Switchable Catalysis:  Modular Synthesis of Functionalized Pyrimidinones via Selective Sulfide and Halide Cross-Coupling Chemistry

Abstract

[reaction: see text] A general demonstration of orthogonal selectivity of the Liebeskind-Srogl cross-coupling protocol compared to the Suzuki-Miyaura and Stille variants is reported.

Synthesis and anti‐HIV‐1 and anti‐HCMV Activity of 1‐Substituted 3‐(3,5‐Dimethylbenzyl)uracil Derivatives.

“…It has been reported that methylation of 2-thiouracil gives a 2-methylthio derivative. 19,20) This tendency was also verified in the case of 3-substituted 2,4-dithiouracil 4b. The preference of substitution on the sulphur atom could be explained by strong nucleophilicity of the 2-sulfide anion formed by treatment of 4b with a strong base.…”

Palladium‐Catalyzed Amidation and Amination of 8‐Iodopurine

“…Again, this reaction proceeded equally well with arylamines bearing electron-withdrawing and electron-donating substituents. [40,42,43] Although not optimized, it is reported therein for the first time with a 6-phenylthiopurine heterocycle, expanding the scope of this useful reaction. All these reactions were performed under the conditions of Table 1, Entry 6 with the exception of sulfonamides 7a and 7b, for which the reaction was carried out at 100°C overnight.…”

New strategy for the synthesis of Bromacil and their analogous

“…Furthermore, 5-halouracilas can be used as synthetic intermediates in coupling reactions. 5 In this work we present the synthesis of 5-bromo uracils (14-17), the Bromacil analogous, through a methodology quickly and efficiently.…”