Sychronous parathyroid carcinoma and multifocial papillary thyroid carcinoma: a case report

Kuzu, Fatih; Cinkaya, Ahmet; Ekici, Mehmet Fati̇h; Kodaz, Hilmi; Deger, Aysenur

doi:10.14744/ejmo.2017.98608

Cited by 3 publications

(3 citation statements)

References 10 publications

(12 reference statements)

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“…Synchronous parathyroid and nonmedullary thyroid carcinomas are extremely rare with only 15 previous cases reported in literature, 1,5–7,13–23 and no correlation, up to date, has been discovered between these entities 24 . Twelve patients (84%) were females with relatively young age (mean age of 56 years).…”

Section: Discussionmentioning

confidence: 96%

Synchronous parathyroid carcinoma and papillary thyroid carcinoma

Naçef

Khelifi

Kalthoum

et al. 2022

Clinical Case Reports

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The simultaneous occurrence of parathyroid carcinoma and nonmedullary thyroid carcinoma is unusual. We report the case of 60‐year‐old woman who was found to have concurrent parathyroid carcinoma with severe clinical manifestations of primary hyperparthyroidism in addition to an incidental papillary thyroid carcinoma. Parathyroid hormone level was 569 pg/ml (normal range 10–65), and the serum calcium concentration was 13.83 mg/dl (normal range, 8.8–10.4). Preoperative investigation found a large 3 cm anterior cervical nodule suggestive of parathyroid adenoma. Total thyroidectomy and left parathyroidectomy were performed, and the final anatomopathological examination of the operative specimen concluded the coexistence of papillary microcarcinoma and parathyroid carcinoma. Although parathyroid carcinoma is an uncommon cause of hypercalcemia, it should be considered when severe hypercalcemia is observed, and in case of coexistence of thyroid nodules. The possibility of both malignancies must also be considered since parathyroid and nonmedullary thyroid carcinoma rare cases have previously been reported.

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Section: Discussionmentioning

confidence: 96%

Synchronous parathyroid carcinoma and papillary thyroid carcinoma

Naçef

Khelifi

Kalthoum

et al. 2022

Clinical Case Reports

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“…e simultaneous presence of thyroid and parathyroid carcinoma is extremely rare with only 15 documented cases [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] in the last 41 years, and no correlation, up to date, has been discovered between these entities [31]. Comparison of the previous cases and ours are described in Table 1.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature

Lam

Rodríguez-Orihuela

González

et al. 2020

Case Reports in Endocrinology

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Synchronous parathyroid and papillary thyroid carcinoma are extremely rare. To our knowledge, only 15 cases have been reported in the last four decades. We describe a 50-year-old female without significant past medical or family history and no previous trauma presented with left heel pain that prompted her to seek medical attention. Physical examination was notable for a painless nodule at the left thyroid lobe. Laboratory evaluation showed a serum calcium level of 14.3 mg/dL (8.6–10.3 mg/dL) and intact parathyroid hormone level of 1160 pg/mL (12–88 pg/mL). 99Tc-sestamibi dual-phase with single-photon emission computed tomography fused images showed increased uptake at the left-sided inferior parathyroid gland. Neck ultrasound showed a 1.4 cm heterogeneous nodule in the middle-third of the left thyroid gland and a solitary 1.9 cm vascularized and hypoechoic oval nodule that was considered likely to represent a parathyroid adenoma. Due to its clinical context (severe hypercalcemia and very high levels of PTH), parathyroid carcinoma (PC) was suspected although imaging studies were not characteristic. The patient underwent en bloc resection of the parathyroid mass and left thyroid lobe and central neck compartment dissection. Pathology analysis revealed classical papillary thyroid carcinoma of classical subtype and parathyroid carcinoma. Immunohistochemical staining was positive for cyclidin D1 and negative for parafibromin. High clinical suspicion is required for parathyroid carcinoma diagnosis in the presence of very high level of parathyroid hormone, marked hypercalcemia, and the existence of any thyroid nodule should be approached and the coexistence of other carcinomas should be considered.

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“…A review of literature demonstrated that at least 23 other cases of synchronous parathyroid carcinoma and non-medullary thyroid carcinoma have been reported 3 11–17. Reported patients have been mostly women (75%) with a mean age of 52 years.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous presentation of parathyroid carcinoma, papillary thyroid cancer and ACTH-independent hypercortisolism due to benign cortical adenoma

et al. 2019

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A 46-year-old woman presented with hypertension and renal disease. Investigations showed severe hypercalcaemia due to primary hyperparathyroidism. Imaging demonstrated renal calculi and an incidental left adrenal lesion. Additional biochemistry confirmed adrenocorticotropic hormone-independent hypercortisolism. Ultrasound and sestamibi scan found an enlarged right-sided parathyroid gland and a suspicious right thyroid nodule, biopsy of which suggested papillary carcinoma. The right parathyroid mass, right thyroid lobe and right central compartment tissue along with a segment of the right recurrent laryngeal nerve was resected en-bloc. Completion thyroidectomy and left adrenalectomy were performed 6 months later. Histology showed parathyroid cancer, multifocal papillary thyroid cancer and adrenal clear cell cortical adenoma. Genetic tests were normal. There was no evidence of recurrence at 12 months follow-up. Parathyroid cancer should be suspected in the presence of significant hypercalcaemia, very high parathyroid hormone and end organ damage. Suspicious thyroid nodules on imaging should be appropriately investigated.

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Sychronous parathyroid carcinoma and multifocial papillary thyroid carcinoma: a case report

Cited by 3 publications

References 10 publications

Synchronous parathyroid carcinoma and papillary thyroid carcinoma

Synchronous parathyroid carcinoma and papillary thyroid carcinoma

An Unusual Simultaneous Existence of Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Case Report and Review of Literature

Simultaneous presentation of parathyroid carcinoma, papillary thyroid cancer and ACTH-independent hypercortisolism due to benign cortical adenoma

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