Abstract:Background: Accurate quantitation of plasma Human immunodeficiency virus-1 (HIV) RNA levels is required for clinical management of HIV-1-infected patients. Several assays are used to quantify HIV RNA, and prior to implementing a change in viral load method, continuity in reported values is addressed by the laboratory and communicated to clinicians. Methods: We initially compared COBAS ® AmpliPrep-COBAS ® TaqMan 48 (TaqMan) v.1.0 (Roche) to prior methodology, branched-chain DNA (bDNA) v.3.0 (Siemens) to determi… Show more
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