Sydenham’s Chorea and Psychopathology

Ja, Wilcox; Nasrallah, H.A.

doi:10.1159/000118424

Cited by 19 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one prospective case–control study by Wilcox and Nasrallah, evidence, spanning 10 years, from 29 individuals with Sydenham's chorea and 29 unaffected individuals was examined. The authors reported that individuals in the Sydenham's chorea group were 8.9 times more likely to develop schizophrenia than those in the comparison group.…”

Section: Resultsmentioning

confidence: 99%

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Punukollu

Mushet

Linney³

et al. 2015

Develop Med Child Neuro

View full text Add to dashboard Cite

OCDObsessive-compulsive disorder PANDAS Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections AIM Sydenham's chorea is a post-streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long-term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long-term outcomes for children with Sydenham's chorea.METHOD The study used a systematic search strategy, using MEDLINE, MEDLINE in Process, EMBASE, and The Cochrane Library. Abstracts were screened to identify relevant papers which were then assessed further. Eligible papers were summarized.

show abstract

Section: Resultsmentioning

confidence: 99%

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Punukollu

Mushet

Linney³

et al. 2015

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…The interest in psychoses associated with RF continued throughout the 1900's [187-197]. People with a history of Sydenham chorea and/or rheumatic fever are at high risk for developing psychopathology later in life [198,199] with a relative risk for schizophrenia as high as 8.9 in a 10 year follow-up of 29 Sydenham patients [200]. There is a suggestion that the family members of Sydenham patients are also at higher risk for psychosis [201].…”

Section: Discussionmentioning

confidence: 99%

Theories of schizophrenia: a genetic-inflammatory-vascular synthesis

2005

View full text Add to dashboard Cite

Background: Schizophrenia, a relatively common psychiatric syndrome, affects virtually all brain functions yet has eluded explanation for more than 100 years. Whether by developmental and/or degenerative processes, abnormalities of neurons and their synaptic connections have been the recent focus of attention. However, our inability to fathom the pathophysiology of schizophrenia forces us to challenge our theoretical models and beliefs. A search for a more satisfying model to explain aspects of schizophrenia uncovers clues pointing to genetically mediated CNS microvascular inflammatory disease.

show abstract

“…In other studies, generalized anxiety disorder was found at higher rates in first‐degree relatives of children with a history of rheumatic fever 16 . Psychosis was reported in one case; 17 however, retrospective studies in 369 individuals with psychosis have shown a higher than expected incidence of a history of Sydenham chorea, 18 and a prospective controlled study found that individuals with Sydenham chorea ( n =29) have a significantly higher risk of developing schizophrenia 19 …”

mentioning

confidence: 95%

Cognitive and psychiatric phenotypes of movement disorders in children: a systematic review

Ben‐Pazi

Jaworowski

Shalev

2011

Developmental Medicine &Amp; Child Neurology

View full text Add to dashboard Cite

OCDObsessive-compulsive disorder ODD Oppositional defiant disorder PANDAS Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections RLS Restless legs syndrome AIM The cognitive and psychiatric aspects of adult movement disorders are well established, but specific behavioural profiles for paediatric movement disorders have not been delineated. Knowledge of non-motor phenotypes may guide treatment and determine which symptoms are suggestive of a specific movement disorder and which indicate medication effects.METHOD The goal of this review is to outline the known cognitive and psychiatric symptoms associated with paediatric movement disorders. We used a systematic approach, via PubMed, and reviewed over 400 abstracts of studies of selected disorders, of which 88 papers reporting paediatric non-motor symptoms are summarized.RESULTS Obsessive-compulsive disorder was manifest in children with paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and Sydenham chorea. Children with opsoclonus-myoclonus syndrome had, for the most part, cognitive and behavioural problems, and attention-deficit-hyperactivity disorder was reported as a major comorbidity in Tourette syndrome, stereotypies, and restless legs syndrome. Symptoms of depression and anxiety were more frequent in individuals with idiopathic dystonia. Affective disorders were suggestive of Wilson disease. Cognitive decline was common in children with juvenile Huntington disease. A limitation of this review was the lack of systematic assessment in paediatric movement disorders for evaluation and uniform definitions.

show abstract

Sydenham’s Chorea and Psychopathology

Cited by 19 publications

References 14 publications

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Theories of schizophrenia: a genetic-inflammatory-vascular synthesis

Cognitive and psychiatric phenotypes of movement disorders in children: a systematic review

Contact Info

Product

Resources

About