Swim stress reduces chronic pain in mice through an opioid mechanism

Carmody, John; Cooper, K. E.

doi:10.1016/0304-3940(87)90324-7

Cited by 38 publications

(20 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One way opioids may be related to the hedonics of physical activity and participation in MVPA is by reducing the pain that typically occurs during exercise [57][58][59][60][61]. Peripheral endogenous opioids may also help to maintain blood glucose concentrations [62][63][64] and muscle contractile function during vigorous exercise [65], which would also help to reduce muscular discomfort.…”

Section: Discussionmentioning

confidence: 99%

Association of liking and reinforcing value with children's physical activity

Roemmich

Barkley

Lobarinas

et al. 2008

Physiology & Behavior

View full text Add to dashboard Cite

Roemmich, J.N., J.E. Barkley, L.H. Epstein, C.L. Lobarinas, J.H. Foster, and T.M. White: Association of Liking and Reinforcing Value with Children's Physical Activity. Physiol Behav 00 (0) 000-000, 2007 -This study determined whether liking and relative reinforcing value (RRV) of physical activity were associated with time youth spend in moderate-to-vigorous physical activity (MVPA). Boys (n = 21) and girls (n = 15) age 8 to 12 years were measured for height, weight, aerobic fitness, liking and RRV of physical activity, and minutes in MVPA using accelerometers. Independence of liking and RRV of physical activity was established by a low correlation (r = 0.08, p = 0.64). Using MVPA as the dependent variable and hierarchical regression to control for individual differences in age, aerobic fitness, and time the accelerometer was worn in step 1 (R 2 of 0.60 for step 1), addition of liking and RRV of physical activity in step 2 produced an incremental increase in R 2 of 0.12 (p < 0.01). When using median splits of the RRV and liking data to form subject groups, children with both a high liking and RRV of physical activity participated in greater (p ≤ 0.02) MVPA (1340 ± 70 min/week) than children with high RRV-low liking (1040 ± 95 min/week), low RRVhigh liking (978 ± 88 min/week), or low RRV-low liking (1007 ± 68 min/week) of physical activity. Thus, liking and RRV of physical activity are independently associated with MVPA. The combination of a high reinforcing value and liking of physical activity is associated with 33% greater participation in MVPA.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of liking and reinforcing value with children's physical activity

Roemmich

Barkley

Lobarinas

et al. 2008

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…Although we did not measure endorphin levels, the running distances in our experiment were similar to those exhibited by rats in which elevated hendorphin levels were found [68]; comparable data are not available for mice. Therefore, it is possible that the opioid antagonists reversed a reduction in pain perception during exercise [3,15,18], which resulted in reduced wheel running because running became painful. Furthermore, the opioid antagonists might have reduced wheel running by blocking endorphin-mediated glucose uptake [69], or by blocking endorphin-mediated delay of fatigue [70].…”

Section: Discussionmentioning

confidence: 99%

“…For example, following a forced swimming protocol, responsiveness to nociceptive stimuli (e.g., heat applied to the tail or feet, electrical stimuli to the feet) decreases in both rats [12,13] and mice [14][15][16][17][18]. In these cases, though, whether the decreased pain perception is caused by the physical activity, the stressful nature of forced swimming itself, or changes in body temperature with swimming is difficult to determine [19].…”

Section: Introductionmentioning

confidence: 99%

“…This analgesia was considered to be nonopioid-mediated and was reversible by NMDA antagonists [27]. Other studies with forced swim tests in mice [15,18] and rats [12], though, have found that the analgesia was reversed by naloxone. This difference is probably attributable to length of exercise, water temperature, and whether the swimming was intermittent or continuous [13,17,28].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running

Guo

Rhodes

Girard

et al. 2004

Physiology & Behavior

View full text Add to dashboard Cite

“…In animal studies, reduced pain sensitivity (most commonly the tail flickering test in rats) has been associated with increased levels of oxytocin, endorphins and/or enkephalins [24, 25, 26, 27, 28]. In a study of healthy humans, however, massage had no effects on serum levels of β-endorphins [29].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Clinical Trial of the Treatment Effects of Massage Compared to Relaxation Tape Recordings on Diffuse Long-Term Pain

Hasson

Arnetz

Jelveus

et al. 2003

Psychother Psychosom

View full text Add to dashboard Cite

Background: Long-term musculoskeletal pain is a common problem in primary health care settings that is difficult to treat. Two common treatments are mental relaxation and massage. Scientific studies show contradictory results. Furthermore, many studies lack long-term follow-up even though it is a chronic disorder. The purpose of this randomized clinical trial was to assess possible effects of massage as compared to listening to relaxation tapes in conditions of ‘diffuse’ and long-term musculoskeletal pain. Methods: 129 patients from primary health care suffering from long-term musculoskeletal pain were randomized to either a massage or mental relaxation group, and assessed before, during and after treatment. Results: During treatment there was a significant improvement in the three main outcome measures: self-rated health, mental energy, and muscle pain only in the massage group as compared to the relaxation group. However, at the 3-month post-treatment follow-up, there was a significant worsening in the outcome measures (time × group effect p < 0.05) back to initial rating levels in the massage group as compared to no changes in the relaxation group. Conclusion: Massage, but not mental relaxation, is beneficial in attenuating diffuse musculoskeletal symptoms. Beneficial effects were registered only during treatment. This lack of long-term benefits could be due to the short treatment period or treatments such as these do not address the underlying causes of pain. Future studies of long-term pain should include longer treatment periods and post-treatment follow-up. It might also be worthwhile assessing the long-term benefits from booster treatment after the initial intense treatment period.

show abstract

Swim stress reduces chronic pain in mice through an opioid mechanism

Cited by 38 publications

References 17 publications

Association of liking and reinforcing value with children's physical activity

Association of liking and reinforcing value with children's physical activity

Opioid-mediated pain sensitivity in mice bred for high voluntary wheel running

A Randomized Clinical Trial of the Treatment Effects of Massage Compared to Relaxation Tape Recordings on Diffuse Long-Term Pain

Contact Info

Product

Resources

About