Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice

Sun, Lihua; Wang, Gaohua; Wu, Zuotian; Xie, Yumeng; Zhou, Lin; Xiao, Ling; Wang, Huiling

doi:10.1016/j.pbb.2021.173285

Cited by 9 publications

(5 citation statements)

References 91 publications

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“…[ 24 ] Swimming can promote the neural protection and plasticity mediated by microtubule dynamics in mice with intracerebral hemorrhage. [ 25 ] Yao Hongen, et al [ 26 ] (2005) found that regular swimming is an appropriate exercise method that can improve the functional state of the whole body and increase the functional activity of the central nervous system after 2 weeks of basic swimming training for 9 rats. The mechanism of regular swimming to promote the establishment of animal operant conditioning may be achieved by improving the glutamate transmitter and GABA transmitter in the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Neuromechanism, recovery effect and case study of swimming training intervention in children with cerebral palsy: A case report

Zeng,

Hao,

Wang

et al. 2023

Medicine

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Background: Cerebral palsy, hereinafter referred to as “cerebral palsy”, refers to a non progressive injury that occurs during the development of brain tissue in fetuses or infants. The patients often have walking dysfunction, abnormal balance ability and abnormal body stability, which are mainly caused by Cranial nerves injury. Patient concerns: One child diagnosed with ataxia cerebral palsy by the hospital was recruited, aged 6 years and 9 months. The symptoms were: lower limb adduction and internal rotation, left neck tilt to the left due to insufficient muscle tension, and eyes squint to the right. The movement is clumsy and the coordination ability of limbs is poor; Its body balance function is poor, the sitting and standing position cannot keep the body upright and balanced for a long time, and the coordination of the random movement of hands and eyes is poor; Weak spatial cognition and orientation ability; Have persistent central motor dysfunction. When walking, the body leans forward and sideways, and the gait is staggered, which is easy to fall; In terms of expression, it shows vague language and unclear speech; Relatively retarded in intelligence. Diagnosis and intervention: The study used swimming training intervention to report a twelve months training intervention program for a child with ataxic cerebral palsy, and evaluated it with Berg balance scale and modified Ashworth scale. Outcomes: Swimming training has a significant effect on the rehabilitation of children with ataxic cerebral palsy; The forces from different directions in the water can improve the balance of children with cerebral palsy; Muscle endurance training with medium load intensity can help restore unilateral muscle tension deficiency to a certain extent, and make bilateral muscle tension gradually becomes. consistent, thus enhancing the balance ability, gait and body stability of children with cerebral palsy.

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Section: Discussionmentioning

confidence: 99%

Neuromechanism, recovery effect and case study of swimming training intervention in children with cerebral palsy: A case report

Zeng,

Hao,

Wang

et al. 2023

Medicine

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“…In a recent study by Sun et al (2021) [ 58 ], swimming exercise reduced the vulnerability of mice to CUMS (chronic unpredictable mild stress) and contributed to the AKT/GSK-3β/CRMP2 pathway and microtubule dynamics (assessed by measurement of Tyr-tubulin expression in the hippocampus) mediated protective effects on neuroplasticity. Five weeks of swimming exercise also prevented mice from engaging in the depression-like behaviour induced by CUMS.…”

Section: Discussionmentioning

confidence: 99%

“…Five weeks of swimming exercise also prevented mice from engaging in the depression-like behaviour induced by CUMS. The authors concluded that exercise contributes to stress resilience via the AKT/GSK-3β/CRMP2 pathway and by maintaining microtubule dynamics [ 58 ]. On the other hand, six weeks of endurance exercise provided stress resilience to the morphological changes (dendritic length, dendrite spine density) induced by a later exposure to PSS (predator scent stress).…”

Section: Discussionmentioning

confidence: 99%

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Nowacka-Chmielewska¹,

Grabowska

Grabowski

et al. 2022

IJMS

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Chronic stress, even stress of a moderate intensity related to daily life, is widely acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases. There is a clear relationship between disturbances induced by stressful stimuli, especially long-lasting stimuli, and cognitive deficits in rodent models of affective disorders. Regular physical activity has a positive effect on the central nervous system (CNS) functions, contributes to an improvement in mood and of cognitive abilities (including memory and learning), and is correlated with an increase in the expression of the neurotrophic factors and markers of synaptic plasticity as well as a reduction in the inflammatory factors. Studies published so far show that the energy challenge caused by physical exercise can affect the CNS by improving cellular bioenergetics, stimulating the processes responsible for the removal of damaged organelles and molecules, and attenuating inflammation processes. Regular physical activity brings another important benefit: increased stress robustness. The evidence from animal studies is that a sedentary lifestyle is associated with stress vulnerability, whereas a physically active lifestyle is associated with stress resilience. Here, we have performed a comprehensive PubMed Search Strategy for accomplishing an exhaustive literature review. In this review, we discuss the findings from experimental studies on the molecular and neurobiological mechanisms underlying the impact of exercise on brain resilience. A thorough understanding of the mechanisms underlying the neuroprotective potential of preconditioning exercise and of the role of exercise in stress resilience, among other things, may open further options for prevention and therapy in the treatment of CNS diseases.

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“…CRMP2 is also related to the mechanism of the repair and regeneration of adult brain neurons [ 37 ]. Many previous studies found that in mice with depressive-like behaviors induced by chronic stress, the expression of CRMP2 was significantly decreased, and the neuroplasticity in the hippocampus showed significant injury [ 10 , 38 ]; however, the neuroplasticity in the hippocampus was enhanced after some measures that can improve or prevent depressive-like behaviors were taken [ 39 , 40 , 41 ]. In this study, we found that there was a significant down-regulation of CRMP2 and α-tubulin in the hippocampus of psoriasis-like mice without maternal separation, which represented damage to the neuroplasticity in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

Zhou

et al. 2022

Brain Sciences

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Background: Psoriasis is a common chronic inflammatory skin disease that often causes depression. Early life experience affects brain development and relates to depression. Whether the effect of different MS protocols in early life on anxiety-like and depressive-like behaviors in female offspring with imiquimod (IMQ)-induced psoriasis is unknown. Methods: C57BL/6J mice were subjected to no separation (NMS), brief MS (15 min/day, MS15) or long MS (180 min/day, MS180) from postpartum days (PPD) 1 to PPD21. Then, 5% imiquimod cream was applied for 8 days in adults. Behavioral tests, skin lesions and hippocampal protein expression were also assessed. Results: We found significant psoriasis-like skin lesions in female mice following IMQ application, and mice showed anxiety-like and depressive-like behaviors. Further, increased microglial activation and decreased expression of neuroplasticity were detected in mice following IMQ application. However, after MS15 in early life, mice showed decreased anxiety-like and depressive-like behaviors, indicating resilience. Further, inhibited hippocampal neuroinflammation and increased neuroplasticity were detected. Conclusions: Collectively, this study confirms that brief MS confers resilience to the behavior deficits in female offspring with IMQ-induced psoriasis and reverses the activation of neuroinflammation and the damage of neuroplasticity injury.

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Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3β/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice

Cited by 9 publications

References 91 publications

Neuromechanism, recovery effect and case study of swimming training intervention in children with cerebral palsy: A case report

Neuromechanism, recovery effect and case study of swimming training intervention in children with cerebral palsy: A case report

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis

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