficiency, moderate mitral insufficiency and a prolonged PR interval. A clinical diagnosis of Sydenham's chorea/acute rheumatic fever was made, and therapy consisting of penicillin, haloperidol, captopril and furosemide was instituted, with excellent results. CONCLUSION: In developed countries, Sydenham's chorea seems forgotten and, because of this, little is known about its clinical course and controversy surrounds the therapeutic options available. This occurrence of rheumatic chorea in a family with Huntington's disease highlights the importance of the differential diagnosis for the different forms of chorea.ResUMo CONTEXTO: A coreia de Sydenham surge em cerca de 30% dos casos de febre reumática aguda. É mais frequente no sexo feminino, é rara na primeira década de vida e tem por base uma vulnerabilidade genéti-ca. Devido ao fácil acesso aos antibióticos, é uma doença rara atualmente nos países ditos desenvolvidos. RELATO DO CASO: Criança de seis anos, sexo masculino, com história familiar de coreia de Huntington, único filho de mãe assintomática e não rastreada, foi trazido à consulta por artralgias migratórias, humor deprimido e movimentos rápidos, abruptos e não intencionais dos membros superior e inferior direitos, com três semanas de evolução. Ao exame físico, apresentava um sopro cardíaco sistólico grau III/VI, e foram presenciados movimentos coreicos à direita, condicionando um défice de mobilização activa. Os exames laboratoriais mostraram aumento da velocidade de sedimentação (63 mm/h), proteína C-reativa (25 mg/L) e título de antiestreptolisina O (1.824 U/mL). O exame cardiovascular revelou insuficiência aórtica ligeira e insuficiência mitral moderada e aumento do intervalo PR. Foi feito o diagnóstico de coreia de Sydenham/febre reumática aguda, tendo sido instituída terapêutica com penicilina, haloperidol, captopril e furosemida, com excelente resultado. CONCLUSÃO: Nos países desenvolvidos, a coreia de Sydenham parece esquecida e, por isso, pouco se sabe quanto ao seu curso clínico e as opções terapêuticas disponíveis são controver...

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Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens

Cited by 94 publications

References 20 publications

Chorea Gravidarum Associated with Poor Perinatal Outcomes: Report of Two Cases

Chorea Gravidarum Associated with Poor Perinatal Outcomes: Report of Two Cases

Prescribing for people with acute rheumatic fever

Sydenham's chorea in a family with Huntington's disease: case report and review of the literature

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