Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats

Cardoso, Andréia Machado; Abdalla, Fátima Husein; Bagatini, Margarete Dulce; Martins, Cibele Chalita; Fiorin, Fernando da Silva; Baldissarelli, Jucimara; Costa, Pauline da; Mello, Fábio Fernandes; Fiorenza, Amanda Maino; Serres, Jonas Daci da Silva; Gonçalves, Jamile Fabbrin; Chaves, Heloísa; Royes, Luiz Fernando Freire; Belló‐Klein, Adriane; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina

doi:10.1093/ajh/hpt030

Cited by 33 publications

(31 citation statements)

References 32 publications

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“…This result is in agreement with previously described studied by Balbinott et al (2005). Also, many authors have reported the ability of the arginine analog, L-NAME, to induce systemic arterial hypertension (Furstenau et al, 2008(Furstenau et al, , 2010Cardoso et al, 2012Cardoso et al, , 2014, which probably occurs due to the capacity of L-NAME to inhibit the production of nitric oxide, a well known vasodilator molecule, by blocking nitric oxide synthase (NOS) activity (Moncada et al, 1991). However, dietary supplementation with both rhizomes and treatment with a positive control drug (atenolol) caused a significant reduction of SBP in the hypertensive rats (Fig.…”

Section: Mol Ache/h/mg Proteinsupporting

confidence: 90%

“…The chronic inhibition of NO produces volumedependent elevation of blood pressure and its physiological and pathological characteristics resemble essential hypertension (Lerman et al, 2005;Cardoso et al, 2012Cardoso et al, , 2014. Several studies have administered in vivo an inhibitor of nitric oxide biosynthesis, the N-nitro-L-arginine methyl ester hydrochloride (L-NAME), which is an L-arginine analog, to induce hypertension in rats (Furstenau et al, 2008(Furstenau et al, , 2010Cardoso et al, 2012Cardoso et al, , 2014. The brain especially the cerebral cortex is a major target of the deleterious effects of hypertension and is responsible for a large portion of the related mortality and morbidity (Dahlof, 2007;Toth et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The acetylcholinesterase (AChE) enzyme is responsible for the degradation of ACh in the synaptic cleft of cholinergic synapses and neuromuscular junctions into inactive metabolites such as choline and acetate (Lendvai and Vizi, 2008). This enzyme has essential role in regulating many vital functions such as learning, memory, cortical organization of movement and cerebral blood flow control which demonstrates the high degree of importance of ACh as a neurotransmitter target for the study of cerebrovascular diseases associated with hypertension (Lendvai and Vizi, 2008;Cardoso et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…# adenosine, they could constitute a considerable point of regulation in the regulation of blood flow in hypertension (Schetinger et al, 2007;Lunkes et al, 2009;Cardoso et al, 2014). New research directions in the last decade have led to major developments in the uses of plant in bioscience and biomedicine (Quave et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats

Akinyemi¹,

Thomé²,

Morsch³

et al. 2016

JAB

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Ectonucleotidase ADA Acetylcholinesterase a b s t r a c t Ginger and turmeric rhizomes are used in folk medicine for the treatment of several cerebrovascular diseases with limited scientific basis for their action. Hence, in this study, we investigate the effects of two Zingiberaceae varieties (ginger and turmeric) on ectonucleotidases (NTPDase and 5 0 -nucleotidase), adenosine deaminase (ADA) and acetylcholinesterase (AChE) activities in synaptosomes of cerebral cortex from L-NAME induced hypertensive rats. The animals were divided into seven groups (n = 10): normotensive control rats; hypertensive rats; hypertensive rats treated with atenolol; normotensive and hypertensive rats treated with 4% supplementation of turmeric and ginger rhizomes, respectively. After 14 days of pre-treatment with both rhizomes the animals were induced with hypertension by oral administration of L-NAME. The results revealed an increase of ATP and AMP hydrolysis as well as ADA and AChE activities of cerebral cortex synaptosomes in induced rats when compared with the control. The supplementation of both rhizomes prevented these alterations by decreasing ATP and AMP hydrolysis and ADA and AChE activities in cerebral cortex. In conclusion, this study demonstrated that both rhizomes Please cite this article in press as: Akinyemi, A.J., et al., Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats.

