Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes

Abstract

BackgroundTo report the thickness of the retina, retinal ganglion cell (RGC)-related layers, and choroid in healthy subjects using swept source optical coherence tomography (SS-OCT).MethodsOne hundred and forty-six healthy volunteers were consecutively recruited for this prospective observational study. Thickness of retina, RGC-related layers, and choroid in the standard early treatment of diabetic retinopathy study (ETDRS) grid were automatically measured using one SS-OCT (DRI OCT-1, Topcon, Japan). The IOL Master (Carl Zeiss Meditec, Germany) was used to measure axial length (AL).ResultsThicknesses of the average macular ganglion cell complex (GCC) and ganglion cell-inner plexiform layer (GCIPL) were 105.3 ± 9.7 and 78.5 ± 6.2 um respectively. Neither of them was significantly related with sex, age, or AL. Both showed strong correlations with retinal thickness (r = 0.793, p = 0.000; r = 0.813, p = 0.000, respectively) and with similar topographic distributions within the retina. The thicknesses of retina and GCC/GCIPL in the inner sectors were significantly higher than in the outer sectors of the EDTRS area, while in the same region of the macula, the choroid exhibited completely different patterns of topographic variation. Men had 7.8 um thicker retina and 34.9 um thicker choroid than women after adjustment for age and AL (all p < 0.05). Age and AL could significantly influence the choroidal thickness but not the retina (all p < 0.05).ConclusionThickness of GCC/GCIPL in healthy Chinese individuals is not dramatically different across gender, age, and AL groups in terms of ETDRS grid, but sex is critical for retinal and choroidal thickness. Choroidal structure (but not retinal) can be significantly influenced by age and AL.Electronic supplementary materialThe online version of this article (doi:10.1186/s12886-015-0110-3) contains supplementary material, which is available to authorized users.

Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography

“…Other parameters that did not meet this statistical criterion but with known clinical relevance for choroidal vasculature (such as spherical equivalent) were also considered. [32][33][34][35] A backward (step-down) elimination procedure was then used to achieve the multivariate models presented.…”

Normative values of the retinal macular thickness in a middle eastern population

“…Based on this understanding, the aforementioned changes can be detected early by imaging the macula using an Ocular Coherence Tomography that facilitates both thicknesses and morphology detection before these changes are clinically apparent. In effect, early detection may favorably affect the visual outcome [7]. In the clinic, Fourier-domain OCT is used in standard commercial systems and offers superior sensitivity compared to the conventional time-domain approach [7,8].…”

“…In effect, early detection may favorably affect the visual outcome [7]. In the clinic, Fourier-domain OCT is used in standard commercial systems and offers superior sensitivity compared to the conventional time-domain approach [7,8].…”

Analysis of Choroidal Thickness Change after 25-Gauge Vitrectomy for Idiopathic Epiretinal Membrane with or without Phacoemulsification and Intraocular Lens Implantation

“…More recently, using different light sources with longer wavelengths (1,060 nm vs. 800 nm), swept-source OCT provides an alternative to the EDI spectral-domain acquisition system [3] .…”