Swim Training Reduces Metformin Levels in Fructose-Induced Insulin Resistant Rats

Abstract

Purpose: Regular exercise training and metformin medication are widely considered to increase insulin sensitivity and protect against type 2 diabetes, however, evaluating the effect of exercise training on the disposition and pharmacokinetics of metformin is unclear. Methods: We investigated the effect of a 4-wk swim training program (45 min/day, 5 days/wk) on the pharmacokinetics for the use of metformin in fructose-induced insulin resistant rats. Fructose-induced insulin resistant rats were assigned into two groups (n=6/group): swim training with metformin (SM), and non-swim training with metformin (CM). Blood samples were collected from 12 h-fasted rats at baseline and at 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, and 12 h after an oral glucose tolerance test (OGTT) with administration of a single dose of metformin (450 mg/kg). Results: Our study revealed that both glucose and insulin levels in the SM group were significantly lower than those in the CM group at 15 min following OGTT. The maximum concentration (Cmax) and area under the serum concentration-time curve (AUC) for the SM group were significantly lower than CM group. The apparent distribution volume (Vd) and the time-averaged total body clearance (CL) for the SM group were significantly higher than those for the CM group. There were no significant differences in the time to maximum concentration (Tmax) or the time to half-life concentration (t1/2) between the two groups. Conclusions: Our data demonstrate that swim training reduces metformin serum levels. 
 
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Metformin improves performance in high‐intensity exercise, but not anaerobic capacity in healthy male subjects

“…26 In the present study, subjects were given a 500 mg metformin capsule to ingest 1 h before the supramaximal test. Subjects in the placebo group were given an empty capsule (same colour and size as the metformin capsule) to ingest 1 h before the test.…”

PENGARUH PEMBERIAN KOMBINASI EKSTRAK DAUN PEPAYA(Carica papaya L.) DAN AKTIVITAS FISIK TERHADAP KADAR GLUKOSA DARAH MENCIT DIABETES MELITUS TIPE II

“…Aktivitas fisik dapat menghasilkan profil glukosa dan lipid yang lebih rendah serta menurunan komplikasi kardiovaskular. Pada orang dengan pra-diabetes dapat mencegah atau menunda perkembangan diabetes mellitus (DM) tipe II (Chien et al, 2012). Kegiatan olahraga berenang, aerobik, jalan kaki dan bersepeda yang dilakukan secara rutin selama kurang lebih 30 menit dapat menurunkan resiko diabetes (PERKENI, 2015).…”

Efeitos de dois protocolos de adaptação ao meio líquido com intensidades diferentes sobre os parâmetros fisiológicos, de desempenho e padrão de nado de ratos Wistar

“…Com relação à duração dos procedimentos de adaptação ao meio líquido, os estudos sugerem protocolos que variam entre duas sessões (Chen et al, 2011;Fujimoto et al, 2011;Higashida et al, 2011;Matsakas et al, 2006), três sessões (De Araujo et al, 2007;Rogatto et al, 2004), cinco sessões (Souza et al, 2010;Gobatto et al, 2001), uma semana (Luiz et al, 2013;Chien et al, 2012;Nounou et al, 2012), dez sessões (De Araujo et al, 2012) e duas semanas Chimin et al, 2009;D`Ávila et al, 2008;De Araujo et al, 2007;Manchado et al, 2006, Voltarelli et al, 2002, com maior frequência de relatos para adaptações mais longas quando considerados dias subsequentes de exposição ao meio líquido (De Araujo et al, 2010;Contarteze et al, 2007;Manchado et al, 2006;Voltarelli et al, 2004) e tempos de estímulo reduzidos, variando entre 5 e 30 minutos Souza et al, 2010;Manchado et al, 2006). Também é possível identificar na literatura, pesquisas que adotam o termo "adaptação" como sinônimo de treinamento físico e não com a interface relacionada à adaptação ao meio líquido.…”