Swimming Through Science: Unveiling the Secrets of Endocrine Disruptors with Zebrafish Models

Abstract

The utilization of zebrafish (Danio rerio) as a model organism in studying endocrine disruptor chemicals (EDCs) has emerged as a powerful and versatile approach in toxicology research. This review highlights the numerous advantages that make zebrafish an ideal model for assessing the impact of EDCs on endocrine systems. Zebrafish, with their high fecundity, transparent embryos and rapid development, offer a cost-effective and time-efficient platform for observing the effects of EDC exposure on various endocrine-related pathways. Furthermore, the zebrafish’s amenability to genetic manipulation has revolutionized the study of EDCs, allowing for precise control and modification of specific genes associated with endocrine function. Genetic application, such as transgenesis and CRISPR/Cas9 technology, enable researchers to create targeted mutants, providing valuable insights into the molecular mechanisms underlying endocrine disruption. This review underscores the pivotal role of zebrafish in advancing our understanding of EDCs, emphasizing the synergy between its inherent advantages and genetic tools, thus positioning it as a premier model for unraveling the complexities of endocrine disruption and facilitating the development of targeted interventions