SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

Nucleosome Remodeling and Epigenetics

“…Remodeling factors may have other, less explored functions as well. We know of isolated examples in which remodelers use their ATP-dependent DNA translocase activities to modulate the chromatin association of nonhistone substrates (Kia et al 2008;Wollmann et al 2011). We also contemplate their impact on chromatin organization independent of their enzymatic remodeling reactions, given the large number of remodeling machines associated with chromatin (Varga-Weisz and Becker 2006).…”

Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16 INK4A and p14 ARF expression

“…Immunoprecipitated DNAs were quantified by real-time qPCR using a SYBR Premix Ex Taq II kit (Takara) and a LightCycler (Roche) and were normalized to input DNA. Primers are listed in Table S1 (69).…”

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

“…However, it is clear that all aspects of p16 Ink4a regulation cannot be explained by factors described in this study and that the p16 Ink4a gene is subject to multiple levels of control (Jacobs et al, 1999;Passegué and Wagner, 2000;Ohtani et al, 2001Ohtani et al, , 2003Gonzalez et al, 2006;Bracken et al, 2007;Kotake et al, 2007;Baker et al, 2008;Kia et al, 2008;Agger et al, 2009;Barradas et al, 2009;Tzatsos et al, 2009;Witcher and Emerson, 2009 …”