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Section: Mol Ache/h/mg Proteinsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats

Akinyemi¹,

Thomé²,

Morsch³

et al. 2016

JAB

View full text Add to dashboard Cite

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“…Therefore, it was suggested that exercise training caused temporary increases in the memory of rats (32). The mechanism that explains the enhancement of cognitive performance with regular exercise was studied by several authors who published that exercise training was able to suppress cholinesterase activity in various brain regions such as the cerebral cortex, hypothalamus and hippocampus (33). Another mechanism may be the decrease of oxidative stress in brain protein (9).…”

Section: Discussionmentioning

confidence: 99%

Impact of Exercise and Vitamin B<sub>1</sub> Intake on Hippocampal Brain-Derived Neurotrophic Factor and Spatial Memory Performance in a Rat Model of Stress

Dief

Samy

Dowedar

2015

J Nutr Sci Vitaminol

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Summary Chronic stress affects brain areas involved in learning and emotional responses through modulation of neurotropic factors or neurotransmitters. Therefore, we investigated the role of exercise and thiamine supplementation on spatial memory and on brain-derived neurotrophic factor (BDNF) and acetylcholine (Ach) content in the hippocampus of the stressed animals. Male Wistar rats were randomly assigned to 4 groups (8 rats/group): control group; stress group; swimming and stress group; and thiamine and stress group. All animals were assessed by a T maze for spatial memory or open fi eld test for locomotion and anxiety. BDNF and Ach were estimated in the hippocampus. Chronic immobilization stress resulted in a signifi cant decrease in BDNF and Ach levels in the hippocampus and impairment in spatial memory functions and decreased basal activity. However, either swimming training or thiamine intake for 30 d was proved to induce a signifi cant increase both in BDNF and Ach in conjunction with improved performance in the T maze, marked anxiolytic effect and enhanced ambulation in the open fi eld test, as compared to the stress group. Interestingly, swimming-exercised rats showed signifi cantly higher levels of BDNF versus thiaminereceiving rats, while thiamine-receiving rats showed higher locomotor activity and less freezing behavior in the open fi eld test compared to the swimming group. It was concluded that decreased BDNF and Ach after stress exposure could be a mechanism for the deleterious actions of stress on memory function; swimming exercise or vitamin B 1 supplementation for 30 d was a protective tool to improve coping with chronic stress by modulating BDNF and Ach content along with enhancement of memory functions and motor activities.

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Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

et al. 2016

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Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger (Zingiber officinale) and turmeric (Curcuma longa) with limited scientific basis. Hence, this study assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and adenosine deaminase (ADA) activities in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertensive rats. Animals were divided into seven groups (n = 10): normotensive control rats; induced (l-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively. After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of l-NAME (40 mg/kg/day). The results revealed a significant (p < 0.05) increase in platelet ADA activity and ATP hydrolysis with a concomitant decrease in ADP and AMP hydrolysis of l-NAME hypertensive rats when compared with the control. However, dietary supplementation with turmeric or ginger efficiently prevented these alterations by modulating the hydrolysis of ATP, ADP and AMP with a concomitant decrease in ADA activity. Thus, these activities could suggest some possible mechanism of the rhizomes against hypertension-derived complications associated to platelet hyperactivity. Copyright © 2016 John Wiley & Sons, Ltd.

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Swimming Training Prevents Alterations in Acetylcholinesterase and Butyrylcholinesterase Activities in Hypertensive Rats

Abstract: Exercise training was shown to prevent increased cholinesterase related to inflammatory processes in hypertensive rats, providing a new insight about protective exercise mechanisms to avoid hypertension-related inflammation.

Cited by 33 publications

References 32 publications

Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats

Effect of dietary supplementation of ginger and turmeric rhizomes on ectonucleotidases, adenosine deaminase and acetylcholinesterase activities in synaptosomes from the cerebral cortex of hypertensive rats

Impact of Exercise and Vitamin B<sub>1</sub> Intake on Hippocampal Brain-Derived Neurotrophic Factor and Spatial Memory Performance in a Rat Model of Stress

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

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