SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development

Vasiliauskas, Daniel; Hancock, Sarah; Stern, Claudio D.

doi:10.1016/s0925-4773(99)00014-3

Cited by 52 publications

(49 citation statements)

References 109 publications

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“…On 17q, the RefSeq gene WSB1 lies within 96 kb of monomeric ␣-satellite. WSB1 is also expressed in the brain and contains several WD repeats as well as a SOCS-box (Vasiliauskas et al 1999). The genomic region between the functional centromere and the ␣-satellite junction (the " pericentromere"), therefore, is a complex region, containing blocks of monomeric ␣-satellite, other satellites, and at least some expressed sequences.…”

Section: Resultsmentioning

confidence: 99%

The evolutionary dynamics of α-satellite

Rudd¹,

Wray²,

Willard³

2005

Genome Res.

125

144

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␣-Satellite is a family of tandemly repeated sequences found at all normal human centromeres. In addition to its significance for understanding centromere function, ␣-satellite is also a model for concerted evolution, as ␣-satellite repeats are more similar within a species than between species. There are two types of ␣-satellite in the human genome; while both are made up of ∼171-bp monomers, they can be distinguished by whether monomers are arranged in extremely homogeneous higher-order, multimeric repeat units or exist as more divergent monomeric ␣-satellite that lacks any multimeric periodicity. In this study, as a model to examine the genomic and evolutionary relationships between these two types, we have focused on the chromosome 17 centromeric region that has reached both higher-order and monomeric ␣-satellite in the human genome assembly. Monomeric and higher-order ␣-satellites on chromosome 17 are phylogenetically distinct, consistent with a model in which higher-order evolved independently of monomeric ␣-satellite. Comparative analysis between human chromosome 17 and the orthologous chimpanzee chromosome indicates that monomeric ␣-satellite is evolving at approximately the same rate as the adjacent non-␣-satellite DNA. However, higher-order ␣-satellite is less conserved, suggesting different evolutionary rates for the two types of ␣-satellite.[Supplemental material is available online at www.genome.org.]All ␣-satellite DNA is made up of tandem monomers, each ∼171 bp in length (Manuelidis and Wu 1978;Willard and Waye 1987b). As revealed by patterns of monomer organization, there are two major types of ␣-satellite DNA in the human genome, designated higher-order and monomeric (Warburton and Willard 1996;Alexandrov et al. 2001;. Higher-order ␣-satellite DNA is made up of monomers arranged in multimeric repeat units that are highly similar from repeat unit to repeat unit. These higher-order repeat units are positioned tandemly to make up an array of extremely homogeneous higher-order ␣-satellite typically several megabases in size. In contrast, monomeric ␣-satellite lacks detectable higher-order periodicity, and its constituent monomers are far less homogeneous than are higher-order repeat units . All normal human centromeres contain large arrays of higher-order ␣-satellite (Warburton and Willard 1996;Alexandrov et al. 2001), and, where investigated, these arrays have been found to be bordered by more heterogeneous monomeric ␣-satellite (Wevrick et al. 1992;Horvath et al. 2000;Schueler et al. 2001;Guy et al. 2003;. The adjacent organization of higherorder and monomeric ␣-satellite, as well as the fact that lower primates have only monomeric ␣-satellite at their centromeres (Rosenberg et al. 1978;Musich et al. 1980;Maio et al. 1981;Thayer et al. 1981;Alves et al. 1994), has led to the hypothesis that higher-order ␣-satellite evolved from ancestral arrays of monomeric ␣-satellite and subsequently transposed to the centromeric regions of all great ape chromosomes (Warburton and Willard 1996;Alexandrov et al. ...

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Section: Resultsmentioning

confidence: 99%

The evolutionary dynamics of α-satellite

Rudd¹,

Wray²,

Willard³

2005

Genome Res.

125

144

View full text Add to dashboard Cite

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“…Like patched, Hip is transcriptionally activated by hedgehog signalling, and it has also been proposed to be a negative regulator of signalling (Chuang and McMahon, 1999). Another gene shown to be responsive to hedgehog signalling in both the somites and limb buds is a member of a novel family of SOCS (suppressor of cytokine signalling) box-containing WDproteins and has been termed both WSB1 and SWIP-1 (Hilton et al, 1998;Vasiliauskas et al, 1999). This gene is one of the earliest markers to respond to sonic hedgehog in the limb, but its role in the signalling pathway remains unclear (Vasiliauskas et al, 1999).…”

Section: Downstream Targets Of Hedgehog Signallingmentioning

confidence: 99%

The hedgehog signalling pathway in tumorigenesis and development

1999

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“…To date only a small number of target genes have been described in vertebrate tissues. These include HNF-3b (Roelink et al, 1995) and COUP-TFII (Krishnan et al, 1997) in the developing neural tube, SWiP-1 (Vasiliauskas et al, 1999) and SFRP-2 in somitic mesoderm, and angiopoietin2 in developing vasculature (Pola et al, 2001). Other tissuespecific targets include members of the BMP (Bitgood and McMahon, 1995), PAX (Ericson et al, 1996), SOX (Hargrave et al, 2000) and TBX (Gibson-Brown et al, 1998;Garg et al, 2001) families.…”

Section: Introductionmentioning

confidence: 99%