Swiss Feline Cancer Registry 1965–2008: the Influence of Sex, Breed and Age on Tumour Types and Tumour Locations

Graf, Ricarda; Grüntzig, Katrin; Boo, Gianluca; Hässig, Michael; Axhausen, Kay W.; Fabrikant, Sara Irina; Welle, Molly; Meier, Dorette; Guscetti, Franco; Folkers, Gerd; Otto, Vivianne I.; Pospischil, Andreas

doi:10.1016/j.jcpa.2016.01.008

Cited by 39 publications

(67 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, the 10 most common skin tumours accounted for 80.7% of all cutaneous neoplasms, despite the large number of different diagnoses given for masses arising at this site (89 in total). Both in this study and in three other large studies 2,3,4 looking at the prevalence of different skin tumours in cats, the four most commonly diagnosed tumours are very consistent, despite the differences in geographical location and time periods covered by the studies. These four skin tumours are basal cell tumours, MCTs, fibrosarcomas and SCCs, although the precise order of prevalence varies depending on the particular study.…”

Section: Discussionsupporting

confidence: 80%

“…There is some variation between these studies, but the general consensus is that the four most common skin tumour types are fibrosarcoma, squamous cell carcinoma (SCC), mast cell tumour (MCT) and the tumours that fall under the umbrella term of 'basal cell tumour', [2][3][4][5] with some differences in the order of prevalence depending on the particular study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Retrospective study of more than 9000 feline cutaneous tumours in the UK: 2006–2013

Smith

Dobromylskyj³

2017

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives The aim of the study was to utilise a large database available from a UK-based, commercial veterinary diagnostic laboratory to ascertain the prevalence of different forms of cutaneous neoplasia within the feline population, and to detect any breed, sex or age predilections for the more common tumours. Methods Records from the laboratory were searched for feline submissions received between 31 May 2006 and 31 October 2013. For masses arising within the skin for which histopathology had been performed, the diagnosis was recorded together with the breed, age, sex and neuter status of the cat. Odds ratios for breed predisposition to skin tumours overall, to histologically malignant tumours and to the more commonly occurring tumours were calculated, with the non-pedigree cat population as the control. Results Of the 219,083 feline samples submitted, masses arising within the skin comprised 4.4% and there were 89 different diagnoses recorded for these masses. Just 6.6% of these cases were non-neoplastic in nature, and, of neoplastic masses, 52.7% were considered histologically malignant. The 10 most common skin tumour types accounted for 80.7% of cases, with the four most common being basal cell tumours, fibrosarcomas, squamous cell carcinomas and mast cell tumours. Conclusions and relevance Despite the large number of different diagnoses in this study, a relatively small number of tumour types accounts for the majority of skin masses occurring in cats, most of which are neoplastic in nature. There are a number of breed predispositions for the more common tumour types, although no pedigree breed had increased odds of developing a malignant tumour compared with the non-pedigree cat population; several breeds had significantly decreased odds. Just over half of the neoplastic masses in this study were considered histologically malignant.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Retrospective study of more than 9000 feline cutaneous tumours in the UK: 2006–2013

Smith

Dobromylskyj³

2017

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…Population‐based data describing epidemiology of feline neoplasia are scant. Direct comparison with our findings is problematic due to diverse study populations, disparate inclusion criteria, and dissimilar methods for disease estimation . Lymphoma is the most commonly reported feline neoplasm and most prevalent form of gastrointestinal cancer .…”

Section: Discussionmentioning

confidence: 78%

Long‐term incidence and risk of noncardiovascular and all‐cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Fox

Keene

Lamb³

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundEpidemiologic knowledge regarding noncardiovascular and all‐cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence‐based healthcare guidelines.ObjectivesTo characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all‐cause mortality in AH and pHCM cats.AnimalsA total of 1730 client‐owned cats (722 AH, 1008 pHCM) from 21 countries.MethodsRetrospective, multicenter, longitudinal, cohort study. Long‐term health data were extracted by medical record review and owner/referring veterinarian interviews.ResultsNoncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P = .48). Cancer, chronic kidney disease, and conditions characterized by chronic weight‐loss‐vomiting‐diarrhea‐anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All‐cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P < .001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P = .10), but all‐cause survival was significantly shorter in pHCM (P = .0001).Conclusions and Clinical ImportanceAll‐cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.

show abstract

“…The objectives of this part 2 were (1) to apply the histological staging system introduced in dogs (Part 1) to FMCs, and (2) to validate its prognostic value in terms of patient outcomes (disease-free interval, overall survival, and specific survival).…”

Section: Introductionmentioning

confidence: 99%

Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 2: Feline Mammary Carcinomas

et al. 2019

View full text Add to dashboard Cite

Background: Feline mammary carcinomas (FMCs) are characterized by a high frequency of metastatic spread. The clinical TNM (Tumor, Node, Metastasis) system is used to describe local, regional, and distant tumor extent within the patient, but few publications confirmed its association with survival in cats with FMC. The purpose of this study was to determine if the histological staging system proposed for dogs in part 1 of this article had significant association with prognosis in cats.Materials and Methods: This retrospective study included 395 female cats with a surgically removed mammary carcinoma, with a 2-year follow-up. Invasiveness (distinction between in situ and invasive FMCs), the pathologic tumor size (pT), lymphovascular invasion (LVI), and the pathologic nodal stage (pN) defined a 5-stage system: Stage 0 (FMCs in situ), Stage I (pT1, LVI–, pN0–pNX), Stage II (pT2, LVI–, pN0–pNX), Stage IIIA (pT1, LVI+ and/or pN+), and Stage IIIB (pT2, LVI+ and/or pN+), where pT1 was ≤20 mm, pT2 was >20 mm, and pNX corresponded to unsampled draining lymph node.Results: Higher histological stages were associated with reduced disease-free interval, overall survival, and specific survival. For cancer-specific survival, by univariate analysis (p < 0.0001), median survival times and 1-year specific survival rates (1ySSR) were: stage 0 (1484 days; 1ySSR = 85%; N = 55; 14% of the cats), stage I (808 days; 1ySSR = 76%; N = 103; 26%), stage II (377 days; 1ySSR = 51%; N = 56; 14%), stage IIIA (448 days; 1ySSR = 60%; N = 83; 21%), and stage IIIB (207 days; 1ySSR = 29%; N = 98; 25%). The histological stages were also associated with specific survival by multivariate analysis (Hazard Ratio (HR) = 2.72 for stage IIIB, HR = 1.76 for stage IIIA, HR = 1.50 for stage II compared with stage I), independently of Progesterone Receptor expression (HR = 0.34 for PR+ compared with PR– FMCs) and tumor-associated inflammation (HR = 1.33 when moderate to severe compared with absent to mild).Conclusion: A same histological staging system could be applied in dogs and cats with mammary carcinoma to refine prognosis assessment. In the near future, a preoperative complete tumor clinical staging and treatment based on the published standard of care should be performed in order to better validate the histological staging system here proposed.

show abstract

Swiss Feline Cancer Registry 1965–2008: the Influence of Sex, Breed and Age on Tumour Types and Tumour Locations

Cited by 39 publications

References 26 publications

Retrospective study of more than 9000 feline cutaneous tumours in the UK: 2006–2013

Retrospective study of more than 9000 feline cutaneous tumours in the UK: 2006–2013

Long‐term incidence and risk of noncardiovascular and all‐cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 2: Feline Mammary Carcinomas

Contact Info

Product

Resources

About