Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Han, Qiuju; Wang, Weizhi; Jia, Xiangqian; Qian, Yixia; Li, Qian; Wang, Zihua; Zhang, Weikai; Yang, Shu Hua; Jia, Yunhong; Hu, Zhiyuan

doi:10.1021/acsami.6b05678

Cited by 38 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, efficient accumulation and penetration of PTX in the tumor was observed due to the negative charge of the peptide in the blood circulation and its positive charge at the tumor side. The pH-responsive SKDEEWHKNNFPLSP peptide was investigated by Han et al [134], being an affinity ligand of the angiogenesis marker vascular endothelial growth factor receptor 2 (VEGFR2). Its pH-responsiveness is due to the KDEE-segment at its N-terminus, which forms an α helix in presence of protons.…”

Section: Please Insert Here Figure13mentioning

confidence: 99%

Stimulus-responsive liposomes for biomedical applications

Antoniou

Giofrè

Seneci

et al. 2021

Drug Discovery Today

View full text Add to dashboard Cite

Liposomes are amphipathic lipidic supramolecular aggregates able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems since long due to their favorable features, such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the possibility to introduce chemical modifications on liposomes has paved the way to smart liposome-based drug delivery systems characterized by even more tunable and disease-directed features. In this review, the different types of chemical modifications introduced so far have been highlighted, with a particular focus on internal stimuli-responsive liposomes and pro-drug activation.

show abstract

Section: Please Insert Here Figure13mentioning

confidence: 99%

Stimulus-responsive liposomes for biomedical applications

Antoniou

Giofrè

Seneci

et al. 2021

Drug Discovery Today

View full text Add to dashboard Cite

show abstract

“…By using thin film dispersion method as previously described, [ 22 ] we prepared negatively charged nanoparticles (N‐NP) and positively charged nanoparticles (P‐NP) for comparison. We then constructed a charge‐reversible liposome nanocarrier, O‐NP, consisting of cationic lipid core (P‐NP) modified with OMPE.…”

Section: Resultsmentioning

confidence: 99%

“…OMPE‐modified liposome (O‐NP) was prepared via film dispersion method. [ 22 ] O‐NP was consisted of DOTAP, DOPC, SPC, DSPE‐PEG 2000 , CHO, and OMPE (molecular ratio, 7:32:13:2:13:3) in chloroform/methanol (volume ratio, 3:1). The solvent was removed by vacuum rotary evaporation to form a dry drug‐containing lipid film.…”

Section: Methodsmentioning

confidence: 99%

Matrix Metalloproteinase‐9‐Responsive Surface Charge‐Reversible Nanocarrier to Enhance Endocytosis as Efficient Targeted Delivery System for Cancer Diagnosis and Therapy

Han

Lan

Wen

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

Nanoparticles, that can be enriched in the tumor microenvironment and deliver the payloads into cancer cells, are desirable carriers for theranostic agents in cancer diagnosis and treatment. However, efficient targeted delivery and enhanced endocytosis for probes and drugs in theranostics are still major challenges. Here, a nanoparticle, which is capable of charge reversal from negative to positive in response to matrix metalloproteinase 9 (MMP9) in tumor microenvironment is reported. This nanoparticle is based on a novel charge reversible amphiphilic molecule consisting of hydrophobic oleic acid, MMP9‐cleavable peptide, and glutamate‐rich segment (named as OMPE). The OMPE‐modified cationic liposome forms an intelligent anionic nanohybrid (O‐NP) with enhanced endocytosis through surface charge reversal in response to MMP9 in vitro. Successfully, O‐NP nanohybrid performs preferential accumulation and enhances the endocytosis in MMP9‐expressing xenografted tumors in mouse models, which improve the sensitivity of diagnosis agents and the antitumor effects of drugs in vivo by overcoming their low solubility and/or nonspecific enrichment. These results indicate that O‐NP can be a promising delivery platform for cancer diagnosis and therapy.

show abstract

“…Additionally, a pH-sensitive switchable nanodrug was reported by Hu and coworkers. 77 DOX molecules were encapsulated into liposomes (LS), and the LS were functionalized by a peptide STP (SKDEEWHKNNFPLSP). In the presence of protons within the acidic tumor microenvironment, the segment of KDEE in STP can form an a helix, which could improve the internalization.…”

Section: Phmentioning

confidence: 99%