Abstract:There are limited data on the best approach to managing azole-induced
hepatotoxicity. One described approach is switching between different
triazole agents to prevent the need for intravenous therapy. This case
series describes the outcomes of this approach in seven children. The
most common azole switch was voriconazole to fluconazole (3/7), followed
by fluconazole to voriconazole (2/7). One child each switched from
voriconazole to itraconazole, and posaconazole to fluconazole. Of the
seven cases, five had Gr… Show more
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