Swertipunicoside. The first bisxanthone C-glycoside

Tan, Pei Jean; Hou, Cui-Ying; Liu, Yong-Long; Lin, Lee Juian; Cordell, Geoffrey A.

doi:10.1021/jo00025a032

Cited by 25 publications

(17 citation statements)

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“…Furthermore, some ions due to the loss of CO, CO 2 and H 2 O were found in the MS 3 spectra. The fragmentation pathway of swertianolin(5) was similar to that of norswertianolin(3). The [M-H-glc]ion at m/z 435 was detected as the base peak in the MS 2 spectra, and a fragment ion due to the loss of 15 Da (CH 3 ) appeared in the MS 3 spectra.…”

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confidence: 77%

“…All of the 17 xanthone reference compounds were previously isolated from the MeOH extract of Swertia punicea, [5] including puniceasides A-E (6, 10, 29, 30, and 33), mangiferin (1), [14] campestroside (2), [15] norswertianolin (3), [16] swertianolin (5), [16] 3-O-demethylswertipunicoside (8), [3] swertiabisxanthone I 8-O-b-D-glucopyranoside (9), [17] swertipunicoside (12), [3] norbellidifodin (15), [16] swerchirin (16), [14] swertiabisxantone I (17), [18] gentisin (19), [18] and bellidifodin (20) [16] (Fig. 1).…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

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Identification of xanthones from Swertia punicea using high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Wang

Zhang

et al. 2012

Rapid Comm Mass Spectrometry

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confidence: 77%

Section: Chemicals and Reagentsmentioning

confidence: 99%

Identification of xanthones from Swertia punicea using high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Wang

Zhang

et al. 2012

Rapid Comm Mass Spectrometry

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“…Mangiferin was also reported, as well as swertipunicoside, a C-glycoside bisxanthone consisting of a bellidifolin moiety linked to a mangiferin by a carbon-carbon linkage, previously identified in Swertia punicea (Tan et al 1991). In contrast with Gentianopsis and Comastoma, penta-substituted xanthones were reported, including some 1, 3,4,5,8-and 1,3,4,7,8-O-xanthones (Jia et al 2010a, b;Li et al 2011).…”

Section: Distribution Of Secondary Metabolites and Their Chemotaxonommentioning

confidence: 97%

Profiling, Isolation, Chemical Characterisation and Distribution of Gentianaceae Constituents

Wolfender

Urbain

Hostettmann

2015

The Gentianaceae - Volume 2: Biotechnology and Applications

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The family Gentianaceae includes about 1700 species over 90 genera. These plants are known to biosynthesise, in particular, rare polyphenolic pigments known as xanthones. They also produce flavonoids, as well as monoterpene glycosides (secoiridoids) which are their bitter principles. Numerous phytochemical studies have involved these constituents due to their pharmacological and chemotaxonomic relevance. The strategies used for the isolation of the different constit-

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“…Xanthones derivatives, flavonoids, irridoid glycosides, triterpenoids and dimeric xanthones have been isolated from the genus Swertia. 2,3 The genus are well known bitter tonic used against loss of appetite and fewer their bitter taste can be attributed to their content of xanthones and irridoids. 4 The most potential specie Swertia genus (S. chirata) is now nearly extinct from India.…”

Section: Introductionmentioning

confidence: 99%

HPTLC Analysis and Antiproliferative Effect of Various Extracts of Swertia alata on Growth of Leishmania donovani Promastigotes in vitro

Bajaj¹,

Wakode²,

Khan³

2017

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The present study was carried out to evaluate the quality control analysis and antiproliferative effects of petroleum ether, chloroform, ethanol and aqueous extracts of Swertia alata (family Gentianaceae) on Leishmania donovani. A basic, exact, quick and reproducible high performance thin layer chromatography (HPTLC) has been created for synchronous analysis of Oleanolic acid and Swertiamarin from S. alata. The method was validated for linearity, precision, specificity, accuracy and robustness. Densitometric scanning of the plates directly at 254nm was used for analysis of Swertiamarin, while as for the analysis of Oleanolic acid; plates were scanned for 520 nm after spraying with anis aldehyde-sulphuric acid reagent. For the extract of plants and Amphotericin B, the concentration response curve was plotted and IC 50 values were determined and also MTT assay was carried out for comparative study. Compact bands of Oleanolic acid and Swertiamarin were obtained at R f 0.62±0.001 and 0.66±0.002, linearity was satisfactory for oleanolic acid and swertiamarin. The developed and validated HPTLC methods were having Linearity range 200-2000 and 100-2000 ng/spot for oleanolic acid and swertiamarin respectively with r 2 value 0.989±0.003 and 0.999±0.03, limit of detection (11.25 and 6.19 ng/spot), limit of quantification (37.51 and 20.64 ng/spot), recovery (98.4-101.0 % and 98.2-100.8%) and precision with % RSD < 2%. Various dried extracts were found to contain oleanolic acid in the range of 0.009%-0.012% and swertiamarin in the range of 0.113-0.135% (w/w). Cytotoxicity assay of extracts over promastigotes showed that ethanolic extract was found to be most cytotoxic (IC 50 31.43±1.90 g/mL) after 96 h in comparison to other extracts. The ethanolic extract showed significant reduction in promastigotes which may be due to presence of oleanolic acid as compared with the other groups. The present HPTLC method is being reported for the first time and can be used for routine quality control. Key words: Antiproliferative, HPTLC, Oleanolic acid, Quality control, Swertiamarin. 14 Oleanolic acid and swertiamarin are very important bioactive constituents of S. alata; therefore, there is an urgent need to develop a simple method for estimation of two chemotherapeutic compound using sophisticated instruments like high performance liquid chromatography (HPTLC). Till date, several analytical methods have been reported for analysis of these both the compounds. However, literature survey shows no single quantitative method available for estimation of both the compounds in the plant S. alata. Sakshi Bajaj et al.: HPTLC analysis and antiproliferative effect of various extracts of Swertia alata S108Pharmacognosy Journal, Vol 9, Issue 6 (Suppl), Nov-Dec, 2017 well closed containers under refrigeration until used for the biological testing. Preparation of standard and quality control (QC) samplesStock solutions of Oleanolic acid and Swertiamarin (10mg/mL) were prepared in HPLC grade methanol and by appropriate dilution standard soluti...

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Swertipunicoside. The first bisxanthone C-glycoside

Cited by 25 publications

References 0 publications

Identification of xanthones from Swertia punicea using high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Identification of xanthones from Swertia punicea using high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

Profiling, Isolation, Chemical Characterisation and Distribution of Gentianaceae Constituents

HPTLC Analysis and Antiproliferative Effect of Various Extracts of Swertia alata on Growth of Leishmania donovani Promastigotes in vitro

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